Phylodynamics and molecular epidemiology of the respiratory syncytial virus fusion protein in China [0.03%]
中国呼吸道合胞病毒融合蛋白的谱系动力学和分子流行病学研究
Muhammad Nabeel Amjad,Jing Wang,Bei Shen et al.
Muhammad Nabeel Amjad et al.
Respiratory syncytial virus (RSV) infections have a high prevalence in young children, immunocompromised adults, and elderly, raising global concerns. Global RSV surveillance infers an 8%-27% mortality rate in preterm-born children, with 2....
IL-17B protects against uropathogenic E. coli-induced kidney injury via macrophage infiltration modulation [0.03%]
白细胞介素17B通过调节巨噬细胞浸润抵抗致尿路感染大肠杆菌引起的肾损伤
Changying Wang,Min Liu,Luyue Wang et al.
Changying Wang et al.
Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are prevalent among women. UPEC infection can lead to kidney injury, and currently, there are no effective methods to mitigate this damage. Previous studies hav...
Phenotypic heterogeneity shapes phage resistance and cocktail efficacy in Klebsiella pneumoniae [0.03%]
表型异质性影响肺炎克雷伯菌的噬菌体抗性和鸡尾酒疗效
Lucas Mora-Quilis,Rafael Sanjuán,Pilar Domingo-Calap
Lucas Mora-Quilis
The emergence of phage-resistant bacteria poses a significant challenge to the success of phage therapy. Although phage cocktails can delay resistance, their efficacy relies on the ability to target the full spectrum of resistant variants, ...
Host genotype and environmental factors differentially shape the black piranha's gill microbiota [0.03%]
宿主基因型和环境因素不同地塑造黑锯齿鱼的鳃微生物群
Alizée Thomas,François-Étienne Sylvain,Eric Normandeau et al.
Alizée Thomas et al.
Gills play a crucial role in teleost fish, contributing to respiration, osmoregulation, and immunity. The mucus they secrete, and their associated microbiota, support these physiological functions and serve as a first line of defense agains...
Synergistic effects of halo-plaque forming phage cocktails against polymicrobial Acinetobacter baumannii and Staphylococcus aureus [0.03%]
针对多微生物的不动杆菌和金黄色葡萄球菌的噬斑形成噬菌体鸡尾酒的协同效应
Ampapan Naknaen,Arrita Rueangrit,Wanna Sudhikaran et al.
Ampapan Naknaen et al.
Antimicrobial resistance is a growing global health crisis, with polymicrobial infections caused by Acinetobacter baumannii and Staphylococcus aureus posing a significant healthcare challenge due to their synergistic virulence, multidrug re...
Prior immunity to seasonal influenza A(H3N2) virus confers varying levels of cross-protection against challenge with clade 2.3.4.4b A(H5N1), A(H7N9), or A(H9N2) virus in a ferret model [0.03%]
季节性流感A（H3N2）病毒的先前免疫在仓鼠模型中对同种型2.3.4.4B A（H5N1），A（H7N9）或A（H9N2）病毒的挑战提供不同的交叉保护水平
Xiangjie Sun,Jessica A Belser,Zhu-Nan Li et al.
Xiangjie Sun et al.
Evaluating how prior immunity to seasonal influenza viruses influences subsequent zoonotic influenza A virus (IAV) infection in animal models is critical for pandemic preparedness. In this study, we investigated the cross-protective effect ...
Integrated multi-omics analysis reveals gut dysbiosis and altered energy metabolism in Chinese ALS patients [0.03%]
整合多组学分析揭示了中国ALS患者的肠道微生态失调和能量代谢改变
Xueli Ma,Zewei Jiang,Tianhua Yang et al.
Xueli Ma et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with a complex etiology. Emerging evidence implicates gut microbiota dysbiosis in ALS pathology via the gut-brain axis, yet the specific integrative profile of the gu...
Co-occurrence of the tigecycline resistance gene cluster tmexCD3-toprJ1 and verona integron-encoded metallo-β-lactamase (VIM) in a human-derived Pseudomonas sediminis isolate [0.03%]
产金属β-内酰胺酶(VIM)的假单胞菌塞迪门氏菌临床分离株中泰利霉素耐药基因簇tmexCD3-toprJ1的共存现象
Heng Shen,Aoxiao Chen,Chang Cai et al.
Heng Shen et al.
As the last line of defense against carbapenemase-producing Enterobacterales, the growing prevalence of tigecycline resistance poses a serious challenge to clinical therapy. Although tmexCD-toprJ clusters were initially described in Enterob...
Targeted Epstein-Barr virus capture sequencing identifies BBLF4-L322M as an independent prognostic variant in nasopharyngeal carcinoma [0.03%]
靶向捕获测序鉴定出EB病毒BBLF4-L322M变异是鼻咽癌独立预后因素
Shi Luo,Zongjian Huang,Nan Shi et al.
Shi Luo et al.
Epstein-Barr virus (EBV) is etiologically linked to nasopharyngeal carcinoma (NPC) and shows geographic heterogeneity. To determine whether viral genotype affects prognosis, we performed capture-based whole-genome sequencing of EBV from 114...
Revisiting cysteine protease function in Trypanosoma cruzi: implications for parasite egress and differentiation [0.03%]
美洲锥虫隐孢子虫蛋白酶功能再探：对寄生虫逸出和分化的影响
Sara De Grandis,Anne Niggli,Delia Bogenstätter et al.
Sara De Grandis et al.
Chagas disease is a major global health concern affecting millions of people worldwide, with limited therapeutic options in its chronic phase and no prophylactic vaccine. The causative agent, Trypanosoma cruzi, is a unicellular eukaryotic p...