Benefits of three consecutive sputum inductions using nebulized racemic salbutamol versus hypertonic saline in smear-negative or sputum-scarce pulmonary tuberculosis patients: a prospective randomized, double-blind study [0.03%]
连续三次雾化吸入沙丁胺醇合剂与高渗盐水诱导痰液在菌阴或少痰肺结核患者中的优势：一项前瞻性随机双盲研究
Warangkana Keeratichananont,Suriya Keeratichananont,Natthaphon Ubonsutvanich et al.
Warangkana Keeratichananont et al.
Although, sputum induction (SI) with hypertonic saline increases the diagnostic yield for suspected pulmonary tuberculosis (PTB) in patients with smear-negative microscopy, but, it carries adverse effects (AEs), particularly bronchospasm. T...
Leaf- and canopy-level chlorotic symptom variations are associated with differential Candidatus Liberibacter asiaticus infection patterns in Ponkan mandarin under field conditions [0.03%]
在果园条件下，叶部和冠层黄化症状的变化与凹皮柑橘中“Candidatus Liberibacter asiaticus”的不同感染模式相关
Yu-Min Wu,Chia-Ching Chu
Yu-Min Wu
Ponkan mandarin (Citrus reticulata cv. Ponkan) is an important fruit crop planted across different countries. One of its most devastating diseases is citrus huanglongbing (HLB), which is associated with infection by the bacterium Candidatus...
Decreased carbohydrate sources reduce microbial diversity and taxonomic redundancy in the murine gut [0.03%]
碳水化合物来源减少会降低小鼠肠道微生物多样性和分类学冗余度
Clara Flores,Anna M Seekatz
Clara Flores
Changes in dietary composition, particularly in carbohydrate diversity, alter the resource environment of the gut microbiome, with downstream effects on community assembly and diversity. However, the extent to which reducing the number of d...
Identifying effective cryoprotection agents for non-model bacterial species [0.03%]
识别非模型细菌种类的有效冷冻保护剂
Ruth Wright,Bhuwan Abbot,Taylor Yonemura et al.
Ruth Wright et al.
Host-associated bacteria live amongst eukaryotes within varied niches and form relationships ranging from facultative to obligate. With advancement in the studies of such symbiotic associations, fastidious bacteria are increasingly becoming...
Strain-level genomic analysis of Staphylococcus epidermidis across multiple body sites in healthy females [0.03%]
健康女性多部位表皮葡萄球菌的株水平基因组分析
Sandra Jablonska,Niru Shanbhag,Alex Kula et al.
Sandra Jablonska et al.
Staphylococcus epidermidis is a ubiquitous skin commensal that also colonizes the nasal and oral cavities, as well as the gastrointestinal and urinary tracts. Although prior studies have found genetic variation between S. epidermidis from i...
Pacin, a novel bacteriocin from Pseudomonas strain 166, exhibits anti-MRSA activity with low toxicity and high therapeutic potential [0.03%]
假单胞菌株166的新 bacteriocin Pacin 对抗 MRSA 活性低毒性且高治疗潜力
Yu Wang,Xiaojia Fu,Yunjia He et al.
Yu Wang et al.
The emergence and rapid spread of methicillin-resistant Staphylococcus aureus (MRSA) pose a significant threat to public health, underscoring the urgent need for the development of effective antibacterial agents. Bacteriocins, as highly pro...
Antifolate agent aminopterin demonstrates potent anti-monkeypox virus activity in vitro and in vivo [0.03%]
抗folate药物氨基喋呤在体外和体内均表现出显著的抗猴痘病毒活性
Jing Wu,Meimei Duan,Lin Cheng et al.
Jing Wu et al.
The ongoing spread of the monkeypox outbreak underscores the urgent need for the development of effective therapeutics against the monkeypox virus (MPXV). Aminopterin is a classical antifolate agent known for its anti-tumor activity through...
Functional and structural characterization of a serine protease from Bacillus toyonensis co-expressed with short peptides from late embryogenesis abundant (LEA) proteins [0.03%]
来源于Bacillus toyonensis的丝氨酸蛋白酶与晚期胚生成丰富（LEA）蛋白质短肽共表达的功能和结构表征
Ammar Khazaal Kadhim Almansoori,Nurul Ain Syukriyah,Choo Yi Hang et al.
Ammar Khazaal Kadhim Almansoori et al.
The increasing demand for high-performance proteases in industrial applications necessitates strategies to enhance enzyme yield, stability, and functional robustness under extreme conditions. This study investigates a serine protease from B...
Extensive library of Ruminococcus gnavus phages revealing genomic and phenotypic diversity with novel clusters [0.03%]
大量的Ruminococcus gnavus噬菌体库揭示了具有新簇的基因组和表型多样性
Arata Sakiyama,Ayaka Washizaki,Keiko Inaba-Hasegawa et al.
Arata Sakiyama et al.
Ruminococcus gnavus is a prevalent member of human gut microbiota and is associated with inflammatory bowel disease. Phage-based microbiota engineering represents a promising approach for alleviating dysbiosis; however, knowledge regarding ...
Third-generation cephalosporin-induced L-form transition in Shigella sonnei reveals a virulence-survival trade-off underlying persistent infection [0.03%]
第三代头孢菌素诱导的宋内志贺菌L形式转换揭示了持续感染下的致病性-存活权衡关系
Sanjib Das,Arindam Mukherjee,Prolay Halder et al.
Sanjib Das et al.
Shigellosis remains a major global health burden, and the increasing prevalence of multidrug-resistant (MDR) Shigella strains is complicating effective antibiotic therapy. Bacteria may survive antibiotics by transitioning into cell wall-def...