Molecular analysis of interleukin-25 exons 1 and 2 and its serum levels in Iranian patients with multiple sclerosis [0.03%]
伊朗多发性硬化症患者IL-25第1和第2外显子的分子分析及其血清水平研究
Mohammad-Reza Javan,Narges Seyfizadeh,Saeed Aslani et al.
Mohammad-Reza Javan et al.
Overexpression of Interleukin-17 (IL-17) family has been shown in a variety of autoimmune diseases. IL-25 (IL-17E), as a member of this family of cytokines, induces the overexpression of IL-13 and impedes Th17/IL-17 responses. In the presen...
Dominant B-cell epitopes from cancer/stem cell antigen SOX2 recognized by serum samples from cancer patients [0.03%]
SOX2蛋白的癌症/干细胞抗原决定簇及其在肿瘤患者血清中的反应谱系分析
Julia Shih,Munira Rahman,Quang T Luong et al.
Julia Shih et al.
Human sex determining region Y-box 2 (SOX2) is an important transcriptional factor involved in the pluripotency and stemness of human embryonic stem cells. SOX2 plays important roles in maintaining cancer stem cell activities of melanoma an...
MicroRNA-570-3p regulates HuR and cytokine expression in airway epithelial cells [0.03%]
microRNA-570-3p通过调节HuR表达调控气道上皮细胞的细胞因子产生
Alanna N Roff,Timothy J Craig,Avery August et al.
Alanna N Roff et al.
Asthma is a chronic lung disease that affects people of all ages and is characterized by high morbidity. The mechanisms of asthma pathogenesis are unclear, and there is a need for development of diagnostic biomarkers and greater understandi...
Urinary tract infections in multiple sclerosis: under-diagnosed and under-treated? A clinical audit at a large University Hospital [0.03%]
多发性硬化合并泌尿系统感染：诊断和治疗不足？大型教学医院临床审计结果
Aneesa Mahadeva,Radu Tanasescu,Bruno Gran
Aneesa Mahadeva
Multiple sclerosis (MS) is a chronic demyelinating immune-mediated disease of the central nervous system. Infections have been implicated in different aspects of the disease such as induction of relapses and possibly, progression. Bladder d...
Aberrant apoptotic machinery confers melanoma dual resistance to BRAF(V600E) inhibitor and immune effector cells: immunosensitization by a histone deacetylase inhibitor [0.03%]
凋亡机制异常使黑色素瘤同时对BRAF(V600E)抑制剂和免疫效应细胞产生抗性：组蛋白去乙酰化酶抑制剂的增敏作用
Ali R Jazirehi,Ramin Nazarian,Antoni Xavier Torres-Collado et al.
Ali R Jazirehi et al.
BRAF(V600E)-inhibitors (BRAFi; e.g., vemurafenib) and modern immune-based therapies such as PD-1/PD-L1 and CTLA-4 checkpoints blockade and adoptive cell transfer (ACT) have significantly improved the care of melanoma patients. Having these ...
Susanna C Fagerholm,Hwee San Lek,Vicky L Morrison
Susanna C Fagerholm
Kindlin-3 is a member of the kindlin family of focal adhesion proteins which bind to integrin beta-chain cytoplasmic domains to regulate integrin function. In contrast to kindlin-1 and kindlin-2 proteins, kindlin-3 is expressed mainly in th...
Tissue plasminogen activator and inflammation: from phenotype to signaling mechanisms [0.03%]
组织型纤溶酶原激活物与炎症：从表型到信号机制
Ling Lin,Kebin Hu
Ling Lin
In disease conditions, inflammatory cells, such as neutrophils, T cells, and monocytes/macrophages, are recruited in response to injury cues and express panoply of proinflammatory genes through a combination of transcription factors. Tissue...
Nafiseh Esmaeil,Marjan Gharagozloo,Abbas Rezaei et al.
Nafiseh Esmaeil et al.
Incidences of sand storms have increased in recent years and there is evidence that these dusts can move across long distances. Sand dusts have different adverse effects on health, but one of the most important of them is pulmonary disease....
Brian A Zabel,Mateusz Kwitniewski,Magdalena Banas et al.
Brian A Zabel et al.
Chemerin is a widely distributed multifunctional secreted protein implicated in immune cell migration, adipogenesis, osteoblastogenesis, angiogenesis, myogenesis, and glucose homeostasis. Chemerin message is regulated by nuclear receptor ag...
Increased levels of interleukins 2 and 17 in the cerebrospinal fluid of patients with idiopathic intracranial hypertension [0.03%]
特发性颅内高压患者脑脊液中IL-2和IL-17水平升高
Laura J Edwards,Basil Sharrack,Azza Ismail et al.
Laura J Edwards et al.
IIH is a condition of raised intracranial pressure of unknown pathogenesis, which is most commonly seen in young overweight women. This study was designed to confirm and extend previous reports by our and other groups showing increased infl...