Multi-omics profiling of gut-serum axis dynamics in gestational sows with different reproductive performance [0.03%]
不同繁殖性能妊娠母猪肠道-血液多组学特征及机制研究
Sijiao Ran,Shiting Fu,Tianci Dai et al.
Sijiao Ran et al.
Sustainable swine production hinges on optimizing sow reproductive efficiency, yet mechanisms driving healthy litter size and weak piglet rates remain unclear. This study categorized sows into high (group H) and low (group L) healthy litter...
Gut microbial culturomics identifies autism-associated Shigella and reveals species-level remodeling during fecal microbiota transplantation [0.03%]
肠道微生物培养组学鉴定自闭症相关痢疾志贺菌并在粪便菌群移植过程中揭示物种水平的重塑作用
Bin Chen,Zhenzhen Su,Yuqing Sun et al.
Bin Chen et al.
Autism spectrum disorder (ASD) has been repeatedly linked to gut microbiota alterations, yet mechanistic insight remains limited by the scarcity of ASD-specific cultured isolates. Here, we performed large-scale gut microbial culturomics on ...
Getah virus non-structural protein 2 inhibits type I interferon production by preventing K63-linked polyubiquitination of IKKε and causing widespread cellular shutoff [0.03%]
盖塔病毒非结构蛋白2通过防止IKKε的K63连接多泛素化而抑制I型干扰素产生并导致广泛的细胞关闭效应
Min Zhao,Likai Ji,Yi Zhao et al.
Min Zhao et al.
Getah virus (GETV) is an emerging mosquito-borne alphavirus that poses a growing threat to animal and public health. However, the molecular mechanisms underlying its pathogenesis and immune evasion remain poorly defined. This study demonstr...
Targeted sequence capture of coxsackievirus A6 using nanopore sequencing directly from clinical specimens [0.03%]
基于临床标本的纳米孔测序捕获直接捕获CVA6病毒序列
Ziqi Lin,Fenglan He,Han Mo et al.
Ziqi Lin et al.
Coxsackievirus A6 (CVA6) has emerged as a predominant causative agent of hand, foot, and mouth disease worldwide. Efficient genomic surveillance is crucial for understanding its evolution and spread. Nanopore sequencing presents a promising...
The novel antifungal agent NPD2560 perturbs the Rho1-centered signaling network to induce a cell wall integrity response [0.03%]
新型抗真菌药物NPD2560通过干扰Rho1信号网络诱发细胞壁应答反应
Wei Liu,Sekiguchi Hiroki,Sheena C Li et al.
Wei Liu et al.
Fungal pathogens pose an increasing threat to human health. The limited diversity of antifungal drug classes and the rapid emergence of resistance highlight the urgent need for the identification and development of agents with novel mechani...
Age-driven shifts of the camel gut microbiome and resistome in extensively reared dromedary camels [0.03%]
年龄驱动的单峰骆驼肠道微生物组和耐药组的变化——基于广泛饲养环境下的研究
Wenjing Wang,Yitao Li,Yaqian Liang et al.
Wenjing Wang et al.
Camels are uniquely adapted to arid environments and are commonly raised in extensive grazing systems. The composition of their gut microbiome and antimicrobial resistance genes (ARGs) is expected to change with host development, but age-re...
Evaluating myxovirus resistance protein A-based rapid testing combined with pathogen sequencing for arboviral and incidental viral infection surveillance in Senegal [0.03%]
评估结合病原体测序的合胞病毒抗性蛋白A快速检测在塞内加尔监测虫媒病毒感染及意外病毒感染中的应用
Mouhamed Kane,Serge Freddy Moukaha Doukanda,Safietou Sankhé et al.
Mouhamed Kane et al.
Accurate differentiation between viral and bacterial infections remains challenging in resource-limited, arbovirus-endemic settings, leading to antibiotic misuse and diagnostic uncertainty. Myxovirus resistance protein A (MxA), an interfero...
Benchmarking next- versus third-generation sequencing in metagenomics: performance metrics and diagnostic efficacy [0.03%]
下一代测序与第三代测序技术在元基因组学研究中的性能比较及诊断价值评估
Jian Hu,Hua Zhang,Hui Miao et al.
Jian Hu et al.
This study aimed to compare the analytical characteristics and diagnostic performance of short-read next-generation sequencing (NGS) and long-read third-generation sequencing (TGS) for metagenomic pathogen detection, using defined mock comm...
Pneumococcal colonization in pediatric patients undergoing hematopoietic cell transplantation [0.03%]
造血干细胞移植儿科患者的肺炎链球菌定植状况
Liset Olarte,Jennifer E Schuster,Ibrahim Ahmed et al.
Liset Olarte et al.
Despite the increased risk of invasive pneumococcal disease among pediatric hematopoietic cell transplant (HCT) recipients, pneumococcal colonization has not been evaluated in this population. We prospectively assessed longitudinal pneumoco...
Development of a fluorescent reporter strain to facilitate studies of Borrelia burgdorferi pathogenesis [0.03%]
用于促进伯氏疏螺旋体发病机制研究的荧光报告菌株的开发
Annalisa B Huckaby,Maria de la Paz Gutierrez,Ching Wooen Sze et al.
Annalisa B Huckaby et al.
Lyme disease is a tick-borne disease caused by spirochetes of the Borrelia burgdorferi sensu lato complex. Murine models of B. burgdorferi infection allows for the assessment of bacterial dissemination and presence through culture of infect...