Liver Disease in Alpha-1 Antitrypsin Deficiency: Current Approaches and Future Directions [0.03%]
α1抗胰蛋白酶缺乏症肝病的当前研究方法及未来发展方向
Ellen L Mitchell,Zahida Khan
Ellen L Mitchell
Purpose of review: The aim of the study is to review the liver disease caused by alpha-1 antitrypsin deficiency (A1ATD), including pathogenesis, epidemiology, diagnostic testing, and recent therapeutic developments. ...
The Regulation of Notch Signaling in Retinal Development and Regeneration [0.03%]
notch信号在视网膜发育和再生中的调控作用
Elizabeth A Mills,Daniel Goldman
Elizabeth A Mills
Purpose of review: Notch signaling is an important component of retinal progenitor cell maintenance and MG specification during development, and its manipulation may be critical for allowing MG to re-enter the cell cycle ...
Melissa A Gilbert,Nancy B Spinner
Melissa A Gilbert
Purpose of review: We review the genetics of the autosomal dominant, multi-system disorder, Alagille syndrome and provide a summary on how current functional models and emerging biotechnologies are equipped to guide scien...
Adipose Tissue Metabolism and Cancer Progression: Novel Insights from Gut Microbiota? [0.03%]
肠道菌群对脂肪组织代谢和癌症进展的新型调控作用？
Benedicte F Jordan,Florian Gourgue,Patrice D Cani
Benedicte F Jordan
Purpose of review: Obesity is strongly associated with the development of several types of cancers. This review aims to discuss the recent key mechanisms and actors underlying the link between adipose tissue metabolism an...
Duc-Hung Pham,Changwen Zhang,Chunyue Yin
Duc-Hung Pham
Purpose of review: The liver is the largest internal organ and performs both exocrine and endocrine function that is necessary for survival. Liver failure is among the leading causes of death and represents a major global...
An interspecies heart-to-heart: Using Xenopus to uncover the genetic basis of congenital heart disease [0.03%]
跨越物种的心跳同频——利用非洲爪蟾揭示先天性心脏病的遗传机制
Alexandra MacColl Garfinkel,Mustafa K Khokha
Alexandra MacColl Garfinkel
Purpose of review: Given the enormous impact congenital heart disease has on child health, it is imperative that we improve our understanding of the disease mechanisms that underlie patient phenotypes and clinical outcome...
Non-canonical activation of NRF2: New insights and its relevance to disease [0.03%]
非 canonical 的 NRF2 激活作用：新见解及其与疾病的相关性
Matthew Dodson,Donna D Zhang
Matthew Dodson
Purpose of review: The goal of this review is to summarize the current knowledge in the field regarding the non-canonical activation of the NRF2 pathway. Specifically, we address what role p62 plays in mediating this path...
Roberta A Gottlieb,Amandine Thomas
Roberta A Gottlieb
Purpose of review: Mitochondrial homeostasis and quality control are essential to maintenance of cardiac function and a disruption of this pathway can lead to deleterious cardiac consequences. ...
Heterogeneity of Fibroblasts and Myofibroblasts in Pulmonary Fibrosis [0.03%]
特发性肺纤维化中成纤维细胞和肌成纤维细胞的异质性分析
David M Habiel,Cory M Hogaboam
David M Habiel
Purpose of review: Idiopathic Pulmonary Fibrosis (IPF) is the most common form of interstitial lung diseases of unknown eathiopathogenesis, mean survival of 3-5 years and limited therapeutics. Characterized by a loss of a...
Altea Rocchi,Congcong He
Altea Rocchi
Purpose of review: Physical exercise is a highly effective method to prevent several pathogenic conditions, such as obesity, type 2 diabetes and cardiovascular diseases, largely due to metabolic adaptations induced by exe...