Early-life development of the microbiome and resistome in antibiotic-naïve dairy calves [0.03%]
无抗生素处理乳仔牛微生物组和耐药组的早期发育特征
Maggie M Murphy,Lee J Pinnell,Enrique Doster et al.
Maggie M Murphy et al.
This study aimed to characterize early-life changes in the fecal microbiome and resistome of calves. Fecal samples were collected from 49 Holstein heifers born and raised at a large organic dairy in Texas without antimicrobial drug exposure...
Multi-omics analysis reveals the alterations in the tumor microbiome and metabolome associated with cervical cancer lymph node metastasis [0.03%]
多组学分析揭示了宫颈癌淋巴结转移相关的肿瘤微生物组和代谢组的改变
Ting Zhang,Yiduo Yu,Chunyan Zhang et al.
Ting Zhang et al.
Lymph node metastasis (LNM) is the primary mode of cervical cancer (CC) metastasis and is associated with a poorer prognosis. A comprehensive understanding of the underlying mechanisms driving LNM is critical to improving CC patient outcome...
Development of a high-throughput growth assay for bacteria or yeasts using an agar-based insoluble carbon source immobilization method [0.03%]
一种使用基于琼脂的不可溶碳源固定化方法的高通量细菌或酵母生长测定的发展
Jiabao Liang,Isabella S Naimi,Achala Narayanan et al.
Jiabao Liang et al.
Polysaccharide degradation by microorganisms is essential in driving global nutrient cycling, developing renewable fuels or chemicals, and promoting human gut health. However, complex polysaccharides are often insoluble, making it challengi...
Metabolic reprogramming in the enterocytes of neonatal piglets infected with porcine epidemic diarrhea virus: integrated omics and multi-batch analysis highlight alterations in lipid metabolism and potential therapeutic targets [0.03%]
仔猪感染流行性腹泻病毒后肠上皮细胞代谢重组：整合组学和多批次分析揭示了脂质代谢的改变及潜在治疗靶点
Mengjun Wu,Qian Zhang,Xintao Shi et al.
Mengjun Wu et al.
Porcine epidemic diarrhea (PED) is a severe viral disease caused by the porcine epidemic diarrhea virus (PEDV), leading to huge economic losses in the swine industry. Identifying therapeutic targets has long been a critical challenge in pre...
Temporal transcriptomics identifies early-response and infection-condition-specific modules guiding host-directed anti-EBOV therapeutics [0.03%]
时间转录组学鉴定早期反应和感染条件特异性模块指导宿主导向的抗埃博拉病毒治疗
Nailou Zhang,Shaolong Zheng,Xiaoxiao Gao et al.
Nailou Zhang et al.
Ebola virus (EBOV) is among the most lethal human pathogens, yet effective treatment options remain limited. While extensive efforts have elucidated the functions of viral proteins, the temporal orchestration of host transcriptional respons...
Regional environmental heterogeneity under contrasting anthropogenic pressures has differential effects on particle-attached than free-living bacteria communities in coral reef waters [0.03%]
人类活动压力下的区域环境异质性对珊瑚礁水域中附着在颗粒物上的和自由生活的细菌群落具有不同的影响
Dan He,Heng Wang,Lijuan Ren et al.
Dan He et al.
Coral reef ecosystems are facing increasing environmental and anthropogenic pressures worldwide. Their health and prosperity depend, at least partly, on the surrounding water environment, where the free-living (FL) and particle-attached (PA...
A cross-sectional analysis of the vaginal microenvironment in rheumatoid arthritis [0.03%]
类风湿性关节炎阴道微环境的横断面分析研究
Marlyd E Mejia,Savannah Bowman,Jessica Lee et al.
Marlyd E Mejia et al.
The human microbiota is implicated in the development and progression of rheumatoid arthritis (RA). Given the increased RA burden in women and well-known correlations between the vaginal microbiota and local inflammation, we seek to underst...
Genetic variations and accelerated growth at low temperatures in a Listeria monocytogenes isolate [0.03%]
单增李斯特氏菌基因变异及其在低温下的加速生长现象
Katrina L Counihan,Nirosha Ruwani Amarasekara,Joshua B Gurtler et al.
Katrina L Counihan et al.
Listeria monocytogenes contamination of fresh-cut produce poses a threat to consumers due to its high mortality rate in humans. Because it is widespread in the environment, as well as able to grow and survive in harsh conditions, such as lo...
Genome-based insights into metal co-resistance in Amazonian mercury-resistant bacteria: ecological lifestyle and biosafety implications for bioremediation [0.03%]
基于基因组的见解：亚马逊汞抗性细菌中金属共抗性的生态生活方式及生物安全修复的含义
Maria Camila Escobar,Juan Pablo Niño-Garcia,Alejandro Acosta-González et al.
Maria Camila Escobar et al.
Mercury (Hg) pollution from artisanal gold mining represents a serious environmental and public health problem, especially in the Amazon Basin. Although mercury-resistant bacteria provide significant detoxification potential, their deployme...
High-resolution metabolomic analysis of stool reveals expanded biomarkers of C. difficile colitis and insights into pathophysiology [0.03%]
高分辨率代谢组分析揭示了C. difficile结肠炎的扩展生物标志物并提供了病理生理学见解
Nirja Mehta,Vincent Guzzetta,Ken H Liu et al.
Nirja Mehta et al.
Clostridioides difficile infection (CDI) is facilitated by gut microbiome disruption and associated metabolic disturbances. While many prior studies have focused on the microbial composition of CDI stool, fewer have explored the fecal metab...