Blockade of IL-1R signaling diminishes Paneth cell depletion and Toxoplasma gondii induced ileitis in mice [0.03%]
白细胞介素-1受体拮抗剂通过减少沙门菌诱导的潘氏细胞凋亡抑制小鼠空肠炎性损伤
Bérengère Villeret,Léa Brault,Aurélie Couturier-Maillard et al.
Bérengère Villeret et al.
Interleukin 1 is a critical inflammatory mediator and involved in host defense to several pathogens. Oral T. gondii infection causes lethal ileitis in C57BL/6 (BL6) mice and serves to investigate the mechanisms of acute intestinal inflammat...
Regulatory T cells vs Th17: differentiation of Th17 versus Treg, are the mutually exclusive? [0.03%]
调节性T细胞vs Th17：Th17与Treg的分化是相互排斥的吗？
Song Guo Zheng
Song Guo Zheng
Naive CD4(+) cells differentiate into T helper (Th1, Th2, Th9, Th17) and regulatory T (Treg) cells to execute their immunologic function. Whereas TGF-β suppresses Th1 and Th2 cell differentiation, this cytokine promotes Th9, Th17 and Foxp3...
Socorro Miranda-Hernandez,Alan G Baxter
Socorro Miranda-Hernandez
Multiple Sclerosis (MS) is an autoimmune disease in which Central Nervous System (CNS) lesions result from perivascular immune cell infiltration associated with damage to myelin, oligodendrocytes and neurons. CNS autoimmunity and its regula...
Epigenetic regulation of the TRAIL/Apo2L apoptotic pathway by histone deacetylase inhibitors: an attractive approach to bypass melanoma immunotherapy resistance [0.03%]
组蛋白去乙酰化酶抑制剂的表观遗传调控：一种有吸引力的绕过免疫疗法耐药性的方法
Ali R Jazirehi,Dylan Arle
Ali R Jazirehi
TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) is a major cytotoxic mechanism employed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells to eradicate malignant cells. TRAIL/Apo2L interacts with its cognate receptors locate...
Meghan M Delmastro-Greenwood,Jon D Piganelli
Meghan M Delmastro-Greenwood
The breakdown of nutrients into the critical energy source ATP is the general purpose of cellular metabolism and is essential for sustaining life. Similarly, the immune system is composed of different cell subsets that are indispensable for...
Monique C Trengove,Alister C Ward
Monique C Trengove
Cytokine and growth factor signaling mediates essential roles in the differentiation, proliferation, survival and function of a number of cell lineages. This is achieved via specific receptors located on the surface of target cells, with li...
Helen Martin,Christian Taube
Helen Martin
Diseases like asthma have dramatically increased in the last decades. The reasons for the rising prevalence are still controversially discussed. Besides the genetic predisposition a number of different causes are thought to affect the incre...
Differential microRNA epression in asthma and the role of miR-1248 in regulation of IL-5 [0.03%]
哮喘的差异性微小核糖核酸表达及miR-1248对IL-5的调节作用
Ronaldo Paolo L Panganiban,Mark H Pinkerton,Saumya Y Maru et al.
Ronaldo Paolo L Panganiban et al.
Asthma is a chronic inflammatory disease that can be difficult to manage due to a lack of diagnostic biomarkers and an incomplete understanding of the molecular pathogenesis. MicroRNAs (miRNAs) are small, single-stranded, non-coding RNAs wi...
Giuseppe Cappellano,Elisabetta Orilieri,Abiy D Woldetsadik et al.
Giuseppe Cappellano et al.
An overview of the current literature is showing that autoantibodies (AutoAbs) against cytokines are produced in several pathological conditions, including autoimmune diseases, but can also be detected in healthy individuals. In autoimmune ...
The role of ubiquitin ligases in the control of organ specific autoimmunity [0.03%]
泛素连接酶在器官特异性自身免疫调控中的作用
Gerard F Hoyne
Gerard F Hoyne
Diabetes mellitus is characterized by chronic hyperglycemia caused by a deficiency in insulin action, insulin secretion or both. Type 1 diabetes is classified as the destruction of beta cells leading to a deficiency in insulin production. T...