The Deep Darkness microbiome: functional and taxonomic diversity in an oligotrophic temperate cave [0.03%]
深黑暗微生物群落：寡营养温和洞穴的功能和分类多样性
Philips O Akinwole,Nina G Shaffer,Emma E C Jacobs et al.
Philips O Akinwole et al.
Many subterranean ecosystems are chronically energy limited, yet the mechanisms governing microbial community assembly and metabolic function under extreme carbon scarcity remain poorly resolved. We combined 16S rRNA gene sequencing with co...
In vitro activity of aztreonam-avibactam and comparators against Enterobacterales isolated from bloodstream infections: ATLAS/ surveillance, 2021-2022 [0.03%]
2021-2022年ATLAS监测中分离的引起血流感染的肠杆菌目细菌对亚胺培南西司他丁、美罗培南和奥马扎imeravene_avibactam的体外活性
Gian Maria Rossolini,Fupin Hu,Nandini Sethuraman et al.
Gian Maria Rossolini et al.
Carbapenem-resistant Enterobacterales (CRE) present a major global health concern due to rapid spread, high mortality, and limited treatment options. Metallo-β-lactamase (MBL)-producing CRE, particularly those harboring New Delhi metallo-...
Evaluation of Legionella pneumophila confirmation methods following IDEXX Legiolert analysis of groundwater [0.03%]
IDEXX Legiolert分析地下水后确认Legionella pneumophila方法的评估
Christina M Morrison,Phillip Wang,Gabriela Portillo-Chamul et al.
Christina M Morrison et al.
The IDEXX Legiolert test has been implemented for the quantification of Legionella pneumophila in a variety of potable and non-potable water matrices. For example, through coordination with the state regulatory agency, the Southern Nevada W...
Detection of lymphocytic choriomeningitis virus (LCMV) in the common house mice (Mus musculus) in Italy: an underrecognized threat to human health [0.03%]
意大利小家鼠中淋巴细胞脉络丛脑膜炎病毒(LCMV)的检测：对人类健康的潜在威胁未引起足够重视
Barbara Di Martino,Federica Di Profio,Serena Robetto et al.
Barbara Di Martino et al.
Lymphocytic choriomeningitis virus (LCMV) is a neglected zoonotic pathogen primarily transmitted by the house mouse (Mus musculus). Despite being an underestimated zoonotic threat in Europe, LCMV lacks comprehensive surveillance. In this st...
Diagnostic accuracy and inter-lot precision of the FujiLAM II point-of-care assay to detect tuberculosis in stored urine specimens from people living with HIV [0.03%]
富士LAM II现场检测试剂诊断肺结核及批间一致性研究：用HIV感染者储存尿样进行检测
Nestor Biatu,Cyrille Mbuli,Comfort Vuchas et al.
Nestor Biatu et al.
The Fujifilm SILVAMP TB LAM II (FujiLAM II) assay is a lateral flow assay that detects TB from urine specimens. This updated version of the assay has been redesigned to address inter-lot variability issues of the original FujiLAM assay. We ...
Patterns of antimicrobial resistance genes in pathogens across One Health sectors in Ireland: an in silico approach [0.03%]
爱尔兰大健康管理各领域病原体中抗微生物药物耐药基因的分布特征（一种基于计算的方法）
Akhil Prakash,Eva Kilcoyne,Damien Tansey et al.
Akhil Prakash et al.
As part of a rapid risk assessment, an in silico approach was used to detect antimicrobial resistance (AMR) in pathogenic isolates from humans, animals, and the environment. A total of 11,670 genomic data sets were retrieved from the NCBI P...
PHGDH restricts porcine reproductive and respiratory syndrome virus replication by sustaining cellular antioxidant capacity and redox homeostasis [0.03%]
PHGDH通过维持细胞抗氧化能力和氧化还原稳态来限制猪生殖与呼吸综合症病毒的复制
Zhangping Yu,Qiongqiong Zhou,Peng Gao et al.
Zhangping Yu et al.
Porcine reproductive and respiratory syndrome virus (PRRSV) remains a major threat to the swine industry. Although redox imbalance and oxidative stress are known to favor PRRSV infection, the host determinants that preserve redox homeostasi...
Sinomenine protects mice against Staphylococcus aureus-induced endometritis through inhibition of P2X7 receptor-mediated ferroptosis and inflammation [0.03%]
延胡索碱通过抑制P2X7受体介导的铁死亡和炎症来保护小鼠免受金黄色葡萄球菌诱导的子宫内膜炎的影响
Yue Zhang,Sixuan Li,Qingsong Sun et al.
Yue Zhang et al.
Endometritis is a major cause of infertility that adversely impacts both human reproductive health and livestock productivity. This study investigated the protective effects and underlying mechanisms of sinomenine (SIN) against Staphylococc...
Metabolic adaptations in antibiotic-resistant Staphylococcus aureus: understanding resistance mechanisms and enhancing antibiotic efficacy [0.03%]
耐药表皮葡萄球菌中的代谢适应：理解耐药机制及提高抗生素疗效
Zhiyu Pan,Wan Zhang,Zhuo Ying Cao et al.
Zhiyu Pan et al.
The global rise of antibiotic-resistant Staphylococcus aureus represents a serious clinical challenge, contributing substantially to the burden of antimicrobial resistance. This study explores the metabolic mechanisms of antibiotic-resistan...
Validation of an integrated metagenomic pipeline combining optimized wet-lab processing and tiered reporting for CSF pathogen detection [0.03%]
结合优化的实验处理和分层报告的脑脊液病原体检测综合元基因组管道的验证
Alec Victorsen,Todd P Knutson,Lucas Bolender et al.
Alec Victorsen et al.
Metagenomic next-generation sequencing (mNGS) in the infectious disease diagnostic space has been gaining traction and is popular for aiding in the diagnosis of central nervous system infections. However, many challenges and obstacles remai...