Johan Lassus,Tuukka Tarvasmäki,Heli Tolppanen
Johan Lassus
Biomarkers are useful for diagnosis, disease monitoring and risk stratification in cardiovascular disease. Cardiogenic shock (CS) is a medical emergency caused by a primary cardiac insult resulting in inadequate cardiac output, hypoperfusio...
Chin-Chuen Lin,Tiao-Lai Huang
Chin-Chuen Lin
Orexin A and B, also known as hypocretin 1 and 2, are excitory neuropeptides synthesized in the perifornical and lateral hypothalamic areas. Following their discovery in 1998, orexins are now known to be involved in feeding, sleep, stress r...
Amitava Dasgupta
Amitava Dasgupta
Biotin (vitamin B7 or vitamin H), a member of vitamin B complex, acts as a cofactor for five biotin-dependent carboxylases, thus playing critical roles in gluconeogenesis, fatty acid synthesis and amino acid catabolism. Although rare inborn...
Carmen M Cabrera
Carmen M Cabrera
Oligoclonal bands (OCBs) in cerebrospinal fluid (CSF) represent an indicator of IgG and IgM immunoglobulins intrathecal synthesis in the central nervous system (CNS). The techniques and detection methods for their determination have evolved...
Alejandro Gugliucci
Alejandro Gugliucci
Dysfunctional visceral fat plays a key role in the initiation and maintenance of chronic inflammation, liver steatosis and subsequent systemic insulin resistance that primes the body for development of metabolic syndrome. These changes, occ...
Gregory S Makowski
Gregory S Makowski
Lennart J van Winden,Huub H van Rossum
Lennart J van Winden
Testosterone is an essential steroid hormone associated with a wide variety of biological processes in humans. In prostate cancer, androgen signaling is an important driver of tumor cell growth. Depletion of gonadal testosterone, achieved b...
Chiara Bellia,Mauro Lombardo,Marco Meloni et al.
Chiara Bellia et al.
Epidemiologic studies have documented an association between diabetes and increased risk of cognitive decline in the elderly. Based on animal model studies, several mechanisms have been proposed to explain such an association, including cen...
Mono/polyclonal free light chains as challenging biomarkers for immunological abnormalities [0.03%]
单克隆/多克隆自由轻链作为免疫异常具有挑战性的生物标志物
Cecilia Napodano,Krizia Pocino,Francesca Gulli et al.
Cecilia Napodano et al.
Free light chain (FLC) kappa (k) and lambda (λ) consist of low molecular weight proteins produced in excess during immunoglobulin synthesis and secreted into the circulation. In patients with normal renal function, over 99% of FLCs are fil...
Lisa Johnson
Lisa Johnson
Diagnosis of chronic gastrointestinal and pancreatic diseases is challenging because patients generally present with nonspecific symptoms, such as abdominal pain and chronic diarrhea, some of which can last for many years. Although stool as...