Pre-vaccination immune signatures of children with inborn errors of immunity associate with COVID-19 vaccine response [0.03%]
Paolo Palma,Elena Emili,Chiara Pighi et al.
Paolo Palma et al.
Individuals with inborn errors of immunity often mount suboptimal responses to vaccination, yet the molecular determinants underlying their variable responses to mRNA vaccines remain poorly defined. The present study aimed to identify basel...
Influenza infection influencing factors and direct economic burden - A study based on hospitalized cases of severe acute respiratory infection (SARI) [0.03%]
Wenjie Xu,Lin Sun,Jinggang Wang et al.
Wenjie Xu et al.
Influenza viruses are one of the key pathogens causing acute respiratory infections in humans, which lead to significant economic burdens. From August 2023 to May 2024, hospitalized SARI cases were recruited from Shouguang People's Hospital...
From discovery through emergency use to the present: Safety evaluation of the COVID-19 mRNA-1273 (Moderna) vaccine [0.03%]
Walter Straus
Walter Straus
The COVID-19 pandemic created an urgent need to develop preventive vaccines to blunt the impact of the greatest global health crisis in a century. Two vaccines, both employing mRNA technology, were developed from bench to bedside in under o...
Estimating the age distribution of disease-causal HPV infection in women with high-grade cervical intraepithelial neoplasia in Denmark, Estonia, Norway, Slovenia, and Sweden: A modeling study [0.03%]
Ugne Sabale,Alhaji Cherif,Stefano Valente et al.
Ugne Sabale et al.
The age distribution of disease-causal human papillomavirus (HPV) infections that lead to high-grade cervical intraepithelial neoplasia (CIN2+) is not well understood in Europe. The objective of this study was to estimate the age at acquisi...
Self-amplifying RNA (saRNA) and circular RNA (circRNA) vaccines: Progress, evidence gaps, and translational pathways for durable and scalable immunization [0.03%]
Ugwu Okechukwu Paul-Chima,Okon Michael Ben,Ogenyi Fabian C et al.
Ugwu Okechukwu Paul-Chima et al.
Self-amplifying RNA (saRNA) and circular RNA (circRNA) are emerging vaccine modalities that extend conventional, non-replicating mRNA platforms. Self-amplifying RNA encodes a replicase that amplifies intracellular RNA templates, enabling hi...
Ivonescimab combined with chemotherapy for the treatment of metastatic cervical cancer: A case report and literature review [0.03%]
Motong Xu,Shuo Qiu,Jie Zhou et al.
Motong Xu et al.
The prognosis for patients with recurrent or metastatic cervical cancer (r/mCC) remains challenging, with a 5-y survival rate of approximately 17%. Although first-line treatment has evolved from traditional single-agent chemotherapy to comb...
LILRB2 inhibition by blocking antibody ES009 reprograms immunosuppressive myeloid cells and enhances T-cell-mediated tumor immunity [0.03%]
Xiaofeng Niu,Chunnian Wang,Yanfen Hu et al.
Xiaofeng Niu et al.
The inhibitory receptor leukocyte immunoglobulin-like receptor B2 (LILRB2), expressed on myeloid cells like monocytes and tumor-resident myeloid cells, sustains an immunosuppressive tumor microenvironment and promotes tumor progression. Pha...
Oncolytic virus therapy for hepatocellular carcinoma: A bibliometric analysis of research landscapes, hotspots, and clinical transformation trends from 2000 to mid-2025 [0.03%]
Fei Yu,Sihan Yin,Jiayu Zhu et al.
Fei Yu et al.
This study aimed to systematically analyze the research status, hotspots, and trends of oncolytic virotherapy (OV) for hepatocellular carcinoma (HCC) from 2000 to mid-2025, scientifically predict future directions, facilitate clinical trans...
Childhood immunization barriers and interventions in low- and middle-income countries: A scoping review of access, delivery systems, and health literacy [0.03%]
Yasmin Fatinah,Marsa Qolbina,Mohammed Alfaqeeh et al.
Yasmin Fatinah et al.
Childhood immunization is among the most effective public health measures for preventing infectious diseases and reducing child mortality, yet coverage in many low- and middle-income countries (LMICs) remains suboptimal due to barriers in a...
Irene Gobe,Thabiso Mogowa,Khutsafalo Kadimo et al.
Irene Gobe et al.
Mumps, though often self-limiting, can cause serious complications such as meningitis, orchitis, infertility, deafness, and seizures. Despite rising cases in Africa, most countries do not vaccinate against mumps. This review compiled availa...