The Mutational and Transcriptional Landscapes of Speckle-Type POZ Protein (SPOP) and Androgen Receptor (AR) in a Single-Center pT3 Prostatectomy Cohort [0.03%]
单中心pT3前列腺切除队列中SPOP和AR的突变及转录组谱系分布研究
Isil Ezgi Eryilmaz,Berna Aytac Vuruskan,Onur Kaygisiz et al.
Isil Ezgi Eryilmaz et al.
Prostate cancer (PCa) is a heterogeneous disease both clinically and genetically. According to The Cancer Genome Atlas (TCGA), the speckle‑type POZ protein (SPOP) mutant form is one of the significant core subtypes of PCa. However, the pro...
Chemotherapeutic Drugs Endow Gastric Cancer Mesenchymal Stem Cells with Stronger Tumor-Promoting Ability [0.03%]
化疗药物赋予胃癌间充质干细胞更强的促肿瘤能力
Jiaqi Shen,Chao Huang,Linjing Cui et al.
Jiaqi Shen et al.
Gastric cancer (GC) is one of the most aggressive tumors and has a poor prognosis. It has been demonstrated that gastric cancer mesenchymal stem cells (GC-MSCs) can promote the progression, metastasis, and chemoresistance of GC through vari...
Differences between Urban and Rural Environments on Cardiovascular Health: A Systematic Review [0.03%]
城市和农村环境对心血管健康的影响差异：系统综述
Venetia Notara,Stamatia Kokkou,Emanouil Bindakos et al.
Venetia Notara et al.
The effect of the urban vs. rural environment on cardiovascular health is an extremely significant issue, nowadays. Up to date, there is a number of studies revealing that there is environmental impact on the prevalence of cardiovascular di...
Identification of Potential Diagnostic and Prognostic Biomarkers for Gastric Cancer Based on Bioinformatic Analysis [0.03%]
基于生物信息学分析的胃癌潜在诊断和预后生物标志物识别研究
Yecheng Lin,Lei Zhang,Xiaoling Zhang et al.
Yecheng Lin et al.
Gastric cancer (GC) ranks third for cancer-related fatalities worldwide. It is still unclear what causes GC to progress. Using integrated bioinformatics analysis, COL5A2 has been proved to be related to GC development, which may identify th...
Comprehensive Analysis of the Sorafenib-Associated Druggable Targets on Differential Gene Expression and ceRNA Network in Hepatocellular Carcinoma [0.03%]
索拉非尼相关药物作用靶点在肝细胞癌差异表达基因及ceRNA网络中的综合分析
Zhi Fu,Guang Yang,Tiezheng Wang et al.
Zhi Fu et al.
Hepatocellular carcinoma (HCC) is the predominant pathological type of liver cancer. Several therapeutic treatments, including sorafenib and regorafenib, have only modestly improved survival in patients with HCC. The aim of this study was t...
Role of METTL3 in Aerobic Glycolysis of Glioma by Regulating m6A/miR-27b-3p/PDK1 [0.03%]
METTL3通过调节m6A/miR-27b-3p/PDK1调控胶质瘤有氧糖酵解的作用
Cijie Ruan,Yuanda Zhang,Jue Zhou et al.
Cijie Ruan et al.
Methyltransferase like 3 (METTL3) has been reported to be dysregulated in glioma. However, its role in aerobic glycolysis of glioma remains unknown. This study was conducted to explore the molecular mechanism by which METTL3 regulates aerob...
Janus Kinase-Signal Transducer and Activator of Transcription Inhibitors for the Treatment and Management of Cancer [0.03%]
JAK-STAT抑制剂在癌症治疗和管理中的应用
Fahim Anwar Rizwi,Md Abubakar,Eswara Rao Puppala et al.
Fahim Anwar Rizwi et al.
According to the World Health Organization (WHO), cancer is the second-highest cause of mortality worldwide, killing nearly 9.6 million people annually. Despite the advances in diagnosis and treatment during the last couple of decades, it r...
Clinicopathologic Features and Prognostic Significance of Immunohistochemistry and In Situ Hybridization Based Molecular Classification in Gastric Carcinoma [0.03%]
胃癌的临床病理特征及免疫组化和原位杂交分子分型的预后意义
Gizem Issin,İlyas Sayar,Fatih Demir et al.
Gizem Issin et al.
Background/aim: Gastric carcinoma (GC) is a highly heterogeneous disease with many subtypes that have different morphologic and molecular characteristics. In the current study, we analyzed immunohistochemical (IHC) and in...
An Insight into the Salutary Prospect of the Probiotic Microorganisms for the Remediation of Mercury Toxicity [0.03%]
益生菌微生物在汞毒缓解中的应用展望
Sanjib Bhattacharya
Sanjib Bhattacharya
Heavy metal toxicity imposes a potential worldwide threat to environment and humans. Mercury toxicity is regarded as a serious global community health risk, as there is no particular and proven treatment for chronic mercury toxicity. Probio...
METTL14 Promotes Oral Squamous Cell Carcinoma Progression by Regulating the mRNA and m6A Levels of CALD1 [0.03%]
METTL14通过调节CALD1的mRNA和m6A水平促进口腔鳞状细胞癌进展
Ruixue Chen,Suxin Zhang,Hexiang Li et al.
Ruixue Chen et al.
Oral squamous cell carcinoma (OSCC) still threatens people's daily life. METTL14 is a newly discovered methyltransferase that catalyzes m6A methylation. Hence, this research was carried out to investigate the action mechanism of METTL14 in ...