Anne E Tebo
Anne E Tebo
Idiopathic inflammatory myopathies (IIM), generally referred to as myositis is a heterogeneous group of diseases characterized by muscle inflammation and/or skin involvement, diverse extramuscular manifestations with variable risk for malig...
Lays Adrianne M Trajano-Silva,Simon Ngao Mule,Giuseppe Palmisano
Lays Adrianne M Trajano-Silva
Developing molecular strategies to manipulate gene expression in trypanosomatids is challenging, particularly with respect to the unique gene expression mechanisms adopted by these unicellular parasites, such as polycistronic mRNA transcrip...
Ulvi Kahraman Gürsoy,Meltem Özdemir Kabalak,Mervi Gürsoy
Ulvi Kahraman Gürsoy
Due to technologic advancements, periodontology has witnessed a boost in biomarker research over the past three decades. Indeed, with the aid of omics, our understanding of the healthy periodontium, pathogenesis of periodontal diseases, and...
Berrak Güven,Murat Can
Berrak Güven
Fibrinogen is the primary precursor protein for the fibrin clot, which is the final target of blood clotting. It is also an acute phase reactant that can vary under physiologic and inflammatory conditions. Disorders in fibrinogen concentrat...
Alexandre Raynor,Walid Haouari,Elodie Lebredonchel et al.
Alexandre Raynor et al.
Congenital disorders of glycosylation (CDG) are one of the fastest growing groups of inborn errors of metabolism, comprising over 160 described diseases to this day. CDG are characterized by a dysfunctional glycosylation process, with molec...
Lucia Agoston-Coldea,Andra Negru
Lucia Agoston-Coldea
Cardiac fibrosis, associated with right heart dysfunction, results in significant morbidity and mortality. Stimulated by various cellular and humoral stimuli, cardiac fibroblasts, macrophages, CD4+ and CD8+ T cells, mast and endothelial cel...
Nigel P Murray
Nigel P Murray
Minimal residual disease (MRD) has been defined as a very small numbers of cancer cells that remain in the body after curative treatment. Its presence or absence will ultimately determine prognosis. With the introduction of new technologies...
Martine Paquette,Alexis Baass
Martine Paquette
Familial hypercholesterolemia (FH), a semi-dominant genetic disease affecting more than 25 million people worldwide, is associated with severe hypercholesterolemia and premature atherosclerotic cardiovascular disease. Over the last decade, ...
Maximo J Marin,Xander M R van Wijk,Allison B Chambliss
Maximo J Marin
Sepsis, a dysregulated host immune response to an infectious agent, significantly increases morbidity and mortality for hospitalized patients worldwide. This chapter reviews (1) the basic principles of infectious diseases, pathophysiology a...
Alexander E Berezin,Alexander A Berezin
Alexander E Berezin
Physiologically, extracellular vesicles (EVs) have been implicated as crucial mediators of immune response, cell homeostasis, angiogenesis, cell differentiation and growth, and tissue repair. In heart failure (HF) they may act as regulators...