Gregory S Makowski
Gregory S Makowski
Biochemistry and pathophysiology of the Transient Potential Receptor Vanilloid 6 (TRPV6) calcium channel [0.03%]
瞬时受体电位香草素6（TRPV6）钙通道的生化和病理生理学
Valerie Walker,Geerten W Vuister
Valerie Walker
TRPV6 is a Transient Receptor Potential Vanilloid (TRPV) cation channel with high selectivity for Ca2+ ions. First identified in 1999 in a search for the gene which mediates intestinal Ca2+ absorption, its far more extensive repertoire as a...
Hemophilia A: Emicizumab monitoring and impact on coagulation testing [0.03%]
甲型血友病：emicizumab的监测及其对凝血检测的影响
Michael A Nardi
Michael A Nardi
Hemophilia A is an X-linked recessive bleeding disorder characterized by absent or ineffective coagulation factor VIII, a condition that could result in a severe and potentially life-threatening bleed. Although the current standard of care ...
Arturo Vega-Beyhart,Marta Araujo-Castro,Felicia A Hanzu et al.
Arturo Vega-Beyhart et al.
Cortisol, the main human glucocorticoid, is synthesized from cholesterol in the adrenal cortex and predominantly metabolized by the liver. Interpretation of quantitative results from the analysis of serum, urine and saliva is complicated by...
Reinaldo Marín,Cilia Abad,Deliana Rojas et al.
Reinaldo Marín et al.
Oxidative stress is the result of an imbalance between the formation of reactive oxygen species (ROS) and the levels of enzymatic and non-enzymatic antioxidants. The assessment of biological redox status is performed by the use of oxidative...
Aleks Shin,Shawn Connolly,Kuanysh Kabytaev
Aleks Shin
Diabetes mellitus is the ninth leading cause of mortality worldwide. It is a complex disease that manifests as chronic hyperglycemia. Glucose exposure causes biochemical changes at the proteome level as reflected in accumulation of glycated...
Elif Burcu Aydın,Muhammet Aydın,Mustafa Kemal Sezgintürk
Elif Burcu Aydın
The analysis of salivary biomarkers has gained interest and is advantageous for simple, safe, and non-invasive testing in diagnosis as well as treatment. This chapter explores the importance of saliva biomarkers and summarizes recent advanc...
Gregory S Makowski
Gregory S Makowski
Advances in exosome analysis [0.03%]
外泌体分析的进展
Arnau Pallares-Rusiñol,Mireia Bernuz,Silio Lima Moura et al.
Arnau Pallares-Rusiñol et al.
There is growing demand for novel biomarkers that detect early stage disease as well as monitor clinical management and therapeutic strategies. Exosome analysis could provide the next advance in attaining that goal. Exosomes are membrane en...
Joel Simrén,Anders Elmgren,Kaj Blennow et al.
Joel Simrén et al.
Alzheimer's disease (AD) characterization has progressed from being indexed using clinical symptomatology followed by neuropathological examination at autopsy to in vivo signatures using cerebrospinal fluid (CSF) biomarkers and positron emi...