Evolutionary Stem Cell Poker and Cancer Risks: The Paradox of The Large And Small Intestines [0.03%]
进化干细胞扑克与癌症风险：大肠和小肠的悖论
Darryl Shibata
Darryl Shibata
Purpose of review: Recent studies demonstrate that normal human tissues accumulate substantial numbers of somatic mutations with aging, to levels comparable to their corresponding cancers. If mutations cause cancer, how d...
Effects of Partial Gravity on the Function and Particle Handling of the Human Lung [0.03%]
部分重力对人体肺功能和颗粒处理的影响
G Kim Prisk
G Kim Prisk
Purpose of review: The challenges presented to the lung by the space environment are the effects of prolonged absence of gravity, the challenges of decompression stress associated with spacewalking, and the changes in the...
Liquid Biopsy Preservation Solutions for Standardized Pre-Analytical Workflows-Venous Whole Blood and Plasma [0.03%]
用于标准化前分析工作流程的液体活检保存溶液-静脉全血和血浆
Daniel Grölz,Siegfried Hauch,Martin Schlumpberger et al.
Daniel Grölz et al.
Purpose of review: Liquid biopsy analyses based on circulating cell-free nucleic acids, circulating tumor cells or other diseased cells from organs, and exosomes or other microvesicles in blood offer new means for non-inv...
Tumor Pre-Analytics in Molecular Pathology: Impact on Protein Expression and Analysis [0.03%]
分子病理学中的肿瘤前期分析：对蛋白质表达和分析的影响
Veronique M Neumeister,Hartmut Juhl
Veronique M Neumeister
Purpose of review: Precision medicine promises patient tailored, individualized diagnosis and treatment of diseases and relies on clinical specimen integrity and accuracy of companion diagnostic testing. Therefore, pre-an...
Nancy Y Villa,Grant McFadden
Nancy Y Villa
Purpose of review: This review discusses the pathophysiology, risk factors, and the advances in the prevention or treatment of graft-vs-host disease (GvHD) by exploiting adjunct virotherapy. In addition, nonviral adjunct ...
Amy M Boddy,Weini Huang,Athena Aktipis
Amy M Boddy
Purpose: In this paper, we provide an overview of a life history theory and how it applies to cancer evolution. Recent findings: We rev...
Microbial interactions with the intestinal epithelium and beyond: Focusing on immune cell maturation and homeostasis [0.03%]
肠道上皮内外的微生物相互作用：重点关注免疫细胞的发育和稳态
Bhanu Priya Ganesh,Robert Fultz,Sriram Ayyaswamy et al.
Bhanu Priya Ganesh et al.
Microbial metabolites influence the function of epithelial, endothelial and immune cells in the intestinal mucosa. Microbial metabolites like SCFAs and B complex vitamins direct macrophage polarization whereas microbial derived biogenic ami...
Melanie Rodrigues,Geoffrey Gurtner
Melanie Rodrigues
Purpose of review: Macrophages alter their responses during the temporal stages of wound healing. During the inflammatory phase macrophages perform phagocytosis. During neovascularization macrophages activate angiogenesis...
The Pro-reparative Engine: Stem Cells Aid Healing by Dampening Inflammation [0.03%]
向修复倾斜：干细胞通过抑制炎症促进修复
Andrew Bradshaw,Kyle Sylakowski,Alan Wells
Andrew Bradshaw
Purpose of review: Stem cells have been proposed as sources for tissue replacement when healing does not occur. These cells could contribute directly to skin structures via differentiation, or via producing trophic factor...
Thu Elizabeth Duong,James S Hagood
Thu Elizabeth Duong
Purpose of review: Myofibroblasts are the fundamental drivers of fibrosing disorders; there is great value in better defining epigenetic networks involved in myofibroblast behavior. Complex epigenetic paradigms, which are...