Comparison of allergen types and complete blood count in pediatric allergic rhinitis [0.03%]
儿童变应性鼻炎患者致敏类型和血常规的对照研究
Li Liu,Xiangqian Qiu,Shengli Gao et al.
Li Liu et al.
Background: Allergic rhinitis (AR) is a highly prevalent immunoglobulin E (IgE)-mediated disease that significantly impacts quality of life. While hematological parameters (complete blood count [CBC]) are linked to inflam...
Targeting cannabinoid receptor 1 for multiple sclerosis: molecular docking and dynamic insights of berberine and curcumin as potential therapeutic agents [0.03%]
靶向大麻素受体1治疗多发性硬化症：作为潜在治疗剂的小檗碱和姜黄素的分子对接及动态见解
Jehan Alrahimi
Jehan Alrahimi
Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system characterized by demyelination, inflammation, and progressive neurodegeneration. Cannabinoid receptor 1 (CB1) plays a role in neuroprotection and modulat...
A review of core immuno-inflammatory mechanisms and key regulatory targets in psoriasis [0.03%]
银屑病核心免疫炎症机制及关键调节靶点研究进展
Wenli Zhou,Zhaoyu Li,Xuehai Liu et al.
Wenli Zhou et al.
Psoriasis is a chronic immune-mediated inflammatory skin disease caused by dysregulated interaction between innate and adaptive immune cells. Of note, the IL-23/Th17 axiom is new central circuit amongst known pathways, while TNF-alpha, IL-1...
Cancer-associated mutational patterns reshape miRNA regulatory regions and potentially disrupt miRNA-gene interactions [0.03%]
癌症相关突变模式重塑miRNA调控区域并可能破坏miRNA-基因相互作用
Julia Ran,Xiwen Zhang,Joyce Tang et al.
Julia Ran et al.
MicroRNAs (miRNAs) are key post-transcriptional regulators frequently dysregulated in cancer, yet how somatic mutational patterns influence miRNA regulatory regions remains unclear. In this study, we integrated mutation profiles, transition...
Expression and prognostic significance of CRKL in clear cell renal cell carcinoma [0.03%]
CRKL在透明细胞肾细胞癌中的表达及预后意义
Jinxia Wang,Ye Yang,Xiao Yuan et al.
Jinxia Wang et al.
Clear cell renal cell carcinoma (ccRCC) is an aggressive kidney malignancy with limited prognostic biomarkers. CRKL has been implicated in cancer progression, but its prognostic value and immune associations in ccRCC remain unclear. Using T...
Cardiovascular toxicity induced by immune checkpoint inhibitors: mechanisms linking immune dysregulation and myocardial fibrosis [0.03%]
免疫检查点抑制剂诱导的心血管毒性：免疫紊乱与心肌纤维化之间的机制联系
Di Wang,Bin-Kui Jia,Zhao-Yu Li et al.
Di Wang et al.
Immune checkpoint inhibitors (ICIs) play a key role in cancer immunotherapy, enhancing outcomes for patients with multiple malignancies by blocking the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) and cytotoxic T...
IL-21 expression during sublingual immunotherapy for allergic rhinitis [0.03%]
舌下免疫疗法治疗过敏性鼻炎过程中IL-21的表达
Chunrui Wang,Xiaowei Qin,Li Jiang et al.
Chunrui Wang et al.
Background: Allergic rhinitis (AR) is an inflammatory disorder involving immunoglobulin E (IgE)-mediated immune response. Interleukin (IL)-21 IL-21 can regulate immune cell functions and IgE production. We aimed to explor...
Retrospective analysis of von willebrand factor and microthrombus formation in septic shock: associations with TTP-like syndrome and sepsis-induced coagulopathy [0.03%]
Septic休克中von Willebrand因子和微血栓形成的研究：与TTP样综合征及脓毒症诱导的凝血障碍的关系
Yi Liu,Jinxi Yue,Qingqing Huang et al.
Yi Liu et al.
Objective: Sepsis shock is characterized by endothelial damage and coagulation abnormalities. However, the relationship between von Willebrand factor (vWF), microthrombosis, and various clinical phenotypes such as thrombo...
Preventing sino-nasal polyposis recurrence after functional endoscopic sinus surgery: a multicentric study [0.03%]
内窥镜鼻窦手术后鼻窦乳突炎复发的预防：一项多中心研究
Goran L Omer
Goran L Omer
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) frequently recurs after functional endoscopic sinus surgery (FESS), particularly in patients with eosinophilic inflammation or aspirin-exacerbated respiratory ...
Immune-metabolic crosstalk in rheumatoid arthritis: mediation effects of plasma metabolites on inflammatory cytokines [0.03%]
免疫代谢在类风湿关节炎中的相互作用：血浆代射产物介导炎症细胞因子的作用
Yuting Liang,Yanqiu Zhang,Jieyu Jin et al.
Yuting Liang et al.
Background: Rheumatoid arthritis (RA) is a chronic inflammatory condition defined by synovitis and progressive joint damage. The connection between inflammatory cytokines, molecules, and RA is still poorly understood desp...