Synergistic activity of caspofungin and posaconazole against Candida (Candidozyma) auris biofilms based on phenotypic, transcriptomic, and in vivo insights [0.03%]
卡泊芬净和泊沙康唑对白色念珠菌生物膜的协同活性：基于表型、转录组学和体内研究的见解
Fruzsina Kovács,Andrea Harmath,Dávid Balázsi et al.
Fruzsina Kovács et al.
Candida (Candidozyma) auris is an emerging multidrug-resistant fungal pathogen capable of establishing persistent skin colonization, contaminating the environment, and causing nosocomial outbreaks associated with high mortality rates. Conve...
Cumulative cefepime exposure in cancer patients is associated with an increased risk of ertapenem non-susceptible, meropenem susceptible Enterobacterales bacteremia [0.03%]
累积头孢吡肟暴露与癌症患者发生对厄他培南耐药但对美罗培南敏感的肠杆菌血流感染风险增加有关
Alex V Stabler,William C Shropshire,Allyson Young et al.
Alex V Stabler et al.
Carbapenem resistance in non-carbapenemase producing Enterobacterales can display susceptibility discordance (e.g., ertapenem-non-susceptible, meropenem-susceptible), often in patients with prior antimicrobial use. We aim to characterize ri...
Mapping the geodispersal and evolutionary dynamics of regional Nipah virus strain in Bangladesh [0.03%]
绘制孟加拉国地方性 nipah病毒株地理分散和进化动力学地图
Md Mahfuzur Rahman,Shahreen Rahman,Samiur Rahim et al.
Md Mahfuzur Rahman et al.
Nipah virus (NiV) is a zoonotic pathogen causing severe respiratory and neurological disease in humans, with high fatality rates, primarily transmitted from fruit bats to humans through bat-tainted raw date palm sap and fruits. NiV outbreak...
Comparison of outcomes of KPC-producing Enterobacterales bloodstream infections treated with ceftazidime-avibactam and other conventional antibiotics: retrospective single-center study [0.03%]
头孢他啶-阿维巴坦与传统抗生素治疗产KPC肠杆菌血流感染的疗效比较：单中心回顾性研究
Kyungsup Kwon,So Yun Lim,Euijin Chang et al.
Kyungsup Kwon et al.
Ceftazidime-avibactam (CZA) was introduced in South Korea in July 2023, but regional data on its clinical efficacy, treatment outcomes, and microbiological characteristics of bloodstream infections (BSIs) caused by Klebsiella pneumoniae car...
In vitro activity of MRS-2541, a novel MetRS inhibitor, against a selection of resistant gram-positive organisms associated with serious hospital infections [0.03%]
一种新型蛋氨酸瑞森酸合成酶抑制剂MRS-2541对医院感染相关多重耐药阳性菌的体外活性研究
John Domagala,Seyedhameneh Jahanbakhsh,Angela K Mendez et al.
John Domagala et al.
New antibacterials are still needed to treat serious gram-positive hospital infections, including acute bacterial skin and skin structure infections and bloodstream infections. MRS-2541 is a novel type 1 methionyl-tRNA synthetase inhibitor ...
Comparative evaluation of sputum microscopy and Xpert MTB/RIF assay for tuberculosis detection and rifampicin resistance surveillance in Biratnagar, Nepal [0.03%]
尼泊尔比拉特纳格尔市痰涂片显微镜检查与Xpert MTB / RIF检测技术在结核病诊断及利福平耐药监测方面的比较评估研究
Shristy Ojha,Akash Adhikari,Sujan Adhikari et al.
Shristy Ojha et al.
Tuberculosis (TB) control in Nepal faces persistent challenges due to underdiagnosis and increasing drug resistance. This study assessed the diagnostic performance of the Xpert MTB/RIF assay compared with conventional smear microscopy and e...
Fatty acid transporter protein isoform 2 (FATP2) inhibitor lipofermata inhibits Zika virus replication and blocks fatty acid uptake in SH-SY5Y neuroblastoma cell line [0.03%]
长链脂肪酸转运蛋白抑制剂lipofermata通过抑制Zika病毒脂肪酸摄取限制Zika病毒感染神经元细胞生长分化能力下降
Songkran Thongon,Chompunuch Boonarkart,Thanyaporn Sirihongthong et al.
Songkran Thongon et al.
Zika virus (ZIKV) infection in adults is typically mild and self-limiting, but infection during pregnancy can cause fetal and neonatal microcephaly. No approved drugs or vaccines currently exist. ZIKV hijacks host lipid homeostasis to facil...
A visible assay for evaluating the inhibitory activity of drug and antibody against HBV infection [0.03%]
一种评估药物和抗体对HBV感染抑制活性的可视化方法
Hu Yan,Yuxiao Li,Congcong Liu et al.
Hu Yan et al.
Viral infectivity detection assays play an important role in the quantitative titers of virus and the effect of drugs and antibodies against virus infection. However, detecting the infectivity of hepatitis B virus (HBV) via conventional pla...
Comparative evaluation of viability PCR reagents highlights the superior efficacy of PMAxx azo dye for bacterial and viral viability discrimination using real-time and digital PCR [0.03%]
对比评价PCR试剂盒并强调PMAxx偶氮染料在实时及数字PCR中区分细菌和病毒活性的优越性
Tiwawan Hongsibsam,Jarunee Prasertsopon,Pilaiwan Siripurkpong et al.
Tiwawan Hongsibsam et al.
Viability PCR (vPCR) distinguishes viable from nonviable microorganisms by suppressing amplification from structurally compromised cells or virions. This study compared three viability reagents-ethidium monoazide (EMA), propidium monoazide ...
Evaluation of the performance of a novel chemiluminescence immunoassay for cryptococcal antigen detection [0.03%]
一种新型化学发光法检测隐球菌抗原性能评估
Ying Zhao,Lijiang Chen,Dingding Li et al.
Ying Zhao et al.
This study evaluated the diagnostic performance of a chemiluminescence immunoassay (CLIA) for detecting the Cryptococcus glucuronoxylomannan (GXM) antigen and assessed its agreement with the U.S. Food and Drug Administration (FDA)-approved ...