Complex Genomic Rearrangement Patterns in Malignant Pleural Mesothelioma due to Environmental Asbestos Exposure [0.03%]
环境石棉暴露引起的恶性胸膜间皮瘤的复杂基因组重排模式
Tunç Tuncel,Güntülü Ak,Hasan Veysi Güneş et al.
Tunç Tuncel et al.
Malignant pleural mesothelioma (MPM) is a rare type of cancer, and its main risk factor is exposure to asbestos. Accordingly, our knowledge of the genomic structure of an MPM tumor is limited when compared to other cancers. In this study, w...
TFR1-Mediated Iron Metabolism Orchestrates Tumor Ferroptosis and Immunity in Non-Small Cell Lung Cancer [0.03%]
非小细胞肺癌中TFR1介导的铁代谢调控肿瘤铁死亡和免疫反应
Zunqiao Wang,Xingkai Yao,Keping Wang et al.
Zunqiao Wang et al.
This study aimed to investigate the underlying molecular mechanisms of transferrin receptor (TFR1) in non-small cell lung cancer (NSCLC). Histological analysis was performed using hematoxylin-eosin (HE) staining. The number of CD8+ T cell w...
Transcription Factor E2F1 Enhances Hepatocellular Carcinoma Cell Proliferation and Stemness by Activating GINS1 [0.03%]
E2F1通过激活GINS1促进肝癌细胞增殖和干细胞样特性
Xuefeng Ren,Lianqiang Shen,Shan Gao
Xuefeng Ren
Present studies report that high expression of GINS complex subunit 1 (GINS1) is notably pertinent to poor survival for hepatocellular carcinoma (HCC), but it remains unclear how GINS1 affects the progression of HCC. This study aims at inve...
Can the Toxic Heavy Metals Be Beneficial at Trace Levels? Understanding Their Outranged Biological Functions [0.03%]
微量的有毒重金属会有益吗？了解其超范围的生物功能
Sanjib Bhattacharya
Sanjib Bhattacharya
Heavy metal toxicity poses a serious danger to the environment and its inhabitants on a global scale. The harmful heavy metals that are not necessary but are still dangerous, such as lead, arsenic, cadmium, and mercury are frequently linked...
Frequency of Healthy Control Genotype of VDR Gene Polymorphisms in the Saudi Population of the Ha'il Region: A Comparative Study with Worldwide Population [0.03%]
沙特海尔地区VDR基因多态性健康对照组基因型频率的全球人群比较研究
Mahvish Khan,Nashwa Z A Bushara,Manoj Kumar et al.
Mahvish Khan et al.
Genetic polymorphisms in the vitamin D receptor (VDR) may influence the biological effects of vitamin D and increase a person's susceptibility to cancer. Previous studies have shown that different ethnic groups exhibit varying frequencies o...
Comprehensive Investigation of m6A Regulators for Prognosis in Head and Neck Squamous Cell Carcinoma [0.03%]
全面调查m6A调控因子在头颈鳞状细胞癌预后中的作用
Jingning Cheng,Yong Lyu,Ziyan Cheng
Jingning Cheng
The early detection of head and neck squamous cell carcinoma (HNSCC) has an important impact on the clinical prognosis. N6-methyladenosine (m6A) is involved in the post-transcriptional regulation of tumorigenesis and development. In this st...
Whole-Genome Comparative Copy Number Alteration Profiling between Malignant Pleural Mesothelioma and Asbestos-Induced Chronic Pleuritis [0.03%]
恶性胸膜间皮瘤与石棉所致慢性胸膜炎的全基因组拷贝数变异比较研究
Tunç Tuncel,Muzaffer Metintas,A K Güntülü et al.
Tunç Tuncel et al.
Malignant pleural mesothelioma (MPM) is rare and aggressive cancer. The most important risk factor for MPM is exposure to asbestos. In this study, we scanned the genomes of individuals MPM and asbestos-induced chronic pleuritis (AICP) to co...
The Mutational and Transcriptional Landscapes of Speckle-Type POZ Protein (SPOP) and Androgen Receptor (AR) in a Single-Center pT3 Prostatectomy Cohort [0.03%]
单中心pT3前列腺切除队列中SPOP和AR的突变及转录组谱系分布研究
Isil Ezgi Eryilmaz,Berna Aytac Vuruskan,Onur Kaygisiz et al.
Isil Ezgi Eryilmaz et al.
Prostate cancer (PCa) is a heterogeneous disease both clinically and genetically. According to The Cancer Genome Atlas (TCGA), the speckle‑type POZ protein (SPOP) mutant form is one of the significant core subtypes of PCa. However, the pro...
Chemotherapeutic Drugs Endow Gastric Cancer Mesenchymal Stem Cells with Stronger Tumor-Promoting Ability [0.03%]
化疗药物赋予胃癌间充质干细胞更强的促肿瘤能力
Jiaqi Shen,Chao Huang,Linjing Cui et al.
Jiaqi Shen et al.
Gastric cancer (GC) is one of the most aggressive tumors and has a poor prognosis. It has been demonstrated that gastric cancer mesenchymal stem cells (GC-MSCs) can promote the progression, metastasis, and chemoresistance of GC through vari...
Differences between Urban and Rural Environments on Cardiovascular Health: A Systematic Review [0.03%]
城市和农村环境对心血管健康的影响差异：系统综述
Venetia Notara,Stamatia Kokkou,Emanouil Bindakos et al.
Venetia Notara et al.
The effect of the urban vs. rural environment on cardiovascular health is an extremely significant issue, nowadays. Up to date, there is a number of studies revealing that there is environmental impact on the prevalence of cardiovascular di...