Facile generation of Hermes insertion mutants in prototrophic Candida glabrata for use in nutrient-limited environments [0.03%]
一种在营养限制环境中使用的丙酮化假丝酵母Hermes插入突变体的简便生成方法
Anna M Zaeske,Abigail A Harrington,Timothy J Nickels et al.
Anna M Zaeske et al.
Transposon mutagenesis coupled with deep sequencing (Tn-seq) is currently being deployed in microbial eukaryotes, including the opportunistic yeast pathogen Candida glabrata, for functional genomics research. This method depends on the gene...
Small non-coding RNA fen36: a novel positive regulator of biofilm formation and swarming motility in Bacillus amyloliquefaciens [0.03%]
枯草芽孢杆菌中小分子非编码RNA fen36：一个新的生物被膜形成及群体移动的正调控因子
Hedong Lu,Chengxin Jiang,Yi Liu et al.
Hedong Lu et al.
Biofilm formation is a critical developmental process for the survival of Bacillus, its environmental adaptation, and host colonization. This study investigated the regulatory function of the novel small non-coding RNA (sRNA) fen36 in biofi...
Association of gut microbiota and inflammatory markers with enteral nutrition intolerance in patients with early-stage moderate-to-severe intracerebral hemorrhage [0.03%]
肠道微生物群和炎症标志物与早期中重度脑出血患者肠内营养耐受性的关联分析
Haixiao Jiang,Hengzhu Zhang,Xuyuan Ding et al.
Haixiao Jiang et al.
Enteral nutrition intolerance (ENI) is a common and challenging complication in patients with moderate-to-severe intracerebral hemorrhage (msICH). Emerging evidence suggests that gut microbiota is vital for host immune regulation and nutrie...
Beyond Mueller-Hinton agar: comparative evaluation of agar media for antibiotic susceptibility testing and implications for resource-limited laboratory settings [0.03%]
穆里尔-霍顿琼脂之外：抗生素敏感性试验琼脂培养基的比较评价及对资源匮乏实验室的影响
Abraham Goodness Ogofure,Ezekiel Green,Etinosa Ogbomoede Igbinosa
Abraham Goodness Ogofure
This study conducted a proof-of-concept risk assessment to compare the performance of available culture media with Mueller-Hinton agar (MHA) as the reference standard in antimicrobial susceptibility testing (AST) in resource-limited laborat...
Adaptive colistin resistance dynamics in mcr-9-positive and -negative Enterobacterales following low-level colistin exposure [0.03%]
暴露于低水平多粘菌素后mcr-9阳性及阴性肠杆科细菌的适应性多粘菌素耐药动态变化
Eva Smelikova,Marie Brajerova,Jan Tkadlec et al.
Eva Smelikova et al.
The mcr-9 gene has been reported across different sources and was recognized as a potential contributor to increased minimum inhibitory concentrations after colistin exposure. This study aimed to determine the prevalence of intestinal carri...
Clustering of inverted triplications in centromeric and subtelomeric chromosomal regions of Aspergillus flavus [0.03%]
曲霉属黄曲霉染色体着丝粒和端粒亚区倒位三联体的聚集效应
Alexie Woods,Amna Malik,Rose Ludecke et al.
Alexie Woods et al.
The formation of inverted repeats frequently initiates rearrangements associated with gene amplification and disease states. Among these rearrangements are inverted triplications (TRP/INVs). We have used the filamentous fungus Aspergillus f...
OmpK36 deficiency and inducible AmpC β-lactamase synergistically drive imipenem resistance in Klebsiella aerogenes [0.03%]
OmpK36缺乏和可诱导的AmpCβ-内酰胺酶协同驱动产气肠杆菌对亚胺培南的耐药性
Shumi Shang,Liyang Chen,Xiaosi Li et al.
Shumi Shang et al.
This study systematically elucidates how ST88-KL186 Klebsiella aerogenes evolved carbapenem resistance through a dual synergistic mechanism involving porin deficiency and inducible AmpC β-lactamase, providing a mechanistic explanation for ...
First complete genome of a fowlpox virus isolated in Bangladesh reveals Asian lineage and clade A1 [0.03%]
来自孟加拉国的第一份鸡 pox 病毒基因组揭示了亚洲谱系和A1亚群
Anandha Mozumder,Roni Mia,Anupam Das et al.
Anandha Mozumder et al.
Fowlpox virus (FPV) is an economically important avian pathogen that continues to cause recurrent outbreaks in poultry worldwide, including Bangladesh, despite routine vaccination. This study aimed to isolate, sequence, and characterize the...
Community structure and methylation of microbes in an artificially forced sediment core [0.03%]
人工操控的沉积物微生物群落结构及甲基化特征研究
Rui Zhao,Jennifer F Biddle
Rui Zhao
Epigenetic modifications, such as DNA methylation, may be used in prokaryotes for the adaptation of microbes to external environmental changes. In this study, we examined the microbial community structure, recovered the genomes of the domin...
Characterization of antimicrobial resistance and virulence traits of clinical Pseudomonas mosselii isolates with reduced meropenem susceptibility and preserved imipenem susceptibility [0.03%]
临床Pseudomonas mosselii分离株的抗菌药物耐药性及毒力特征表征（美罗培南低敏感和亚胺培南保持敏感）
Kaiqi Zeng,Lan Ma,Rong Zhang et al.
Kaiqi Zeng et al.
Pseudomonas mosselii is an environmental bacterium with increasing reports of pathogenic potential. Although carbapenems are considered highly effective against this species, emerging resistance presents a potential therapeutic concern. In ...