Arti V Shinde,Nikolaos G Frangogiannis
Arti V Shinde
Purpose of review: Activated fibroblasts are critically implicated in repair and remodeling of the injured heart. This manuscript discusses recent progress in the cell biology of fibroblasts in the infarcted and remodelin...
The Contractile Phenotype of Dermal Fetal Fibroblasts in Scarless Wound Healing [0.03%]
胎儿真皮纤维母细胞在无瘢痕伤口愈合中的收缩表型
Aron Parekh,Patricia A Hebda
Aron Parekh
Purpose of review: Injured skin in the mammalian fetus can heal regeneratively due to the ability of fetal fibroblasts to effectively reorganize the extracellular matrix (ECM). This process occurs without fetal fibroblast...
Rui Kang,Daolin Tang
Rui Kang
Purpose of review: Autophagy is a conserved intracellular degradation system and plays a dual role in cell death, depending on context and phase. Ferroptosis is a new form of regulated cell death that mainly depends on ir...
Towards Organs on Demand: Breakthroughs and Challenges in Models of Organogenesis [0.03%]
迈向按需器官的时代：器官发生模型的突破与挑战
Maria Giovanna Francipane,Eric Lagasse
Maria Giovanna Francipane
In recent years, functional three-dimensional (3D) tissue generation in vitro has been significantly advanced by tissue-engineering methods, achieving better reproduction of complex native organs compared to conventional culture systems. Th...
MicroRNAs in Cancer: challenges and opportunities in early detection, disease monitoring, and therapeutic agents [0.03%]
微小核糖核酸与癌症：在早期检测、疾病监测和药物治疗方面的挑战及机遇
Namita Chatterjee,Shushan Rana,Cristina Espinosa-Diez et al.
Namita Chatterjee et al.
Purpose of review: The goals of this review are to examine the usefulness of miRNAs as diagnostic and prognostic biomarkers for cancer and to evaluate the applicability of miRNAs as cancer therapeutics. ...
Tumor immunology viewed from alternative animal models-the Xenopus story [0.03%]
从非传统动物模型视角看肿瘤免疫学-非洲爪蟾的故事
Maureen Banach,Jacques Robert
Maureen Banach
A purpose of review: Nonmammalian comparative animal models are important not only to gain fundamental evolutionary understanding of the complex interactions of tumors with the immune system, but also to better predict th...
The Influence of Extracellular RNA on Cell Behavior in Health, Disease and Regeneration [0.03%]
细胞外RNA对健康、疾病和再生中细胞行为的影响
Luai Huleihel,Michelle E Scarritt,Stephen F Badylak
Luai Huleihel
Purpose of review: An overview of the role of extracellular RNAs (exRNA) in the regulation of homeostasis, disease progression, and regeneration is provided herein. Several exRNAs have been identified as potential biomark...
Maria Cecilia Cirio,Mark P de Caestecker,Neil A Hukriede
Maria Cecilia Cirio
The vertebrate kidney possesses the capacity to repair damaged nephrons, and this potential is conserved regardless of the complexity of species-specific kidneys. However, many aquatic vertebrates possess the ability to not only repair exis...
Andrew J Warburton,David N Boone
Andrew J Warburton
Purpose of review: The goal of this review was to compare and contrast the results and implications from several recent transcriptomic studies that analyzed the expression of lncRNAs in breast cancer. How many lncRNAs are...
Marko Z Nikolić,Emma L Rawlins
Marko Z Nikolić
Purpose of review: The lung research field has pioneered the use of organoids for the study of cell-cell interactions. Recent findings: ...