Chloramphenicol and tetracycline synergize with bacteriophage SeKF_13 to inactivate antimicrobial-resistant Salmonella Typhimurium [0.03%]
氯霉素和四环素与SeKF_13噬菌体协同作用灭活抗微生物药物的大肠杆菌中毒性弗氏志贺菌
Karen Fong,Thomas Guy,Ayesha Lone et al.
Karen Fong et al.
Non-typhoidal Salmonella is estimated to cause up to 1 billion cases of global foodborne illness per year. Salmonella Typhimurium is a serovar of gravest worldwide concern as it is capable of infecting animal and human hosts and can also ac...
Cell type-dependent induction of type I interferon and PARP1 activation in astrocytes and neurons during chikungunya virus infection [0.03%]
细胞类型依赖的诱导I型干扰素和PARP1在登革热病毒感染期间星形胶质细胞和神经元中的激活
Lisa Pieterse,Taewoo Kim,Che-Yuan Chang et al.
Lisa Pieterse et al.
Chikungunya virus, a mosquito-borne alphavirus, causes fever, rash, arthritis, and neurological disorders. Its non-structural protein 3 harbors a macrodomain, a key neurovirulence factor that removes adenosine diphosphate ribose from ADP-ri...
Arginine-substituted Mastoparan-C derivatives combat dual bacterial pathogens: in vitro mechanistic insights and in vivo efficacy in polymicrobial wounds [0.03%]
精氨修饰的Mastoparan-C衍生物对抗双重细菌病原体：体外机制研究和多微生物伤口治疗功效
Luyao Zhang,Anqi Huang,Mingyu Lu et al.
Luyao Zhang et al.
The synergistic interactions in multi-pathogen infections compromise wound healing and limit therapeutic efficacy. In this study, we designed and synthesized arginine-substituted derivatives of the antimicrobial peptide Mastoparan-C (MP-C)....
Fluoroquinolone-resistant Escherichia coli carrying quinolone efflux pump (qepA) with L348-G349 duplication in the absence of V134I substitution [0.03%]
不含V134I取代的携带喹诺酮类药物外排泵（qepA）的L348_G349重复的氟喹诺酮耐药的大肠埃希菌
Kevin Kariuki,Kirkby D Tickell,Collins Kigen et al.
Kevin Kariuki et al.
We report on five clinical fluoroquinolone-resistant Escherichia coli strains carrying a unique variant of the quinolone efflux pump gene (qepA). The E. coli isolates were recovered from fecal samples of children under 5 years collected at ...
Nitric oxide-releasing balloon inflation fluid for Foley catheters to prevent catheter-associated urinary tract infections [0.03%]
用于 Foley 导尿管的释放一氧化氮气囊扩张液可预防导管相关性泌尿系统感染
Ryan Kauffman,Katherine McCombs,Jianfeng Wu et al.
Ryan Kauffman et al.
Catheter-associated urinary tract infections (CAUTIs) are the most prevalent nosocomial infections. These infections impose a significant financial burden on the healthcare system and are responsible for approximately 15,000 deaths each yea...
Extended-spectrum beta-lactamases from French veal calves: WGS-based data will help build targeted AMR mitigation strategies [0.03%]
法国小牛肉犊牛的超广谱β-内酰胺酶：基于WGS的数据有助于构建针对性的抗微生物耐药性缓解策略
Marisa Haenni,Véronique Métayer,Antoine Drapeau et al.
Marisa Haenni et al.
Antimicrobial resistance (AMR) is an important One Health issue affecting the three human, animal, and environmental sectors. The occurrence of Escherichia coli resistant to extended-spectrum cephalosporins (ESC-R) is considered a relevant ...
Molecular and phenotypic characterization of Streptococcus uberis isolates from bovine mastitis milk in South Korea [0.03%]
韩国牛乳腺炎乳汁中无乳链球菌的分子及表型特征研究
Hye Jeong Kang,Ju-Yeon You,Seung Hoe Kim et al.
Hye Jeong Kang et al.
Streptococcus uberis, a major environmental pathogen, is frequently linked to recurrent or persistent intramammary infections, posing a challenge to mastitis control in dairy cattle. In this study, we characterized 112 S. uberis isolates re...
Phosphoethanolamine modification of lipid A found in five distinct Akkermansia species [0.03%]
五个不同的阿克曼菌物种中发现的脂质A的磷乙醇胺修饰形式
Silas Porter Crenna,Arianna Lagoudakis,Angela M Jackson et al.
Silas Porter Crenna et al.
Akkermansia is an important, diderm gut microbe associated with positive health outcomes. Recent advances in Akkermansia genomics have revealed great diversity in the genus, leading to the discovery of novel species and subspecies. Our know...
Diagnostic performance and interchangeability of two commercial anti-RSV-IgG and IgA ELISAs across clinically relevant populations [0.03%]
两种商业抗RSV-IgG和IgA ELISA的诊断性能及临床相关人群中的互换性评估
Rainer Gosert,Svenia Schmid,Laura Infanti et al.
Rainer Gosert et al.
Accurate assessment of anti-respiratory syncytial virus (RSV)-specific antibodies has gained importance following the introduction of RSV vaccines and long-acting monoclonal antibody prophylaxis. However, the analytical performance and inte...
A smear test aiding with an automated slide reader acquires equivalent sensitivity to MGIT960 culture in pulmonary tuberculosis diagnosis [0.03%]
用于自动化阅片仪的涂片检测在肺结核诊断中的敏感度可与MGIT 960培养法媲美
Chao Zhang,Haoran Wang,Yuqing Chen et al.
Chao Zhang et al.
Smear microscopy remains widely used for tuberculosis (TB) diagnosis due to its rapid turnaround and low cost, despite its relatively low sensitivity. With the advent of molecular tests, there is growing debate on whether the smear test rem...