Hitting Them Where They Live: Targeting the Glioblastoma Perivascular Stem Cell Niche [0.03%]
精准打击胶质母细胞瘤血管周干细胞生态位
Michael D Brooks,Rajarshi Sengupta,Steven C Snyder et al.
Michael D Brooks et al.
Glioblastoma growth potential and resistance to therapy is currently largely attributed to a subset of tumor cells with stem-like properties. If correct, this means that cure will not be possible without eradication of the stem cell fractio...
Antonia R Sepulveda
Antonia R Sepulveda
Helicobacter pylori infection leads to long-lasting chronic inflammation and represents the most common risk factor underlying gastric cancer. Recently, new insights into the mechanisms through which H. pylori and mucosal inflammation lead ...
Amy P Wong,Janet Rossant
Amy P Wong
The understanding of key processes and signaling mechanisms in lung development has been mainly demonstrated through gain and loss of function studies in mice, while human lung development remains largely unexplored due to inaccessibility. ...
Shu-Hao Hsu,Kalpana Ghoshal
Shu-Hao Hsu
MicroRNAs (miRNAs), a class of short non-coding RNAs, have been studied intensely and extensively in the past decade in every aspect of biological processes, including cell differentiation, proliferation and death. These findings pointed ou...
Inflammation and Gliomagenesis: Bi-Directional Communication at Early and Late Stages of Tumor Progression [0.03%]
炎症与脑胶质瘤发生：肿瘤进展早期和晚期的双向通讯
Rui Pedro Galvão,Hui Zong
Rui Pedro Galvão
Inflammation has been closely linked to various forms of cancer. Less is known about the role of inflammation in glioma, especially at the initiation stage. In this review, we first describe the unique features of the immune system in the b...
Paloma Del C Monroig,George A Calin
Paloma Del C Monroig
MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression that control cellular and developmental processes by targeting messenger RNAs (mRNA). These small non-coding RNAs (ncRNAs) are aberrantly expressed ...
Sonya Parpart,Xin Wei Wang
Sonya Parpart
MicroRNA (miRNA) function has been studied extensively in the last two decades. These short, non-coding RNAs influence a variety of cellular processes through repression of target genes. With the number of genes that a single miRNA can targ...
Xichun Wang,Xianghui Fu,Carl Van Ness et al.
Xichun Wang et al.
Liver cancer, particularly hepatocellular carcinoma (HCC), is the third leading cause of cancer death in the world. Bile acids (BAs) are liver-produced amphipathic molecules that are required to facilitate the absorption of cholesterol, fat...
Eric D Mortenson,Yang-Xin Fu
Eric D Mortenson
Oncogenic signaling, such as HER2/neu signaling, has been shown to play major role for tumorigenesis in a subset of breast cancer patients. The use of anti-HER2/neu antibody has not only revealed the mechanisms for HER2/neu signaling but al...