Seunghwan Choi,Joon-Yong An
Seunghwan Choi
The advent of multiomics has ushered in a new era of cancer research characterized by integrated genomic, transcriptomic and proteomic analysis to unravel the complexities of cancer biology and facilitate the discovery of novel biomarkers. ...
Ion mobility spectrometry and ion mobility-mass spectrometry in clinical chemistry [0.03%]
临床化学中的离子迁移谱及离子淌度-质谱技术
Kyle E Lira,Jody C May,John A McLean
Kyle E Lira
Advancements in clinical chemistry have major implications in terms of public health, prompting many clinicians to seek out chemical information to aid in diagnoses and treatments. While mass spectrometry (MS) and hyphenated-MS techniques s...
Danielle M Luettel,Marcia R Terluk,Jaehyeok Roh et al.
Danielle M Luettel et al.
Gaucher disease (GD) is a rare lysosomal disorder characterized by the accumulation of glycosphingolipids in macrophages resulting from glucocerebrosidase (GCase) deficiency. The accumulation of toxic substrates, which causes the hallmark s...
Christina Mousele,David Holden,Sharmilee Gnanapavan
Christina Mousele
Neurofilaments (NFs), major cytoskeletal constituents of neurons, have emerged as universal biomarkers of neuronal injury. Neuroaxonal damage underlies permanent disability in various neurological conditions. It is crucial to accurately qua...
Anastasia Bougea
Anastasia Bougea
Digital biomarker (DB) assessments provide objective measures of daily life tasks and thus hold promise to improve diagnosis and monitoring of Parkinson's disease (PD) patients especially those with advanced stages. Data from DB studies can...
RNA biomarkers in cancer therapeutics: The promise of personalized oncology [0.03%]
癌症治疗中的RNA生物标志物：个性化医学的前景
Hector Katifelis,Maria Gazouli
Hector Katifelis
Cancer therapy is a rapidly evolving and constantly expanding field. Current approaches include surgery, conventional chemotherapy and novel biologic agents as in immunotherapy, that together compose a wide armamentarium. The plethora of ch...
Dalma Horvat,Lucia Agoston-Coldea
Dalma Horvat
The ever-increasing life expectancy of the global population introduces a critical perspective on the impact of aging as an immutable cardiovascular risk factor, particularly manifesting in the alterations observed in the pulmonary artery (...
Eglė Mazgelytė,Dovilė Karčiauskaitė
Eglė Mazgelytė
Cortisol, a stress hormone, plays a crucial role in regulating metabolic, hemodynamic, inflammatory, and behavioral processes. Its secretion is governed by the hypothalamic-pituitary-adrenal axis. However, prolonged activation of this axis ...
Yonca Senem Akdeniz,Seda Özkan
Yonca Senem Akdeniz
Chronic obstructive pulmonary disease (COPD), a global healthcare and socioeconomic burden, is a multifaceted respiratory disorder that results in substantial decline in health status and life quality. Acute exacerbations of the disease con...
Volatile organic compounds in cancer and exhaled breath detection technology [0.03%]
用于癌症检测的挥发性有机化合物及呼出气检测技术
Xinyuan Zhou,Manqing Qi,Mingqi Tang et al.
Xinyuan Zhou et al.
The detection of volatile organic compounds (VOCs) in breath has become a potential method for early cancer screening. Although this approach has attracted increasing attention from the both scientific and medical communities, it has not re...