A Review on Experimentally Proven Medicinal Plants and Their Constituents against Fluoride Toxicity [0.03%]
抗氟毒的药用植物及活性成分研究进展
Sanjib Bhattacharya
Sanjib Bhattacharya
Fluoride toxicity, principally by polluted groundwater, is regarded as a momentous global public health risk, as there is no particular and proven treatment for chronic fluoride toxicity i.e., fluorosis which leads to several serious health...
Recent Developments and Challenges in Molecular-Targeted Therapy of Non-Small-Cell Lung Cancer [0.03%]
非小细胞肺癌分子靶向治疗的新进展和挑战
Suman Rohilla,Mahaveer Singh,Sami I Alzarea et al.
Suman Rohilla et al.
Treatment of lung cancer with conventional therapies, which include radiation, surgery, and chemotherapy results in multiple undesirable adverse or side effects. The major clinical challenge in developing new drug therapies for lung cancer ...
miR-125b-5p Suppresses Leukemia Cell Proliferation by Regulating MCL1 [0.03%]
微小RNA-125b-5p通过调节MCL1抑制白血病细胞增殖
Yan Zhou,Huan Zhu,Jinan Han et al.
Yan Zhou et al.
Leukemia threatens children's health, and leukemia cell proliferation and apoptosis participate in the regulation of leukemia. The current study aims to probe into the miR-125b-5p biological function in regulating leukemia cell proliferatio...
Exploring the Mechanical Perspective of a New Anti-Tumor Agent: Melatonin [0.03%]
从机械论角度探索新的抗肿瘤药物——褪黑素
Suman Rohilla,Mahaveer Singh,Sakshi Priya et al.
Suman Rohilla et al.
Melatonin is a serotonin-derived pineal gland hormone with many biological functions like regulating the sleep-wake cycle, circadian rhythm, menstrual cycle, aging, immunity, and antioxidants. Melatonin synthesis and release are more pronou...
PI3K/Akt/mTOR Pathways Inhibitors with Potential Prospects in Non-Small-Cell Lung Cancer [0.03%]
PI3K/Akt/mTOR 通路抑制剂在非小细胞肺癌中的潜在应用前景
Khalid Saad Alharbi,Mohammad Arshad Javed Shaikh,Waleed Hassan Almalki et al.
Khalid Saad Alharbi et al.
Lung cancer is the leading cause of cancer-related mortality across the globe. The most prevalent pathological form of lung cancer is non-small-cell lung cancer (NSCLC). Elevated stimulation of the PI3K/Akt/mTOR pathway causes a slew of can...
Saptadip Samanta
Saptadip Samanta
Melatonin is primarily synthesized in the pineal gland under the influence of noradrenergic stimulation at night. It regulates the sleep-wake cycle, gonadal activity, redox homeostasis, immune functions, and anticarcinogenic effects at the ...
Promising Action of Cannabinoids on ER Stress-Mediated Neurodegeneration: An In Silico Investigation [0.03%]
大麻素对内质网应激介导的神经退行性变的潜在作用：一项基于计算机的调查
Fathima Hajee Basha,Mohammad Waseem,Hemalatha Srinivasan
Fathima Hajee Basha
Neurodegeneration has been recognized as a clinical episode characterized by neuronal death, including dementia, cognitive impairment and movement disorder. Most of the neurodegenerative deficits, via clinical symptoms, includes common path...
Effects of RNA Modification "Writers" of GALNT2 on the Tumor Microenvironment in Cervical Squamous Cell Carcinoma [0.03%]
GALNT2修饰"书写者"对宫颈鳞癌肿瘤微环境的影响
Shizhang Wang,Lin Chen
Shizhang Wang
Cervical squamous cell carcinoma (CESC) is one of the most common causes of cancer-related deaths in women. RNA modification "writers" modulate and alter RNA molecular activity and have been implicated in the origin and development of cance...
miR-210-3p Impairs Pancreatic β-Cell Function by Targeting Dtx1 in Gestational Diabetes Mellitus [0.03%]
miR-210-3p通过靶向Dtx1损害妊娠糖尿病的胰岛β细胞功能
Xiaohui Cao,Bin Lu,Ying Gu et al.
Xiaohui Cao et al.
Gestational diabetes mellitus (GDM), a common complication in pregnancy, could threaten the health of both pregnancies and their offspring. miR-210-3p has been reported that play a crucial role in many diseases. Nevertheless, the molecular ...
Peng Hu,Jinwei Guo,Benhuo Zhao et al.
Peng Hu et al.
Inactivation of hepatic stellate cells (HSCs) slows down liver cirrhosis (LC) advancement. The role of circular RNAs (circRNAs) in LC is largely undiscovered. Here, we clarified the effect of circCHD2 on HSCs. LX-2 cells were stimulated wit...