Prospective study of vaginal samples for the detection of Gardnerella vaginalis and G. swidsinskii/leopoldii using Gardnerella agar in CO2 and anaerobic atmospheres [0.03%]
二氧化碳和厌氧环境中使用 Gardnerella 培养基检测阴道标本中 Gardnerella vaginalis 和 G. swidsinskii/leopoldii 的前瞻性研究
Irena Grmek Košnik,Ana Ribnikar,Ema Ogrizek et al.
Irena Grmek Košnik et al.
Gardnerella vaginalis is a key bacterium in the etiology of bacterial vaginosis (BV) and contributes to biofilm formation. Gardnerella is a facultative anaerobic bacterium, meaning it can grow both in the presence of oxygen and under anaero...
SMAP29: an antibacterial peptide that possesses anti-inflammatory and fast bactericidal actions against colistin-resistant gram-negative bacteria [0.03%]
具抗炎和快速杀菌作用的新型抗菌肽SMAP29对抗多粘菌素耐药革兰阴性菌效果优异
Ziyue Zeng,Mengjie Wei,Deyi Zhao et al.
Ziyue Zeng et al.
Multidrug-resistant (MDR) gram-negative bacteria (GNB) are threatening global public health. Since colistin (COL) is the last resort antibiotic for MDR gram-negative infections, the rise in colistin-resistant (COL-R) bacteria could pose r...
Molecular typing of rotaviruses in gastroenteritis cases detected in foreign-born children aged 0-5 years [0.03%]
在外国出生的0至5岁婴幼儿胃肠炎病例中轮状病毒分子分型研究
Salam Charbak,Mustafa Sağlam,Tekin Karsligil
Salam Charbak
Rotavirus is one of the causes of viral gastroenteritis in childhood. It is one of the most common causes of mortality and morbidity in developing countries. The objective of this study was to determine the molecular typing of rotaviruses i...
A cocktail of SARS-CoV-2 S stem helix domain and receptor binding domain human monoclonal antibodies prevents the emergence of viral escape mutants [0.03%]
一种SARS-CoV-2 S茎环域和受体结合域的人源单克隆抗体混合物可防止病毒逃逸变异株的出现
Yao Ma,Chengjin Ye,Michael S Piepenbrink et al.
Yao Ma et al.
Neutralizing antibodies (NAbs) targeting the spike (S) glycoprotein remain a crucial therapeutic strategy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, emerging viral variants have escaped all Food and Drug ...
Reducing culture underestimation in urine: flow cytometry-guided validation of low-dose DTT pre-treatment for biofilm dispersal [0.03%]
尿液中减少培养基低估：流式细胞仪引导的低剂量DTT预处理生物被膜分散的验证
Luigi Regenburgh De La Motte,Ivan Muradore,Fabiana Giarritiello et al.
Luigi Regenburgh De La Motte et al.
A substantial proportion of symptomatic patients with urinary tract infections (UTIs) have negative or low-count urine cultures despite clinically compatible presentations. Biofilm-associated bacterial aggregation and the presence of viable...
Urinary tract infections at an Australian sexual health service: bacterial etiologies, antibiotic susceptibilities, and antimicrobial prescribing patterns [0.03%]
澳大利亚性病治疗中心的泌尿系统感染：病因、抗生素敏感性和抗菌药物使用模式
S E Carter,E L Plummer,L A Vodstrcil et al.
S E Carter et al.
Urinary tract infections (UTIs) are one of the most common infections. Management of UTIs often involves empiric antibiotics, which can contribute to antibiotic overuse. We aimed to investigate the causative organisms, prevalence of antimic...
ICP1 bacteriophage treatment antagonizes colonization of the zebrafish larval intestine by Vibrio cholerae [0.03%]
丝状噬菌体ICP1通过拮抗霍乱弧菌来阻止斑马鱼幼鱼肠道定植
Adam Sidi Mabrouk,Jamie S Depelteau,Chiara Foini et al.
Adam Sidi Mabrouk et al.
Outbreaks of cholera pose a major threat to human health. Currently, antibiotics are the most effective treatment against the causative agent, the bacterium Vibrio cholerae. However, the use of antibiotics eventually leads to the emergence ...
The building blocks of phage therapy: from lytic phage identification to preclinical validation against antimicrobial-resistant critical priority bacteria [0.03%]
噬菌体治疗的基石：从溶菌噬菌体识别到针对抗菌药物耐药病原菌的临床前验证
Filipa F Vale
Filipa F Vale
The fight against antimicrobial resistance is bringing back phage therapy, consisting of the use of lytic phages against specific pathogenic bacteria. For this purpose, libraries of well-characterized lytic phages are crucial, as the phage-...
Risk factors for in vivo emergence of ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae and the associated resistance mechanisms: a case-control study [0.03%]
产KPC酶肺炎克雷伯菌中阿维巴坦耐药体外活体出现的风险因素及相应的耐药机制：病例对照研究
Chien Chuang,Szu-Yu Liu,Yu-Chien Ho et al.
Chien Chuang et al.
The emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (CZA-R KPC-Kp), primarily due to KPC variants, poses a growing challenge to clinical practice. We aimed to investigat...
Evaluation of COPAN FecalSwab and eSwab collection systems for the detection of C lostridioides difficile using the BD MAX Cdiff assay [0.03%]
评估BD MAX Cdiff检测试剂盒中C.difficile毒素基因的两种采样系统的性能：粪便采样海绵和eSwab采样棉签
Kelly Waters,Keltie Baldwin,Sarah Marttala et al.
Kelly Waters et al.
Clostridioides difficile infection (CDI) requires accurate and timely diagnostic testing to guide treatment. Nucleic acid amplification tests (NAATs) offer high sensitivity and specificity, but most assays, including the Health Canada-appro...