Inoculation of Bacillus velezensis SD24 enhancing the accumulation of tea catechin secondary metabolites [0.03%]
枯草芽孢杆菌SD24诱导茶树次生代谢产物茶黄酮的积累
Liangliang Yu,Hongbo Li,Huilin Yu et al.
Liangliang Yu et al.
Tea (Camellia sinensis) is a globally significant economic crop, and its desirable quality and health benefits are largely credited to catechin derivatives. Plant growth-promoting rhizobacteria (PGPR), such as Bacillus velezensis, are well-...
Multi-omics characterization of new and aged Daqu reveals region-specific microbial succession and metabolic signatures in Maotai-flavor liquor fermentation [0.03%]
多组学揭示制曲龄和地域对大曲微生物演替及代谢特征的影响规律及其与茅香型白酒发酵品质的关系
Kejia Wang,Dongya Zhang,Ke Shen et al.
Kejia Wang et al.
Daqu is an essential fermentation starter that drives the formation of the characteristic flavor of Maotai-flavor liquor, yet the ecological and metabolic mechanisms underlying its regional differentiation and maturation remain poorly resol...
Pilot evaluation of a compact targeted next-generation sequencing with minimum biocontainment for rapid diagnosis of drug-resistant tuberculosis [0.03%]
耐药结核病快速诊断的靶向下一代测序检测方法评估研究
Radha Gopalaswamy,Ashok Kumar Shanmugavel,Bhargavi Subramanian et al.
Radha Gopalaswamy et al.
Next-generation sequencing is a more rapid and robust technique than phenotypic drug susceptibility testing (pDST) for diagnosing drug-resistant tuberculosis (DR-TB). Targeted next-generation sequencing (tNGS) using Oxford Nanopore Technolo...
Multi-site microbiomes' response to chronic obstructive pulmonary disease [0.03%]
多灶性微生物组对慢性阻塞性肺疾病的变化响应
Mingxuan Liu,Wei Zhang,Jing Zhang et al.
Mingxuan Liu et al.
This study aimed to evaluate changes in the oral, nasal, pulmonary, and gut microbiota in patients with chronic obstructive pulmonary disease (COPD) and to explore their interrelationships compared with the healthy group. This study include...
Repurposing azole antifungals as rapid bactericidal, membrane-disruptive therapeutics against Clostridioides difficile [0.03%]
将唑类抗真菌药物再利用为针对艰难梭状芽孢杆菌的快速杀菌和膜破坏疗法
Ahmed A Abouelkhair,Nader S Abutaleb,Brice J Stolz et al.
Ahmed A Abouelkhair et al.
Clostridioides difficile is a leading cause of healthcare-associated infections and remains an urgent global public health concern. Current FDA-approved therapies for C. difficile infection (CDI) are limited and are frequently associated wi...
Multicenter evaluation of a single-device dengue antibody/antigen rapid test for simultaneous detection of NS1, IgM, and IgG [0.03%]
一项登革病毒NS1、IgM和IgG单一检测装置的多中心评估研究报告
Zhihai Zhao,Mettingal Ramakrishnan Shincy,Lay Sin Teoh et al.
Zhihai Zhao et al.
Dengue is a major global health burden in tropical and subtropical regions, where timely diagnosis is crucial for clinical management and outbreak control. Although rapid diagnostic tests (RDTs) are widely used at the point of care, their p...
Genomic insights and biotechnological potential of a saline soil fungus Aspergillus tubingensis FF14 for xanthophyll biosynthesis [0.03%]
芽枝霉属盐生土壤真菌FF14的基因组学见解及其虾青素生物合成的生物技术潜力
Weronika Śliżewska,Katarzyna Struszczyk-Świta,Joanna Oracz et al.
Weronika Śliżewska et al.
Microbial pigment production is often a physiological response to environmental stress, including salinity, oxidative stress, and nutrient limitation. In this study, we investigated Aspergillus tubingensis FF14, a filamentous fungus isolate...
A CRISPR interference system for tunable gene expression integrated with a promoter library for Eubacterium callanderi KIST612, an acetogen of functional diversity and versatility [0.03%]
一种CRISPR干扰系统可调基因表达与多功能乙酸ogens的启动子库集成：Eubacterium callanderi KIST612为例
Byeongchan Kang,Ji-Yeon Kim,Soyoung Oh et al.
Byeongchan Kang et al.
Acetogens are key biocatalysts for carbon-neutral biorefineries, yet their metabolic engineering is limited by the lack of tunable transcriptional regulation systems. Here, we developed a synthetic promoter library for Eubacterium callander...
Comparative performance of L1- and E6/E7-targeted HPV genotyping assays based on a unified MeltArray platform [0.03%]
基于统一的MeltArray平台的L1和E6/E7靶向人乳头瘤病毒分型检测试剂盒的比较性能分析
Yuli Liu,Huihui Qu,Feng Zhang et al.
Yuli Liu et al.
Human papillomavirus (HPV) molecular testing is central to cervical cancer screening. Commercial assays commonly target either the L1 gene or the E6/E7 oncogenes, yet comparative performance data under standardized conditions remain limited...
Metagenomic profiling of bacterial (16S) and fungal (ITS) communities on d'Anjou pears during long-term controlled-atmosphere storage [0.03%]
用于长期气调贮藏的d'Anjou梨中细菌(16S)和真菌(ITS)群落的元基因组分析
Rawane Raad,Amy Mann,Amrit Pal et al.
Rawane Raad et al.
D'Anjou pears are routinely stored for up to nine months under controlled-atmosphere (CA) conditions to meet market demands. While this practice maintains fruit quality, limited information exists on pears' natural microbiota throughout sto...