Implications of Mesenchymal Cells in Cancer Stem Cell Populations: Relevance to EMT [0.03%]
间充质细胞在癌症干细胞群体中的作用及其对上皮间质转化的意义
Amy N Abell,Gary L Johnson
Amy N Abell
The epithelial to mesenchymal transition (EMT) generates tumor cells having stem cell characteristics with phenotypes similar to cancer stem cells (CSCs). Evidence suggests CSCs are in an intermediate state of EMT expressing reduced levels ...
Harmeet Malhi
Harmeet Malhi
MicroRNAs are small noncoding RNAs which regulate protein expression post-transcriptionally. They respond to changes in a cells environment and can promote cell death or cell survival depending on the context. Recent studies have linked mic...
Anjali Shroff,Andrew Mamalis,Jared Jagdeo
Anjali Shroff
Fibrosis is defined as increased fibroblast proliferation and deposition of extracellular matrix components with potential clinical ramifications including organ dysfunction and failure. Fibrosis is a characteristic finding of various skin ...
Strategies to Detect Hepatic Myofibroblasts in Liver Cirrhosis of Different Etiologies [0.03%]
不同病因肝硬化肝肌成纤维细胞的检测策略
Keiko Iwaisako,Kojiro Taura,Yukinori Koyama et al.
Keiko Iwaisako et al.
Liver cirrhosis, a late stage of hepatic fibrosis, is an increasing cause of morbidity and mortality worldwide. Hepatic fibrosis is mainly caused by alcoholic or non-alcoholic steatohepatitis, chronic viral hepatitis, or autoimmune and bili...
Noninvasive Biomarkers of Liver Fibrosis: Clinical Applications and Future Directions [0.03%]
非侵入性肝纤维化生物标志物的临床应用及未来发展方向
Daniel L Motola,Peter Caravan,Raymond T Chung et al.
Daniel L Motola et al.
Chronic liver disease is a significant cause of morbidity and mortality worldwide. Current strategies for assessing prognosis and treatment rely on accurate assessment of disease stage. Liver biopsy is the gold standard for assessing fibros...
Mouse models of liver fibrosis mimic human liver fibrosis of different etiologies [0.03%]
模拟不同病因肝纤维化的肝纤维化小鼠模型
Allyson K Martínez,Luca Maroni,Marco Marzioni et al.
Allyson K Martínez et al.
The liver has the amazing capacity to repair itself after injury; however, the same processes that are involved in liver regeneration after acute injury can cause serious consequences during chronic liver injury. In an effort to repair dama...
Carmen García-Ruiz,Neil Kaplowitz,José C Fernandez-Checa
Carmen García-Ruiz
Alcohol-induced liver disease (ALD) is a major health concern of alcohol abuse and a leading cause of liver-related morbidity and mortality. The pathogenesis of ALD is multifactorial and still ill characterized. One of the hallmarks of ALD ...
Steven P O&#x;Hara,Sergio A Gradilone,Tetyana V Masyuk et al.
Steven P O&#x;Hara et al.
Cholangiocytes, the cells lining bile ducts, comprise a small fraction of the total cellular component of the liver, yet perform the essential role of bile modification and transport of biliary and blood constituents. Cholangiopathies are a...
Beclin 1, an Essential Component and Master Regulator of PI3K-III in Health and Disease [0.03%]
Beclin 1——PI3KC3复合体的重要组成成分及其在健康和疾病中的调控作用
Nicole C McKnight,Yue Zhenyu
Nicole C McKnight
Autophagy is a cell 'self-digestion' pathway involving the synthesis, trafficking and delivery of autophagosomes to lysosomes for degradation. Beclin 1 is a core component of the class III phosphatidylinositol 3-kinase (PI3K-III) complex, w...
Dynamic Interactions Between Cancer Stem Cells And Their Stromal Partners [0.03%]
癌干细胞及其间质细胞伙伴之间的动态相互作用
Tea Soon Park,Vera S Donnenberg,Albert D Donnenberg et al.
Tea Soon Park et al.
The cancer stem cell (CSC) paradigm presumes the existence of self-renewing cancer cells capable of regenerating all tumor compartments and exhibiting stem cell-associated phenotypes. Recent interpretations of the CSC hypothesis envision st...