Grass supplementation to a pellet-based diet fails to enrich gut microbiomes with wild-like functions in captive-bred hares [0.03%]
以颗粒饲料为基础的饲喂中添加牧草无法使人工圈养兔子肠道微生物群落获得类似野外的功能菌群
Ostaizka Aizpurua,Garazi Martin-Bideguren,Nanna Gaun et al.
Ostaizka Aizpurua et al.
Reintroducing captive-bred animals into the wild often faces limited success, with the underlying causes frequently unclear. One emerging hypothesis is that maladapted gut microbiota may play a significant role in these challenges. To inves...
One-step multiplex PCR assay for identification of Mycobacterium kansasii complex species [0.03%]
一种鉴定堪萨斯分枝杆菌复合群物种的一步多重PCR检测方法
Paulina Joanna Wałpuska,Zofia Bakuła,Katarzyna Rastawicka et al.
Paulina Joanna Wałpuska et al.
Currently, the Mycobacterium kansasii complex (MKC) species identification involves PCR amplification, followed by sequencing or digestion of the amplicons. The purpose of this study was to develop a one-step multiplex PCR assay allowing fo...
Evaluation of the Ultima Genomics UG 100 sequencer for low-cost, high-sensitivity metagenomic pathogen detection from cerebrospinal fluid [0.03%]
评估Ultima Genomics UG 100测序仪，该仪器可从脑脊液中进行低成本、高灵敏度的元基因组病原体检测
Ryan C Shean,Keith D Tardif,Alexandra Rangel et al.
Ryan C Shean et al.
Clinical metagenomic next-generation sequencing (mNGS) is a diagnostic tool allowing near-universal pathogen detection directly from clinical specimens. Despite promising clinical data, broad adoption of mNGS has been hindered by high cost ...
Functional analysis of purM in Burkholderia cenocepacia using a trimethoprim-selectable allelic exchange and mini-Tn7 complementation approach [0.03%]
绿脓分支杆菌BURKHOLDERIA CENOCEPACIA中PURM基因的功能分析及其反向遗传学研究
May Myat Noe,Kornvalee Meesilpavikkai,Yada Ajimathorn et al.
May Myat Noe et al.
Burkholderia cenocepacia, a member of the Burkholderia cepacia complex (Bcc) poses a significant threat to immunocompromised individuals, particularly those with cystic fibrosis. Progress in understanding its pathogenesis has been hindered ...
Pleiotropic roles of elongation factor P in Bacillus subtilis physiology revealed by phenotypic and multi-omics analyses [0.03%]
结合表型和组学分析揭示的延长因子P在芽孢杆菌生理中的多效性作用
Mitsuo Ogura,Yu Kanesaki
Mitsuo Ogura
Elongation factor P (EF-P) is conserved across the three kingdoms and alleviates ribosome stalling at the XPPX motif of a protein. A genome-wide ribosome-stalling atlas was previously created for the ancestral strain NCIB3610. However, repo...
Gut microbial community structure, metabolic signature, and resistome in dyslipidemia: implications for cardiovascular disease management [0.03%]
高脂血症肠道微生物组结构、代谢标志物和抗性基因组的特征及其对心血管疾病管理的影响
Soomin Lee,Hyung-Lae Kim,Shahbaz Raza et al.
Soomin Lee et al.
Dyslipidemia, characterized by abnormal blood lipid levels, constitutes a significant risk factor for cardiovascular disease. Emerging evidence indicates that the gut microbiota influences lipid metabolism, although findings across studies ...
Targeted sortase A inhibition by novel peptidomimetic antivirulents against staphylococcal infections [0.03%]
针对金黄色葡萄球菌感染的新型抗毒小分子sortase A特异性抑制剂
Jordi C J Hintzen,Shadi Rahimi,Daniel Tietze et al.
Jordi C J Hintzen et al.
Antibiotic resistance is a critical public health issue, causing resistant bacterial strains to be increasingly difficult to control. Antivirulence therapies, which target bacterial virulence factors rather than kill bacteria, present a pro...
Precision of a phage susceptibility spot assay assessed with 154 clinical Staphylococcus aureus isolates [0.03%]
噬菌斑药敏试验的精确度评估及其在154株临床分离表皮葡萄球菌中的应用
Sebastian C Herren,Christoph L Zink,Jay Mandrekar et al.
Sebastian C Herren et al.
Lytic phages are a promising consideration to combat recalcitrant bacterial infections. To advance the possibility of using phage therapy in the clinical routine, standardized phage susceptibility testing methods are needed. Here, staphyloc...
Limited contribution of compensatory mutations to MDR/RR-TB clustering in Hunan Province, China: a population-based whole-genome sequencing study [0.03%]
中国湖南省多药耐药/耐利福平结核病聚集的有限补偿突变作用：基于人群的全基因组测序研究
Wencong He,Yunhong Tan,Zexuan Song et al.
Wencong He et al.
Transmission of rifampicin-resistant and multidrug-resistant tuberculosis (MDR/RR-TB) is a major driver of the global drug-resistant TB epidemic, yet the contribution of compensatory mutations to its spread remains uncertain. We analyzed 20...
Dissecting the effect of single- and co-infection of TB and COVID-19 pathogens on the sputum microbiome [0.03%]
剖析单一及共同感染的肺结核和新冠肺炎病原体对痰微生物组的影响
Brintha Vijayakumar Padmavathy,Ashok Kumar Shanmugavel,Sivakumar Shanmugam et al.
Brintha Vijayakumar Padmavathy et al.
Tuberculosis (TB) and COVID-19 are both respiratory diseases, and understanding their interaction is important for effective co-infection management. Although some studies have investigated TB and COVID-19 co-infection in terms of immune re...