Advances in the clinical and mechanism research of pollen induced seasonal allergic asthma [0.03%]
花粉诱发的季节性哮喘临床及机制研究进展
Zhi-Juan Xie,Kai Guan,Jia Yin
Zhi-Juan Xie
Seasonal allergic asthma prevalence has been increasing over the last decades and is one of global health concerns now. Pollen is one of the main reasons to cause seasonal allergic asthma and influenced by multiple risk factors. Thunderstor...
Aryan Rafiee Zadeh,Masih Falahatian,Fereshteh Alsahebfosoul
Aryan Rafiee Zadeh
Background: Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system, mostly affecting young adults. Diamine oxidase is an enzyme essential for histamine production. Histamine which is produced mostl...
Pressure pain assessment may predict the outcome of spinal cord stimulation for refractory epilepsy [0.03%]
压力痛评估可能有助于预测难治性癫痫患者脊髓刺激的结果
Li Feng,Li-Hua Fan,Duo-Zhi Wu
Li Feng
It was well-documented that epilepsy and pain arise from an excitation-inhibition imbalance within neuronal networks. A previous meta-analysis of data from clinical trials showed an association between anticonvulsants and specific pain type...
Haiyan Yu,Xiaoling Yuan,Lifeng Liu et al.
Haiyan Yu et al.
Multiple system atrophy is a sporadic progressive degenerative disease which is characterized by multiple central nervous systems involved. So far, there is no effective medicine to cure MSA. The main research direction of treatment include...
Guoping Deng
Guoping Deng
Tumor cells evolve multiple sophisticated mechanisms to escape immune surveillance, one of which is to establish tolerogenic microenvironment by recruiting certain immune suppressive cells such as regulatory T cells (Tregs) and myeloid deri...
Melanocortin-4 receptor in subthalamic nucleus is involved in the modulation of nociception [0.03%]
黑素皮质素受体4在底丘脑核中的镇痛作用研究
Dong-Ji Han,Zhi-Gang He,Hui Yang
Dong-Ji Han
Deep brain stimulation of the subthalamic nucleus (STN-DBS) stimulation produces significant improvement of overall pain related to Parkinson disease; however, the mechanisms underlying analgesic effects of STN-DBS are still unknown. This r...
Induction therapy downregulates the expression of Th17/Tfh cytokines in patients with active lupus nephritis [0.03%]
诱导治疗通过下调Th17/Tfh细胞因子表达减轻狼疮性肾炎患者的肾脏炎症病理损伤
Na Wang,Congcong Gao,Siwan Cui et al.
Na Wang et al.
To determine the potential changes of IL-6, IL-17A and IL-21 levels during induction therapy, and to assess their relationship with disease activity and immunologic features on patients with active lupus nephritis, twenty-eight patients tre...
Effects of allergic stimulation and glucocorticoids on miR-155 in CD4+ T-cells [0.03%]
过敏刺激及糖皮质激素对CD4⁺T细胞中mir-155的影响
Elizabeth Daniel,Alanna Roff,Man-Hsun Hsu et al.
Elizabeth Daniel et al.
Rationale: MicroRNAs (miRNAs) are emerging as important regulators of allergic inflammation and potential therapeutic targets. We sought to identify which miRNAs are expressed in CD4+ T-cells and determine whether allergi...
The effect of icariin on immunity and its potential application [0.03%]
淫羊藿黄酮主要有效成分(icaritin)对免疫系统的影响及其作用机制的研究
Rong Shen,Ju-Hua Wang
Rong Shen
Icariin (ICA) is a major bioactive monomer belonging to flavonoid glycosides attracted from Epimedium, being a classic tonic agent in traditional Chinese medicine. ICA commonly presents multiple effects such as regulating sex hormones, reli...
Wei Zhang,Guo-Ji Yang,Shi-Xian Wu et al.
Wei Zhang et al.
Osteoporosis (OP) and osteoporotic fractures are becoming a serious health care issue in the world. Calcium and vitamin D are the basic treatment for osteoporosis. Nonetheless, they do not effectively reduce the incidences of fracture. Curr...