Characterization of novel macrophage cell lines derived from goat and sheep blood and their susceptibility to ruminant virus infections [0.03%]
绵羊和山羊血液来源的新型巨噬细胞系的特征及其对反刍动物病毒易感性的研究
Rina Ikeda,Misako Konishi,Tohru Yanase et al.
Rina Ikeda et al.
Macrophages are present in all vertebrate tissues and play a key role in both the prevention and pathogenesis of infectious diseases. In vitro cultures of macrophages provide a valuable tool for studying the innate immune functions of macro...
Dual human lung models reveal compartment-specific activity of anti-tuberculosis drugs and host-directed therapies [0.03%]
双人类肺模型揭示了抗结核药物和宿主导向疗法的隔室特异性活性
Caio César Barbosa Bomfim,Natacha Faivre,Thomas Benoist et al.
Caio César Barbosa Bomfim et al.
Tuberculosis (TB) remains a major global health challenge that requires new therapeutic strategies to improve drug efficacy, shorten treatment duration, prevent drug resistance, and limit Mycobacterium tuberculosis (Mtb) persistence. Here, ...
Ursodeoxycholic acid inhibits feline infectious peritonitis virus infection through activating JAK-STAT signaling pathway-induced type I interferon [0.03%]
鹅去氧胆酸通过激活JAK-STAT信号通路诱导I型干扰素抑制猫传染性腹膜炎病毒感染
Yi Zhong,Zhiwei Sun,Ziyan Song et al.
Yi Zhong et al.
Feline infectious peritonitis virus (FIPV), a highly pathogenic subtype of feline coronavirus, is characterized by antigenic variability and immune evasion, resulting in limited efficacy of existing clinical therapeutic regimens. In recent ...
Unveiling hidden microbial diversity in Mars 2020 mission assembly cleanrooms with molecular insights into the persistence and perseverance of novel species defying metagenome sequencing [0.03%]
揭秘火星2020任务装配洁净室中的隐秘微生物多样性并从分子角度揭示违背元基因组测序的新物种的持久性和毅力
Shobhan Karthick Muthamilselvi Sivabalan,Varsha Vijayakumar,Pratyay Sengupta et al.
Shobhan Karthick Muthamilselvi Sivabalan et al.
NASA cleanrooms, which are critical for assembling space mission components, are maintained under stringent decontamination protocols to minimize biological contamination. These environments are characterized by nutrient-poor and oligotroph...
Dengue-specific T-cell memory following natural infection: a comparative analysis between people living with HIV and HIV-negative individuals [0.03%]
HIV感染者和非感染者登革热特异性T细胞记忆的比较分析
Francesca Lombardi,Antonio Abatino,Pierluigi Francesco Salvo et al.
Francesca Lombardi et al.
People living with HIV (PLWH) represent a population of particular interest in the context of arboviral infections. This observational study aimed to evaluate and compare the magnitude and functionality of dengue virus (DENV)-specific T-cel...
KEGG orthology-based machine learning reveals functional determinants of antimicrobial resistance in Acinetobacter baumannii [0.03%]
基于KEGG同源性的机器学习揭示了鲍曼不动杆菌抗菌药物耐药性的功能决定因素
Zhihang Zheng,Bei Jiang,Abebe Mekuria Shenkutie et al.
Zhihang Zheng et al.
Antimicrobial resistance represents a critical global health threat, with Acinetobacter baumannii classified as a priority pathogen due to its extensive multidrug resistance. Currently, antimicrobial susceptibility testing relies on phenoty...
Identification and drug resistance profiling of Mycobacterium orygis from an African elephant using whole-genome sequencing [0.03%]
利用全基因组测序鉴定并表型分析来自一头非洲象的瘤胃分枝杆菌及其耐药性
Hassan Ghayas,Javaria Ashraf,Noureen Saeed et al.
Hassan Ghayas et al.
Tuberculosis (TB) caused by members of the Mycobacterium tuberculosis complex (MTBC) has been increasingly reported in wildlife and captive animals, posing zoonotic risks. Accurate diagnosis and speciation are essential to trace the infecti...
Microbiome in women with endometriosis and the in vitro effects of Lactobacillus reuteri on human endometrium [0.03%]
子宫内膜异位症女性的菌群及罗伊氏乳杆菌体外对人子宫内膜的影响
Jae Hoon Lee,Gee Soo Jung,Kyungmin Kim et al.
Jae Hoon Lee et al.
Endometriosis (EMS) is a chronic inflammatory disorder affecting ~10% of reproductive-age women, with increasing evidence implicating the microbiome in its pathogenesis through immunomodulation and estrogen metabolism. This study investigat...
Optimized use of the FilmArray Meningitis/Encephalitis panel for early discontinuation of antibiotic therapy [0.03%]
FilmArray脑膜炎/脑炎检测试剂盒的优化应用以实现抗生素的早期停用
Nathan Nicolau-Guillaumet,Marin Moutel,Chloé Plouzeau-Jayle et al.
Nathan Nicolau-Guillaumet et al.
Suspected meningitis/encephalitis cases require prompt empirical antimicrobial therapy. Syndromic diagnostics like the FilmArray Meningitis/Encephalitis (FAME) panel offer rapid results and are increasingly used despite high costs. This stu...
PRV-delgE/gI/TK immunization preserves blood-brain barrier integrity and limits CNS injury following intracerebral PRV challenge [0.03%]
PRV-delgE/gI/TK免疫接种可保持血脑屏障的完整性并在颅内感染后限制中枢神经系统损伤
Tong Xu,Baoling Liu,Hanyu Li et al.
Tong Xu et al.
Pseudorabies virus (PRV) causes rapidly progressive and often fatal encephalitis in both natural and non-natural hosts, making the development of effective preventive strategies critically important. Among current vaccine candidates, the tr...