Evidence that increased azole persistence and stress resistance precede the in vivo evolution of azole resistance in Aspergillus fumigatus [0.03%]
Endrews Delbaje,Laís Pontes,Marcela Savoldi et al.
Endrews Delbaje et al.
Aspergillus fumigatus is the major causative agent of human aspergillosis. Azoles are the first-line therapy, but resistance is increasing. Here, we characterized voriconazole persistence by screening a global collection of 495 clinical and...
SARS-CoV-2 nonstructural protein 3 remodels the phosphorylation of target proteins via protein-protein interactions [0.03%]
Hui Yang,Daxin Peng,Luis Martinez-Sobrido et al.
Hui Yang et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), triggered a global pandemic with a significant impact on human health. The molecular basis of its pathogenicity remain...
Impact of switching from manual to automated aerobic blood culture on bacteremia diagnosis in Lao PDR [0.03%]
Risara Jaksuwan,Mavuto Mukaka,Phonelavanh Phoumin et al.
Risara Jaksuwan et al.
Funding for antimicrobial resistance surveillance has led to more laboratories in low-resource settings switching to automated blood culture. There is limited evidence for the impact of switching from manual to automated blood culture in lo...
Yibing Lan,Cheng Wu,Peng Du et al.
Yibing Lan et al.
Our recent study showed that lat1, which encodes L-type amino acid transporter 1 (Lat1) was centrally positioned in the gene co-expression network of a Candida albicans (C. albicans) infection model of cell culture and suggested that this g...
An integrated centrifugation-washing-lysis method significantly improves microbiological diagnosis of spontaneous bacterial peritonitis [0.03%]
Yihe Zhao,Mingxi Hua,Chen Chen et al.
Yihe Zhao et al.
Culture-negative spontaneous bacterial peritonitis (SBP) remains a major diagnostic challenge in patients with cirrhotic ascites, largely due to prior antibiotic exposure, low bacterial burden, and phagocytosis of bacteria. To address these...
N-acetylglucosamine utilization and impact on antibiotic susceptibility, oxidative stress tolerance, and swimming in Stenotrophomonas maltophilia [0.03%]
Chun-Hsing Liao,Hsu-Feng Lu,Shao-Chi Wu et al.
Chun-Hsing Liao et al.
N-acetylglucosamine (GlcNAc) is an amino sugar that serves as a structural component, nutrient source, and signal molecule in bacteria. In this study, we sought to identify the genes involved in GlcNAc utilization in Stenotrophomonas maltop...
High-risk human papillomavirus genotype distribution, cytological abnormalities, and associated factors among Ethiopian women: a multicenter study [0.03%]
Sisay Tadele,Amelework Yilema,Belete Woldesemayat et al.
Sisay Tadele et al.
Persistent infection with high-risk human papillomavirus (hr-HPV) leads to cervical cancer (CC), the second most common cancer among women in Ethiopia. Understanding the genotype distribution of hr-HPV is essential for effective prevention ...
Juan Pablo Jaworski
Juan Pablo Jaworski
Bovine leukemia virus (BLV) encodes 10 mature microRNAs (miRNAs) that are highly expressed in infected cattle and have been implicated in oncogenic mechanisms. A potential association between BLV and human cancer remains controversial: whil...
Characterization of a conserved outer-membrane protein in non-typeable Haemophilus influenzae with an unidentified impact on phenotype [0.03%]
Ashley J Fraser,Oren Cooper,Brian M Forde et al.
Ashley J Fraser et al.
Non-typeable Haemophilus influenzae (NTHi) is an opportunistic bacterial pathogen of the human airway and is a cause of significant morbidity and mortality worldwide. No vaccine currently exists in part due to the incredible diversity and e...
Within-host co-evolution of KPC variants: plasmid-mediated dissemination of blaKpc-194 and blaKpc-33 in ST11-KL64 hypervirulent Klebsiella pneumoniae driving ceftazidime-avibactam resistance [0.03%]
Li Ding,Xiangbing Wu,Qiang Xie et al.
Li Ding et al.
KPC variants are the primary cause of treatment failure in patients with Klebsiella pneumoniae infections. This study reports the molecular mechanism by which two novel KPC variants (KPC-194 and KPC-33), isolated from a single patient, medi...