Comparative in vitro antimicrobial susceptibility profiles of clofazimine and pyrifazimine against clinical isolates of Mycobacterium tuberculosis in southwest China [0.03%]
氯法齐明和吡喹酮对我国西南地区临床分离株的体外抗菌敏感性比较研究
Ming Luo,Gang Zhou,Yunfan Fan et al.
Ming Luo et al.
Clofazimine (CFZ) is a key drug used to treat drug-resistant tuberculosis (DR-TB), while pyrifazimine (TBI-166) is an improved riminophenazine derivative with better pharmacokinetics. However, there is a lack of data on its susceptibility a...
Unraveling yeast diversity in food fermentation using ITS1-2 amplicon-based metabarcoding [0.03%]
基于ITS1-2靶区宏条形码测序解析发酵食品中酵母多样性研究
Ines Pradal,Thomas Gettemans,Stefan Weckx
Ines Pradal
A detailed characterization of the microbial ecosystem involved in the production processes of fermented foods is essential. Although fermented foods are an important part of the human diet and have seen an increasing interest nowadays, som...
First in vitro characterization of three oxytetracycline degradation products against avian pathogenic Escherichia coli isolates: antibacterial activity, formation in gizzard, and resistance gene profiling [0.03%]
首项体外实验表征三种土霉素降解产物对抗病鸡源大肠杆菌的活性：抗菌活性、肌胃形成及耐药基因谱分析
Wassel Zekri,Marie-Lou Gaucher,Maud de Lagarde et al.
Wassel Zekri et al.
Although oxytetracycline (OTC) has been widely used in poultry since 1950, comprehensive studies characterizing its degradation products for potential therapeutic applications have not been conducted. The aims of the present study were to e...
Dietary supplementation with fermented compound Chinese herbal medicine reshapes the gastrointestinal microbiota and enhances growth in suckling lambs [0.03%]
发酵复方中药饲料添加剂改善肠道菌群并促进哺乳期小羔羊生长性能
Yinglian Wu,Yan Wang,Rongyan Qin et al.
Yinglian Wu et al.
This study investigated the effects of a fermented compound Chinese herbal medicine (FCHM) on growth performance, antioxidant capacity, immune function, and gastrointestinal microbiota in suckling lambs. FCHM consisted of 10 herbs fermented...
Prevalence and genotypic distribution of virulence factor genes and antibiotic susceptibility profiles in clinical Pseudomonas aeruginosa isolates from a public hospital in Nanyang, China [0.03%]
中国南阳一家公立医院临床分离的铜绿假单胞菌毒力因子基因分布及耐药性分析
Si-Ping Zhang,Lin-Yu Li,Fei Wang et al.
Si-Ping Zhang et al.
Pseudomonas aeruginosa remains a critical global health concern, particularly in low- and middle-income countries, owing to its high carriage of diverse virulence factor genes (VFGs) and multidrug resistance. Here, we analyzed the prevalenc...
Ammonium ion concentration-dependent production of extracellular polysaccharides from glycerol by an oleaginous yeast: visualization of the producer cells [0.03%]
铵离子浓度依赖性的甘油产多糖的产生：以及通过透射电子显微镜观察其产生的分子机制研究（以含油酵母为材料）
Soyoka Takegawa,Chiaki Matsuzaki,Taiki Hikosaka et al.
Soyoka Takegawa et al.
In the oleochemical industry, a fat-splitting process is used to generate a methanol-free byproduct, oleochemical industrial waste, that includes crude glycerol. The oleaginous yeast Rhodotorula toruloides is a nonconventional yeast that is...
Characterization of Klebsiella phages PMBT12, PMBT63, and PMBT64 with functional insights into a Hoc-like, mucin-interacting protein of phage PMBT63 [0.03%]
具有类似Hoc的粘蛋白结合蛋白的噬菌体PMBT63的特性及其功能研究
Anna Ewertz,Erik Brinks,Gyu-Sung Cho et al.
Anna Ewertz et al.
Three novel Klebsiella phages, PMBT12, PMBT63, and PMBT64, were isolated and characterized. The phages revealed distinct morphologies, phylogenetic backgrounds, and a high degree of genomic divergence. PMBT12 and PMBT64 exhibited narrow hos...
Immune evasion, infectivity, and membrane fusion of SARS-CoV-2 variants LP.8.1.1, XEC.25.1, XFG, and NB.1.8.1 [0.03%]
SARS-CoV-2变异株LP.8.1.1、XEC.25.1、XFG和NB.1.8.1的免疫逃逸、感染性和膜融合能力
Feng Jiang,Miao Zheng,Long Gao et al.
Feng Jiang et al.
Emerging SARS-CoV-2 variants, with potentially enhanced immune evasion and transmissibility, pose a serious challenge to public health. This study provides a systematic characterization of the virological features of JN.1 descendant subvari...
Metabolomics profiling reveals changes in peptidoglycan and redox metabolism between ancient and modern Mycobacterium tuberculosis [0.03%]
代谢组学分析揭示了古菌和现代结核分枝杆菌肽聚糖及氧化还原代谢的差异
Ashleigh Cheyne,Elisabeth V Oskoui,Agnieszka Broda et al.
Ashleigh Cheyne et al.
Mycobacterium tuberculosis (Mtb), the cause of tuberculosis, kills over 1 million people worldwide each year. Mtb is classified into 10 distinct lineages, each harboring unique genetic changes that influence its survival, virulence, and tra...
Structures of the endophytic microbiota during heart rot development in Abies georgei var. smithii [0.03%]
Abies georgei 变种smithii 心腐病发病过程中内生微生物群落结构变化
Yi Li,Yaxin Kong,Jieting Li et al.
Yi Li et al.
Heart rot, caused by the basidiomycete fungus Fomitopsis subpinicola, poses a severe threat to the health of Abies georgei var. smithii, a keystone conifer dominating subalpine forests on Sejila Mountain in southeastern Xizang (Tibet), Chin...