Regulation and gene expression of heme synthesis under heavy metal exposure--review [0.03%]
重金属暴露条件下血红素生物合成的调节及基因表达综述分析
Avital Schauder,Almog Avital,Zvi Malik
Avital Schauder
Environmental pollution of heavy metals is very abundant nowadays from industry, chemicals, old paints, and pipes or resulting from previous contaminants accumulating in the food chain. Most of the iron demands of the body are needed for he...
Anti-tumor activity of Aloe vera against DMBA/croton oil-induced skin papillomagenesis in Swiss albino mice [0.03%]
Aloesin通过p53和EGFR信号通路抑制小鼠皮肤肿瘤生长的作用研究
M Saini,Pradeep Kumar Goyal,Geeta Chaudhary
M Saini
Human populations are increasingly exposed to various carcinogens such as chemicals, radiation, and viruses in the environment. Chemopreventive drugs of plant origin are a promising strategy for cancer control because they are generally non...
Diallyl disulfide induces caspase-dependent apoptosis via mitochondria-mediated intrinsic pathway in B16F-10 melanoma cells by up-regulating p53, caspase-3 and down-regulating pro-inflammatory cytokines and nuclear factor-κβ-mediated Bcl-2 activation [0.03%]
茋类化合物茋茋通过上调p53、caspase-3，下调核因子-κβ介导的Bcl-2活化及炎症介质诱导B16F-10黑色素瘤细胞线粒体依赖性半胱天冬酶途径的细胞凋亡
P Pratheeshkumar,P Thejass,Girija Kutan
P Pratheeshkumar
Diallyl disulfide (DADS) is a major organo-sulfur compound derived from garlic (Allium sativum), which inhibits the proliferation of various types of cancer cells. In this study we investigated the effect of DADS on the induction of apoptos...
Protective effect of Alstonia scholaris against radiation-induced clastogenic and biochemical alterations in mice [0.03%]
使用小鼠模型研究韦氏蛇根草对抗放射线诱发的染色体和生化改变的保护作用
Swafiya Jahan,Pradeep Kumar Goyal
Swafiya Jahan
We studied the radioprotective effect of Alstonia scholaris bark extract (ASE) on cytogenetic alterations in the form of chromosomal aberrations and micronuclei induction in bone marrow. For this purpose, one group of male Swiss albino mice...
Protective role of zinc in ameliorating arsenic-induced oxidative stress and histological changes in rat liver [0.03%]
锌通过缓解氧化应激和组织学变化对抗砷引起的肝毒性作用的保护作用研究
Ashok Kumar,Anshoo Malhotra,Praveen Nair et al.
Ashok Kumar et al.
The aim of present work was to gain insight into the role of dietary zinc in ameliorating the adverse effects caused by arsenic on rat liver. Male Wistar rats received arsenic alone in the form of sodium arsenite in drinking water at a dose...
Richard F Edlich,Shelley S Mason,Jill S Reddig et al.
Richard F Edlich et al.
Vitamin D deficiency has bee associated with bone diseases, cardiovascular diseases, cancer, and multiple sclerosis. Recent clinical studies have pointed out that these diseases could be prevented by either adequate sun exposure or oral vit...
Richard F Edlich,Shelley S Mason,Jill S Reddig et al.
Richard F Edlich et al.
The associate director for science and medicine in the Office of Drug Safety at the Food and Drug Administration (FDA), Dr. David Graham, reported that the FDA was incapable of protecting Americans from unsafe drugs. In testimony to the Sen...
Bola Sadashiva Satish Rao,Nageshwar Rao,P R Archana et al.
Bola Sadashiva Satish Rao et al.
The present study was undertaken to investigate the radiation mitigating effect of hydro-alcoholic extract of Saraca indica (SIE) against mice exposed to whole body gamma radiation. Free radical scavenging ability by SIE was demonstrated us...
Black tea polyphenol (theaflavin) downregulates MMP-2 in human melanoma cell line A375 by involving multiple regulatory molecules [0.03%]
红茶茶黄素通过多种调节分子下调恶性黑色素瘤细胞中MMP-2的表达
Hrishikesh Sil,Triparna Sen,Shuvojit Moulik et al.
Hrishikesh Sil et al.
The tumor-inhibiting property of black tea polyphenol, theaflavin, is well documented. Matrix metalloproteinases (MMPs) play a pivotal role in tumor invasion through degradation of extracellular matrix (ECM). In the present study, we observ...
Induction of apoptosis as a potential chemopreventive effect of dual cycloxygenase inhibitor, diclofenac, in early colon carcinogenesis [0.03%]
非甾体抗炎药Diclofenac在早期结肠癌变中诱导凋亡的潜在化学预防作用
Sankar Nath Sanyal,Jasmeet Kaur
Sankar Nath Sanyal
We evaluated the role of diclofenac, a dual cycloxygenase inhibitor, in chemoprevention of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in rat model. In a six-week long treatment with DMH (initiation stage), colonic mucosa showe...