Comparative evaluation of three commercial real-time PCR kits for direct detection of Mycobacterium tuberculosis complex and non-tuberculous mycobacteria from pulmonary and extrapulmonary clinical samples: experiences from a low-income and high-burden setting [0.03%]
三种商业实时PCR检测试剂盒直接检测临床样本中结核分枝杆菌复合群和非结核分枝杆菌的比较评估：来自低收入高负担国家的经验
Ángel Sebastián Rodríguez-Pazmiño,Elsy Carvajal,Bernardo Castro-Rodriguez et al.
Ángel Sebastián Rodríguez-Pazmiño et al.
The accurate and timely detection of Mycobacterium tuberculosis complex (MTBC) and non-tuberculous mycobacteria (NTM) remains a diagnostic challenge, particularly in extrapulmonary samples and low-resource settings. This study aimed to eval...
Effect of inhaled interferon-β1a on SARS-CoV-2 diversity and evolution [0.03%]
吸入干扰素-β1a对SARS-CoV-2多样性和进化的影响
Gregory E Edelstein,Tatum N Sass,Rinki Deo et al.
Gregory E Edelstein et al.
Interferon resistance has been implicated in SARS-CoV-2 escape from innate immunity, but exogenous interferon's impact on viral evolution and diversity is unknown. SNG001, an inhaled interferon-β1a treatment, was evaluated in the ACTIV-2/A...
VdPex30, a peroxisomal membrane protein, is involved in carbon metabolism, stress response, and pathogenicity of Verticillium dahliae [0.03%]
梵丹革菌VdPex30蛋白参与碳代谢、逆境响应和致病性
Zhiheng Zhang,Xiaoqing Liu,Wenfang Guo et al.
Zhiheng Zhang et al.
The fungus Verticillium dahliae causes Verticillium wilt in plants and has a broad host range. The peroxisomal membrane protein gene VdPex30 (VDAG_09094), identified in a host-induced gene silencing screen, plays a crucial role in fungal pa...
Integrative analysis of metabolome and transcriptome reveals new insights into the formation and regulation of major components of G. leucocontextum and G. lucidum [0.03%]
代谢组和转录组整合分析揭示了G. leucocontextum和G. lucidum主要成分的形成与调控新机制
Huijuan Sun,Xuefeng Zhu,Junli Zhang et al.
Huijuan Sun et al.
Ganoderma is a class of medicinal fungi with diverse medicinal effects, of which triterpenoids are one of the main pharmacologically active substances. In this study, sporocarps of two Ganoderma species (Ganoderma leucocontextum, a newly di...
Evaluation of a chromogenic medium, CHROMagar StrepA, for the detection of Streptococcus pyogenes in throat swab samples [0.03%]
评估CHROMagar StrepA培养基检测咽拭子样本中A群链球菌的效果
Romane Ponthot,Koukab Mahrous,Alexandre Grimmelprez et al.
Romane Ponthot et al.
Streptococcus pyogenes is a common bacterium that causes a wide spectrum of diseases, ranging from mild pharyngitis to life-threatening invasive infections. Rapid and accurate detection is essential for optimal patient management. In this s...
Host-directed antiviral strategy targeting prohibitins: Mel56 suppresses influenza A virus and severe acute respiratory syndrome coronavirus 2 via modulation of antioxidant pathways and mitochondrial function [0.03%]
靶向 prohibitin 抗病毒策略：Mel56 通过调节抗氧化途径和线粒体功能抑制流感病毒A型和SARS-CoV-2
Masaki Shoji,Rina Hashimoto,Canan G Nebigil et al.
Masaki Shoji et al.
Respiratory viruses, such as influenza A virus (IAV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remain major global health threats, and the emergence of drug-resistant variants underscores the urgent need for host-tar...
Dual-action antimicrobial peptide therapy: disrupting biofilm formation and targeting bacterial DNA for enhanced treatment of Pseudomonas aeruginosa endophthalmitis [0.03%]
针对绿脓杆菌眼内炎生物被膜形成和细菌DNA的双重抗菌肽治疗增强疗法
Yi Tang,Yan-Jie Zhou,Zi-Chao Ning et al.
Yi Tang et al.
Intraocular infections caused by Pseudomonas aeruginosa are difficult to treat due to bacterial biofilm-mediated antibiotic resistance. We used cationic polypeptide (XXYY) n to evaluate its effect and mechanism against Pseudomonas aeruginos...
Merilin Rosenberg,Sigrit Umerov,Carmen Marianne Teär et al.
Merilin Rosenberg et al.
Copper and silver are well-known and widely used antimicrobial metals that are often considered to employ diverse, overlapping biocidal mechanisms of action, and induce corresponding bacterial defense responses. Exposure to antimicrobial me...
Evaluation and comparison of three qPCR commercial assays and three automated platforms for the detection of monkeypox virus DNA [0.03%]
三种商业qPCR检测试剂盒和三种全自动分析平台检测猴痘病毒DNA的效果评估及比较研究
Marie Usal,Julien Andréani,Aurélie Truffot et al.
Marie Usal et al.
This study compared the analytical performance of three commercial real-time PCR assays for the detection of monkeypox virus (MPV) DNA, on their own platforms and/or on open platforms, were evaluated at the virology laboratory of Grenoble-A...
Lectin-Fc(IgG2a) fusion proteins binding to the cell wall of C. albicans cause structural, metabolic, oxidative, and other pleiotropic effects [0.03%]
葡糖基结合的凝集素-Fc融合蛋白对白色念珠菌细胞壁的作用及机制研究
Susana Ruiz Mendoza,Claudia Rodriguez de La Noval,Marina da Silva Ferreira et al.
Susana Ruiz Mendoza et al.
Candida albicans, an opportunistic fungal pathogen and the leading cause of hospital-acquired infections, exhibits diverse virulence factors that promote its survival within the human body. The rising incidence of multidrug resistance (MDR)...