Ana Teles,Catharina Thuere,Paul Ojiambo Wafula et al.
Ana Teles et al.
Pregnancy establishment and maintenance represents a challenge for the maternal immune system because it has to be alert against pathogens while tolerating paternal alloantigens expressed in fetal structures. Regulatory T cells (Tregs) are ...
Mimotopic peptide immunotherapy for the treatment of multiple sclerosis, an inflammatory autoimmune disease [0.03%]
用于治疗炎症性自身免疫疾病多发性硬化症的模态肽免疫疗法
Emanuel Calenoff
Emanuel Calenoff
Several lines of evidence suggest that mast cells play a key role in the pathogenesis of Multiple Sclerosis (MS). The contribution of mast cells likely depends upon specific adherence to myelin surface-bound IgE, which triggers degranulatio...
Collaboration of Toll-like and RIG-I-like receptors in human dendritic cells: tRIGgering antiviral innate immune responses [0.03%]
toll样和rig-i样受体在人类树突状细胞中的协作：引发抗病毒先天性免疫反应
Attila Szabo,Eva Rajnavolgyi
Attila Szabo
Dendritic cells (DCs) represent a functionally diverse and flexible population of rare cells with the unique capability of binding, internalizing and detecting various microorganisms and their components. However, the response of DCs to inn...
DNA structures decorated with cathepsin G/secretory leukocyte proteinase inhibitor stimulate IFNI production by plasmacytoid dendritic cells [0.03%]
Cathepsin G/分泌性粒细胞蛋白酶抑制剂修饰的DNA结构通过浆细胞样树突状细胞刺激I型干扰素产生
Joanna Skrzeczynska-Moncznik,Agnieszka Wlodarczyk,Magdalena Banas et al.
Joanna Skrzeczynska-Moncznik et al.
Plasmacytoid dendritic cells (pDCs) and neutrophils are detected in psoriatic skin lesions and implicated in the pathogenesis of psoriasis. pDCs specialize in the production of type I interferon (IFNI), a cytokine that plays an important ro...
The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function [0.03%]
氧化酶活性对于血管粘附蛋白-1（VAP-1）的功能是必不可少的
Thomas Noonan,Susan Lukas,Gregory W Peet et al.
Thomas Noonan et al.
Vascular adhesion protein-1 (VAP-1) has been implicated in the pathogenesis of inflammatory diseases and is suggested to play a role in immune cell trafficking. It is not clear whether this effect is mediated by the oxidase activity or by o...
Shaping the (auto)immune response in the gut: the role of intestinal immune regulation in the prevention of type 1 diabetes [0.03%]
肠道内免疫调节在预防1型糖尿病中的作用：塑造（自）免疫反应
Chiara Sorini,Marika Falcone
Chiara Sorini
The pathogenesis of organ-specific autoimmune diseases such as Type 1 Diabetes (T1D) is regulated by genetic and environmental factors. There is increasing evidence that environmental factors acting at the intestinal level, with a special r...
In the eye of the storm: T cell behavior in the inflammatory microenvironment [0.03%]
风暴之眼：炎症微环境中的T细胞行为
Robert Haas,Federica Marelli-Berg,Claudio Mauro
Robert Haas
Coordinated unfolding of innate and adaptive immunity is key to the development of protective immune responses. This functional integration occurs within the inflamed tissue, a microenvironment enriched with factors released by innate and s...
Dorin-Bogdan Borza,Jun-Jun Zhang,Laurence H Beck Jr et al.
Dorin-Bogdan Borza et al.
Membranous nephropathy (MN) is a major cause of idiopathic nephrotic syndrome in adults, often progressing to end-stage kidney disease. The disease is mediated by IgG antibodies that form subepithelial immune complexes upon binding to antig...
Tumor necrosis factor neutralization combined with chemotherapy enhances Mycobacterium tuberculosis clearance and reduces lung pathology [0.03%]
肿瘤坏死因子中和与化疗联合使用可增强结核杆菌清除并减少肺部病理损伤
Marie-Laure Bourigault,Rachel Vacher,Stéphanie Rose et al.
Marie-Laure Bourigault et al.
Tuberculosis (TB) is a major health problem requiring sustained immunity to inhibit Mycobacterium tuberculosis growth and appropriate antimicrobial therapy to prevent dissemination and drug resistance. Cell-mediated immune responses to M. t...
Potent suppression of arginase 1 expression in murine macrophages by low dose endotoxin [0.03%]
小剂量内毒素强烈抑制小鼠巨噬细胞中精氨酸酶1的表达
Michael J Surace,Liwu Li
Michael J Surace
Macrophages can respond to diverse signals and adopt multiple phenotypes. Although interleukin-4 (IL-4) is shown to potently induce the expression of arginase 1 and contribute to differentiation of macrophages to the anti-inflammatory M2 ph...