PA2G4P4 Promotes Glioma Cell Migration and Tumorigenesis through the PTEN/AKT/mTOR Signaling Pathway [0.03%]
PA2G4P4通过PTEN/AKT/mTOR信号通路促进胶质瘤细胞迁移和肿瘤发生
Xiaofeng Hou,ZhengXiong Kou,Hengzhu Zhang
Xiaofeng Hou
Dysregulation of pseudogene expression is closely related to the progression of various cancers, including glioma. Proliferation-associated 2G4 pseudogene 4 (PA2G4P4) could affect cell viability and apoptosis of glioma cells. However, the s...
Anticancer Phytochemical-Based Nanoformulations: Therapeutic Intervention in Cancer Cell Lines [0.03%]
基于抗肿瘤植物化学物质的纳米配方：癌症细胞系治疗干预
Debjyoti Talukdar,Parveen Kumar,Deepak Sharma et al.
Debjyoti Talukdar et al.
Phytochemicals have the potential to treat resistant cancer. They are delivered to the target site via nano-based carriers. Promising results are seen in preclinical and in vitro models, as phytochemical-based nanoformulations have improved...
Seyma Buyucek,Sinem Kantarcioglu Coskun,Binnur Onal et al.
Seyma Buyucek et al.
Receptor tyrosine kinase pathway is frequently searched for cancer causing mutations in tumors. Emerging targeted therapies are gleam of hope for them. Infiltrating urothelial carcinoma can have many morphological aspects according to their...
A Review on Experimentally Proven Medicinal Plants and Their Constituents against Fluoride Toxicity [0.03%]
抗氟毒的药用植物及活性成分研究进展
Sanjib Bhattacharya
Sanjib Bhattacharya
Fluoride toxicity, principally by polluted groundwater, is regarded as a momentous global public health risk, as there is no particular and proven treatment for chronic fluoride toxicity i.e., fluorosis which leads to several serious health...
Recent Developments and Challenges in Molecular-Targeted Therapy of Non-Small-Cell Lung Cancer [0.03%]
非小细胞肺癌分子靶向治疗的新进展和挑战
Suman Rohilla,Mahaveer Singh,Sami I Alzarea et al.
Suman Rohilla et al.
Treatment of lung cancer with conventional therapies, which include radiation, surgery, and chemotherapy results in multiple undesirable adverse or side effects. The major clinical challenge in developing new drug therapies for lung cancer ...
miR-125b-5p Suppresses Leukemia Cell Proliferation by Regulating MCL1 [0.03%]
微小RNA-125b-5p通过调节MCL1抑制白血病细胞增殖
Yan Zhou,Huan Zhu,Jinan Han et al.
Yan Zhou et al.
Leukemia threatens children's health, and leukemia cell proliferation and apoptosis participate in the regulation of leukemia. The current study aims to probe into the miR-125b-5p biological function in regulating leukemia cell proliferatio...
Exploring the Mechanical Perspective of a New Anti-Tumor Agent: Melatonin [0.03%]
从机械论角度探索新的抗肿瘤药物——褪黑素
Suman Rohilla,Mahaveer Singh,Sakshi Priya et al.
Suman Rohilla et al.
Melatonin is a serotonin-derived pineal gland hormone with many biological functions like regulating the sleep-wake cycle, circadian rhythm, menstrual cycle, aging, immunity, and antioxidants. Melatonin synthesis and release are more pronou...
PI3K/Akt/mTOR Pathways Inhibitors with Potential Prospects in Non-Small-Cell Lung Cancer [0.03%]
PI3K/Akt/mTOR 通路抑制剂在非小细胞肺癌中的潜在应用前景
Khalid Saad Alharbi,Mohammad Arshad Javed Shaikh,Waleed Hassan Almalki et al.
Khalid Saad Alharbi et al.
Lung cancer is the leading cause of cancer-related mortality across the globe. The most prevalent pathological form of lung cancer is non-small-cell lung cancer (NSCLC). Elevated stimulation of the PI3K/Akt/mTOR pathway causes a slew of can...
Saptadip Samanta
Saptadip Samanta
Melatonin is primarily synthesized in the pineal gland under the influence of noradrenergic stimulation at night. It regulates the sleep-wake cycle, gonadal activity, redox homeostasis, immune functions, and anticarcinogenic effects at the ...
Promising Action of Cannabinoids on ER Stress-Mediated Neurodegeneration: An In Silico Investigation [0.03%]
大麻素对内质网应激介导的神经退行性变的潜在作用：一项基于计算机的调查
Fathima Hajee Basha,Mohammad Waseem,Hemalatha Srinivasan
Fathima Hajee Basha
Neurodegeneration has been recognized as a clinical episode characterized by neuronal death, including dementia, cognitive impairment and movement disorder. Most of the neurodegenerative deficits, via clinical symptoms, includes common path...