Cell-free DNA fragmentomics as a non-invasive tool for predicting pathologic response in colorectal cancer [0.03%]
无创预测结直肠癌病理反应的细胞游离DNA片段组学技术
Wenshi Hu,Guoyan Li,Wanyu Dong et al.
Wenshi Hu et al.
Despite advances in screening and therapy, colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, underscoring the need for early detection and for predicting treatment efficacy. This review highlights circul...
Granzyme B-producing B cells: a bidirectional relationship with breast cancer cells and implications for immunotherapy [0.03%]
产生颗粒酶B的B细胞与乳腺癌细胞的双向关系及其对免疫治疗的意义
Hosein Hakimi,Fereshteh Mehdipour,Morteza Samadi et al.
Hosein Hakimi et al.
Granzyme B (GrB)-producing B cells have dual roles in tumor immunity, either killing tumor cells or suppressing antitumor responses by eliminating effector T cells. In this study, we aimed to investigate how breast cancer cells influence Gr...
Cyclophosphamide modulates Wnt3a/β-catenin signaling in MRL/lpr mice with lupus nephritis [0.03%]
环磷酰胺通过调节Wnt3a/β-连环蛋白信号途径治疗狼疮性肾炎小鼠模型(MRL/lpr小鼠)
Shuhong Zhou,Liuna Liang,Kai Zhang et al.
Shuhong Zhou et al.
This study was carried out to analyze the time-dependent changes of Wnt3a/β-catenin signaling during lupus nephritis (LN). At the age of 5 weeks, 30 female MRL/lpr mice and C57BL/6 (C57) mice were randomly grouped. Moreover, 12 females MRL...
DPT has potential to be a prognostic biomarker and its correlation with immune infiltrates in prostate cancer [0.03%]
DPT具有作为预后生物标志物的潜力及其与前列腺癌免疫浸润的相关性
Jieyu Jin,Junchao Feng,Tong Zhou et al.
Jieyu Jin et al.
Background: Prostate cancer (PRAD) poses a significant threat to male health. The tumor microenvironment (TME) plays a crucial role in its development process, yet the regulatory significance of specific extracellular mat...
Cell-free DNA fragmentomics: a universal framework for early cancer detection and monitoring [0.03%]
无细胞DNA片段组学：早期癌症检测和监测的通用框架
Wanyu Dong,Wenshi Hu,Yaojuan Lu et al.
Wanyu Dong et al.
Cell-free DNA (cfDNA) fragmentomics has emerged as a powerful and noninvasive approach for cancer detection, characterization, and monitoring. By analyzing genome-wide fragmentation patterns - including fragment length distributions, end mo...
The immunomodulatory role of seminal plasma in endometrial receptivity and embryo implantation [0.03%]
精浆在子宫内膜接受性及胚胎着床中的免疫调节作用
Zahra Kanannejad,Nassim Kheshtchin,Hesamedin Nabavizadeh
Zahra Kanannejad
Successful implantation and pregnancy rely on complex interactions between the embryo and the maternal reproductive tract. Seminal plasma components, including proteins, cytokines, and growth factors, are pivotal in enhancing endometrial re...
Synergic effect of combined melatonin and tofacitinib on ameliorating dextran sulfate sodium-induced colitis in rat---role of JAKs/STAT, cell-stress signaling, and inflammatory-immune reaction [0.03%]
褪黑素与托法替尼联合抗炎机制研究：协同抑制Jak-Stat信号、细胞应激反应及免疫炎症反应抗氧化作用对抗去氧胆酸诱导的小鼠肠道炎症的影响
Chia-Lo Chang,Chih-Hung Chen,Yi-Ling Chen et al.
Chia-Lo Chang et al.
Background: This study investigated whether the combined treatment of melatonin and tofacitinib offers enhanced protection against dextran sulfate sodium-induced acute colitis (AC) in rats. Using CCD-18Co fibroblasts and ...
Identification and analysis of immune aging related biomarkers in cartilage and meniscus tissues of osteoarthritis [0.03%]
关节炎软骨和半月板组织中与免疫衰老相关的生物标志物的鉴定与分析
Zhian Chen,Mingjun Li,Yujiao Feng et al.
Zhian Chen et al.
This study aimed to investigate the relationship between immunosenescence and osteoarthritis (OA) and analyze its potential clinical implications. Thus, we conducted transcriptome sequencing by collecting clinical meniscus (Aging_meniscus:C...
Development of a monoclonal antibody against a synthetic peptide of Buthotus saulcyi scorpion venom: a novel diagnostic and neutralizing tool [0.03%]
一种全新的诊断和中和工具：Buthoscorpius saucy毒液合成肽单克隆抗体的开发
Jamil Zargan,Hossein Delavari Noghabi,Mohammad Sadegh Odehzadeh et al.
Jamil Zargan et al.
Background: Hybridoma technology is an essential method used to produce monoclonal antibodies, providing equal specificity and scalability for biomedical applications. This methodology utilizes a hybridoma formation proce...
IGLL5 has potential to be a prognostic biomarker and its correlation with immune infiltrates in breast cancer [0.03%]
IGLL5有潜力成为乳腺癌预后生物标志物及其与免疫浸润的相关性研究
Junchao Feng,Yuhan Hou,Chang Liu et al.
Junchao Feng et al.
Background: The tumor microenvironment (TME) of breast cancer (BRCA) influences disease progression through dynamic interactions between immunity and stroma, but its key regulatory molecules and prognostic value remain to...