Molecular characteristics and analysis of drug resistance-virulence correlation of carbapenem-resistant Klebsiella pneumoniae in northern Henan region [0.03%]
河南省北部地区产碳青霉烯类耐药肠杆菌科分子特征及耐药与毒力相关性分析
Min Li,Guofang Li,Zijiang Jia et al.
Min Li et al.
Klebsiella pneumoniae, particularly carbapenem-resistant Klebsiella pneumoniae (CRKP), has emerged as a pressing threat to global public health. Its intrinsic multidrug resistance and hypervirulence collectively pose a dual burden to clinic...
Species-specific glucose mineralization in artificial soil: insights from Bacillus subtilis and Streptomyces cinnamoneus mono- and co-cultures [0.03%]
芽孢杆菌和链霉菌单培养及共培养在模拟土壤中的糖矿化特异性研究
Kanade Fujiwara,Tomoyuki Makino,Toru Hamamoto
Kanade Fujiwara
Soil microbes play a critical role in carbon (C) cycling, yet assessing the direct impact of individual microbes and their interactions on C mineralization remains poorly understood due to confounding effects under fluctuated physicochemica...
Distinct and shared impacts of virulence plasmids on the phenotype and transcriptome in convergent carbapenem-resistant and hypervirulent Klebsiella pneumoniae [0.03%]
碳青霉烯耐药和高毒力肺炎克雷伯菌中不同与共有的毒力质粒对表型及转录组的影响
Mingju Hao,Xiaodi Cui,Liya Feng et al.
Mingju Hao et al.
The global rise of convergent carbapenem-resistant and hypervirulent Klebsiella pneumoniae (CR-hvKp) represents a major clinical challenge, yet the role of virulence plasmids (pVirs) in shaping bacterial physiology and pathogenicity remains...
Volatile organic compounds associated with red-stripe pathogens inhibit mycelial growth of Morchella sextelata by disrupting membrane integrity and inducing oxidative stress [0.03%]
与红斑病原体相关的挥发性有机化合物通过破坏菌丝膜完整性和诱导氧化应激抑制Morchella sextelata菌丝生长
Xuetai Zhu,Yongxiang Dang,Qi Yang et al.
Xuetai Zhu et al.
The commercial cultivation of Morchella sextelata is severely threatened by red-stripe disease, caused by the pathogenic bacteria, with Bacillus subtilis M-5 and Pseudomonas chlororaphis subsp. aureofaciens M-B being among the causative age...
Carbapenem resistance mediated by blaNDM-13 in a highly drug-resistant Salmonella Stanley ST29 strain in China [0.03%]
中国ST29型多重耐药沙门氏菌Stanley株中由bla NDM-13介导的碳青霉烯类耐药性
Juanjuan Zhou,Junmei Yang,Ke Li et al.
Juanjuan Zhou et al.
The rise of carbapenem-resistant Enterobacterales presents a substantial global public health challenge. While carbapenem-resistant Salmonella is rarely reported in clinical settings, this study characterizes a carbapenem resistance mediate...
Autophagy modulation by OmpA-targeted lead compounds restores autophagic flux, reduces biofilm, and enhances immune response in Acinetobacter baumannii-infected pulmonary cells [0.03%]
针对OmpA的先导化合物通过调节自噬恢复细胞内自噬流，减少生物膜并增强免疫应答以对抗肺细胞中的鲍曼不动杆菌感染
Saroj Sharma,Vishvanath Tiwari
Saroj Sharma
Acinetobacter baumannii is an opportunistic pathogen known for causing severe nosocomial infections. Autophagy, a key host defense mechanism against invading pathogens, is modulated by the virulence factor OmpA. OmpA is also responsible for...
CYP51C Y319H and H349R substitutions cannot confer azole resistance in Aspergillus flavus NRRL 3357-5 [0.03%]
阿夫拉门青霉菌NRRL 3357-5中CYP51C的Y319H和H349R替代不能赋予其唑类抗性
Ya Bin Zhou,Alexey A Grum-Grzhimaylo,Martin Meijer et al.
Ya Bin Zhou et al.
Azole antifungals inhibit the cytochrome P450-dependent lanosterol 14-α-demethylase (CYP51), an essential enzyme in the ergosterol biosynthetic pathway. While azole resistance mechanisms are well established in Aspergillus fumigatus, the m...
Efficacy of a small-volume blood culture diversion device across three wards: a 6-month retrospective review [0.03%]
一种小体积血培养分流装置在三个病房中的有效性的六月回顾式研究
Hallie H Dolin,Alyssa M Krupp,Amrita R John et al.
Hallie H Dolin et al.
Blood culture contamination (BCC) is a challenging issue that can negatively impact patients and healthcare costs. The Clinical and Laboratory Standards Institute (CLSI) historically encouraged a BCC rate of
Exploring the native pulp and paper sludge microbiome to inspire new biotechnologies for waste minimization [0.03%]
探索制浆造纸污泥土著微生物组以启发减废生物技术新应用
Pakinee Thianheng,Kurt Louis Schroeter,Johan Larsbrink et al.
Pakinee Thianheng et al.
Thousands of metric tonnes of diverse sludge wastes are generated annually in the pulp and paper industry. Due to a high moisture content and an abundance of inorganic material, many types of sludge are hard to recycle and instead accumulat...
The mycobacterial nucleoid-associated protein NapM exhibits stress-induced septal localization and modulates cell envelope gene expression [0.03%]
结核分枝杆菌染色体结合蛋白NapM在胁迫下的细胞分裂环定位及其对细胞壁相关基因表达的调控作用
Kornel Milcarz,Joanna Hołówka,Jakub Pawełczyk et al.
Kornel Milcarz et al.
The bacterial chromosome is organized in a hierarchical and dynamic manner to facilitate essential DNA transactions. Nucleoid-associated proteins (NAPs) are abundant, small-scale chromosomal organizers that also play important roles in main...