Stromal Progenitor Cells in Mitigation of Non-Hematopoietic Radiation Injuries [0.03%]
基质干细胞在非造血辐射损伤治疗中的作用
Shilpa Kulkarni,Timothy C Wang,Chandan Guha
Shilpa Kulkarni
Purpose of review: Therapeutic exposure to high doses of radiation can severely impair organ function due to ablation of stem cells. Normal tissue injury is a dose-limiting toxicity for radiation therapy (RT). Although ad...
Aditi Dubey,Jean-Pierre Saint-Jeannet
Aditi Dubey
Purpose of review: Craniofacial disorders are among the most common human birth defects and present an enormous health care and social burden. The development of animal models has been instrumental to investigate fundamen...
Retinal Degeneration and Regeneration-Lessons From Fishes and Amphibians [0.03%]
视网膜的退行与再生——来自鱼类和两栖类动物的研究启示
Divya Ail,Muriel Perron
Divya Ail
Purpose of review: Retinal degenerative diseases have immense socio-economic impact. Studying animal models that recapitulate human eye pathologies aids in understanding the pathogenesis of diseases and allows for the dis...
Fluid mechanics as a driver of tissue-scale mechanical signaling in organogenesis [0.03%]
流体动力学在器官发生过程中作为组织尺度机械信号传导的驱动力
Rachel M Gilbert,Joshua T Morgan,Elizabeth S Marcin et al.
Rachel M Gilbert et al.
Purpose of review: Organogenesis is the process during development by which cells self-assemble into complex, multi-scale tissues. Whereas significant focus and research effort has demonstrated the importance of solid mec...
Long-Term Culture of Intestinal Cell Progenitors: An Overview of Their Development, Application, and Associated Technologies [0.03%]
肠细胞祖体的长期培养：其发展、应用及相关技术综述
Andrew J Hollins,Lee Parry
Andrew J Hollins
Purpose of review: Long-term culture of adult progenitor cells in 3D is a recently emerging technology that inhabits the space between 2D cell lines and organ slice culture. ...
Nikolaos Panagiotou,R Wayne Davies,Colin Selman et al.
Nikolaos Panagiotou et al.
Purpose of review: Microvesicles (MVs) have been recognised as mediators of stem cell function, enabling and guiding their regenerative effects. Recent fi...
Ellaine Salvador,Malgorzata Burek,Carola Y Förster
Ellaine Salvador
Purpose of review: Tight junctions (TJs) are specialized differentiations of epithelial and endothelial cell membranes. TJs play an important role in the adhesion of cells and their interaction with each other. Most cance...
The mechanisms of HSC activation and epigenetic regulation of HSCs phenotypes [0.03%]
造血干细胞激活及表观遗传调控机制研究
Agata Page,Derek A Mann,Jelena Mann
Agata Page
Epigenetics is a dynamically expanding field of science entailing numerous regulatory mechanisms controlling changes of gene expression in response to environmental factors. Over the recent years there has been a great interest in epigeneti...
How to Grow a Lung: Applying Principles of Developmental Biology to Generate Lung Lineages from Human Pluripotent Stem Cells [0.03%]
用发育生物学原理指导多能干细胞分化成为肺细胞系
Briana R Dye,Alyssa J Miller,Jason R Spence
Briana R Dye
The number and severity of diseases affecting human lung development and adult respiratory function has stimulated great interest in new in vitro models to study the human lung. This review summarizes the most recent breakthroughs deriving ...
The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease [0.03%]
IL-17信号在酒精性肝病肝脑轴及肠黏膜屏障调节中的作用研究
Hsiao-Yen Ma,Jun Xu,Xiao Liu et al.
Hsiao-Yen Ma et al.
Alcoholic liver disease (ALD) progresses from a normal liver, to steatosis, steatohepatitis, fibrosis and hepatocellular carcinoma (HCC). Despite intensive studies, the pathogenesis of ALD is poorly understood, in part due to a lack of suit...