CasCADE: Cas -C RISPR Automated Design and Evaluation for targeted gRNA detection assays [0.03%]
CasCASCADE：用于靶向gRNA检测 assay的Cas-C RISPR 自动设计和评估系统
Colin Price,Julie L Lucas,Phil Davis et al.
Colin Price et al.
The adaptation of CRISPR technologies for molecular detection marks a significant advancement in the field of biosurveillance and infectious disease response. CRISPR-based detection systems offer superior specificity and sensitivity compare...
Spatial ecology of the Capnocytophaga genus in the human oral cavity [0.03%]
人类口腔中Capnocytophaga属的时空生态学研究
Jonathan J Giacomini,Julian Torres-Morales,Floyd E Dewhirst et al.
Jonathan J Giacomini et al.
The human oral microbiome, a complex ecosystem of niche-specific communities influenced by local ecological factors, plays a critical role in health and disease. Capnocytophaga species are prevalent in the human mouth, often abundant in den...
In vitro activity of robenidine analogue NCL195 against methicillin-resistant Staphylococcus pseudintermedius [0.03%]
类罗贝啶化合物NCL195对耐甲氧西林中间型金黄色葡萄球菌的体外活性研究
Sayara Bista,Hang Thi Nguyen,Tatiana P Soares da Costa et al.
Sayara Bista et al.
The rise of difficult-to-treat infections among companion animals, particularly the increasing incidence of methicillin-resistant Staphylococcus pseudintermedius (MRSP) in dogs poses significant challenges for effective treatment options in...
Combinatorial effects of a novel SHV-248 variant, NDM-5, and ompK35 deficiency drive high-level cefiderocol resistance in Klebsiella pneumoniae [0.03%]
新型SHV-248变异、NDM-5及ompK35缺陷的联合作用可驱动肺炎克雷伯菌高度耐药于头孢地尔
Chuwen Zhao,Yuxuan Liu,Hanxu Hong et al.
Chuwen Zhao et al.
Cefiderocol holds significant therapeutic value against metallo-β-lactamase-producing Enterobacterales. However, reduced susceptibility to cefiderocol in NDM-producing strains is increasingly observed. This study elucidated the mechanism o...
Gut microbiota composition and tumor immune features in meningioma patients [0.03%]
脑膜瘤患者的肠道微生物群组成与肿瘤免疫特征关系研究
Kai Yin,Shuai Ma,Jichao Yang et al.
Kai Yin et al.
Meningiomas are prevalent intracranial tumors with poorly understood extraneural drivers. While the gut-brain axis influences neuro-oncogenesis, meningioma-specific gut microbiome alterations and their clinical implications remain uncharact...
Yoshiko Miyahara,Takehisa Yano
Yoshiko Miyahara
Perseverance is a phenotype in which a small subpopulation of bacteria continues to divide for hours in the presence of antimicrobial concentrations that inhibit bulk population growth, without acquiring genetic resistance. Perseverance has...
Analytical comparison of over-the-counter multiplex tests for influenza A, influenza B, and SARS-CoV-2 [0.03%]
市售流感A、流感B和新型冠状病毒多重检测试剂盒的分析比较
Sarah Lohsen,Yana Hoy-Schulz,Annie Taing et al.
Sarah Lohsen et al.
Over-the-counter (OTC) lateral flow tests for respiratory viruses have newly emerged since the beginning of the coronavirus disease 2019 (COVID-19) pandemic and are increasingly available to consumers. While all marketed tests have met stan...
Bacillus velezensis LUB-8 bioaugmentation: a strategy for lactic acid reduction in pit mud of Chinese nong-xiang baijiu [0.03%]
芽孢杆菌LUB-8生物增强法降低浓香型白酒窖泥中乳酸策略研究
Guiqiang He,Qingwei Feng,Kebu Jigu et al.
Guiqiang He et al.
Excessive accumulation of lactic acid in pit mud (PM) is a key issue causing PM aging and affecting the quality of Chinese nong-xiang baijiu. This study proposes a biofortification strategy involving inoculation with Bacillus velezensis LUB...
A distinct IgM immunoblot signature differentiates neurosyphilis from latent syphilis [0.03%]
一种明确的IgM免疫印迹特征可将神经梅毒与潜伏梅毒相区分
Xue Yang,Jiahui Shen,Ming Liang et al.
Xue Yang et al.
Accurately differentiating neurosyphilis (NS) from latent syphilis (LS) is essential, as it directly guides therapeutic decisions and prevents devastating neurological complications. However, this differentiation remains a significant clini...
Paclitaxel-induced tubulin dysfunction stalls parasite development: synergistic potential with artemisinin against resistant strains [0.03%]
紫杉醇诱导的微管功能障碍阻止寄生虫发育：与青蒿素联合对抗耐药株的潜力
Yongxin Tang,Xinyu Zhang,Xiaohui He et al.
Yongxin Tang et al.
In this study, paclitaxel (PTX), a well-characterized microtubule-stabilizing agent, was systematically investigated for its antimalarial potential against drug-resistant Plasmodium falciparum. In vitro experiments demonstrated that PTX pot...