High-throughput screening system for antimycobacterial compounds using in vitro infected cells: construction and application to compounds in the Ōmura Natural Compound Library [0.03%]
一种用于抗分枝杆菌化合物的高通量筛选系统：利用体外感染细胞进行构建及其在大村天然产物库中的应用
Takemasa Takii,Aoi Kimishima,Masato Iwatsuki et al.
Takemasa Takii et al.
The global increase in multidrug-resistant tuberculosis strains poses a major threat; consequently, there is an urgent need to identify and develop novel drugs. We have previously presented a simple fibroblast assay (SFA) screening method t...
Lineage-associated differences in adenine methylation patterns of mammalian-associated Campylobacter fetus isolates: a possible role for epigenetic factors in host tropism and pathogenesis [0.03%]
与宿主亲嗜性和致病性相关的哺乳动物型Campylobacter fetus分离株的腺嘌呤甲基化模式差异：表观遗传因素的可能作用
Susan Nadin-Davis,Marc-Olivier Duceppe,Mingsong Kang et al.
Susan Nadin-Davis et al.
Mammalian Campylobacter fetus (CF) is divided into two subspecies, C. fetus fetus (CFF) and C. fetus venerealis (CFV), the latter being bovine-adapted and responsible for the notifiable disease bovine genital campylobacteriosis (BGC). Diffe...
Rapid delineation of Acinetobacter baumannii dose responses to zosurabalpin based on machine learning-assisted interpretation of bacterial nanomotions [0.03%]
基于机器学习辅助的细菌纳米运动解读的鲍曼不动杆菌剂量响应的快速界定
Marta Pla Verge,Jan Winnicki,Amanda Luraschi-Eggemann et al.
Marta Pla Verge et al.
Carbapenem-resistant Acinetobacter baumannii (CRAB) represents a major clinical threat, underscoring the urgent need for both new antibiotics and rapid antimicrobial susceptibility testing (AST) methods that can inform treatment. Here, we d...
Epidemiological and molecular characterization of multidrug-resistant Corynebacterium striatum in a tertiary hospital in China [0.03%]
中国一家三级医院多重耐药类星型奴卡放线菌的流行病学和分子特征分析
Xia Li,Hong Li,Chunyan Gao et al.
Xia Li et al.
Corynebacterium striatum has emerged as an important opportunistic nosocomial infection; however, epidemiological and antimicrobial resistance data from China remain limited. This study explored the epidemiological distribution, antimicrobi...
Single-cell analysis of HIV expression and integration sites reveals robust viral expression across diverse chromatin environments [0.03%]
单细胞HIV表达和整合位点分析揭示了不同的染色质环境下病毒表达的稳健性
Yun Ma,Jackson J Peterson,David M Margolis et al.
Yun Ma et al.
Entry of HIV into latency is likely determined by a combination of factors, including stochastic fluctuations in the viral Tat protein during infection, as well as the transcriptomic phenotype of the host cell. Determining the impact of the...
Association between phenotypes and genotypes of antimicrobial resistance in E. coli and Salmonella isolates from retail chicken meat and live bird market sewage in Bangladesh [0.03%]
孟加拉国零售鸡肉和活禽市场污水中大肠杆菌和沙门氏菌分离株的抗菌药物耐药表型与基因型的关系研究
Mst Sonia Parvin,Sudipta Talukder,Sayra Tasnin Sharmy et al.
Mst Sonia Parvin et al.
Retail chicken meat contaminated with Escherichia coli and Salmonella represents a significant global public health concern, particularly in developing countries like Bangladesh. The presence of antimicrobial-resistant (AMR) strains in reta...
Ecological and evolutionary implications of a mobile genetic element-richhaloarchaeon with unique osmotic resilience [0.03%]
富含移动遗传元件的独特耐渗压盐 Haloarchaeon 的生态及进化意义
Yimin Ni,Wanling Bi,Hao Yu et al.
Yimin Ni et al.
We isolated a novel halophilic archaeon, strain DSL9, representing the proposed new species Haloliberatus hailidukes gen. nov., sp. nov., from Dishui Lake, China. Unlike most obligate halophiles, DSL9 survives in low salinity, even distille...
Targeted amplicon sequencing for enhanced detection of spiked Shiga toxin-producing Escherichia coli in ready-to-eat romaine lettuce: a proof-of-concept study [0.03%]
一种概念验证研究：对现成可食生菜中掺入的志贺毒素产生型大肠杆菌进行扩增子靶向测序以增强其检测率
Isha Patel,Mark Mammel,Jayanthi Gangiredla et al.
Isha Patel et al.
The early and accurate detection of low-level pathogenic and indicator organisms in fresh produce is critical for preventing widespread foodborne outbreaks. Contamination of leafy greens with foodborne pathogens, such as Shiga toxin-produci...
From diversity to dominance: how salt and CO₂ shape LAB-dominated ecosystems in vegetable fermentations [0.03%]
从多样到主导——盐和CO₂如何塑造蔬菜发酵中乳酸菌占优势的生态系统
Tom Eilers,Tim Van Rillaer,Stijn Wittouck et al.
Tom Eilers et al.
Research on microbial ecosystems is often challenging due to the high diversity of microbial taxa present and the complexity of controlling environmental variables. Fermented foods offer simpler and more reproducible model ecosystems in whi...
Genome features and antimicrobial resistance of Trueperella pyogenes isolated from deceased farmed white-tailed deer (Odocoileus virginianus) in Florida [0.03%]
来自佛罗里达州养殖白尾鹿的Trueperella pyogenes的基因组特征和抗微生物药物耐药性
An-Chi Cheng,Ting Liu,Austin C Surphlis et al.
An-Chi Cheng et al.
Trueperella pyogenes is a gram-positive, facultatively anaerobic bacterium known to cause infections in both domestic and wild animals, including white-tailed deer (WTD; Odocoileus virginianus). However, limited studies have focused on its ...