STAT1 Mediates the Transcription of CircIFI30 and Promotes the Progression of Triple-Negative Breast Cancer by Up-Regulating CDCA4 [0.03%]
STAT1介导CircIFI30转录并通过上调CDCA4促进三阴性乳腺癌进展
Jie Zhang,Shufeng Xia,Xiaoyu Liu et al.
Jie Zhang et al.
Signal transducers and activators of transcription 1 (STAT1) is an important transcription factor that regulates the growth, survival, differentiation and apoptosis of various tumor cells. However, the biological roles of STAT1 and potentia...
Propofol Ameliorates the Proliferation and Epithelial-Mesenchymal Transition of Hepatoma Carcinoma Cells via Non-Coding RNA Activated by DNA Damage (NORAD)/microRNA (miR)-556-3p/Migration and Invasion Enhancer 1 (MIEN1) Axis [0.03%]
丙泊酚通过DNA损伤激活的非编码RNA(NORAD)/微小核糖核酸(miR)-556-3p/迁移和侵袭增强子1(MIEN1)轴改善肝癌细胞增殖及上皮间质转化
Yanna Liu,Xiang Wang,Hongyu Li et al.
Yanna Liu et al.
Propofol has been previously demonstrated to relieve hepatocellular carcinoma (HCC). However, the specific molecular mechanisms mediated by propofol remain to be explored. mRNA or miRNA expression was detected by real-time quantitative poly...
Differential Analysis of IncRNAs and mRNAs Expression in HCC and the Predictive Value of lncRNAs [0.03%]
肝癌中IncRNA和mRNA表达的差异分析及lncRNA的预测价值
Lei Shi,Qi Wang,Jie Lv et al.
Lei Shi et al.
Background: Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death. However, the molecular mechanism of its pathogenesis is still unclear. This study analyzed the pathophysiology of HCC based o...
Targeting Neuregulin 1 (NRG1): A Novel Biomarker for Non-Small-Cell Lung Cancer [0.03%]
靶向神经调节蛋白1(NRG1)：非小细胞肺癌新型生物标志物
Chun Fang,Baoguo Kang,Pan Zhao et al.
Chun Fang et al.
The aim of this study was to identify the roles of neuregulin 1 (NRG1) during the tumor progression in non-small-cell lung cancer (NSCLC). NSCLC patients with lung squamous cell carcinoma and lung adenocarci-noma were enrolled in this study...
Potential of Curcumin and Quercetin in Modulation of Premature Mitochondrial Senescence and Related Changes during Lung Carcinogenesis [0.03%]
姜黄素和芦丁在肺部癌变过程中调节细胞线粒体早衰及相关变化的潜在作用
Wenfu Wang,Ying Xie,Anshoo Malhotra
Wenfu Wang
Ferroptosis is a classification of programmed cell death, which activates oxidative cell death in an iron and lipid peroxides-dependent manner. Targeting ferroptosis is a novel therapeutic approach for cancer therapy. Lung cancer is the lea...
Metabolomics Approach to the Exploration of Amino Acids Metabolism Changes Associated with Disease Progression in a Rat Model of Adjuvant-Induced Arthritis [0.03%]
代谢组学方法探索完全弗氏佐剂诱导的关节炎疾病进程中氨基酸代谢变化
Yi Liu,Yunfei Xie
Yi Liu
The disease progression of rheumatoid arthritis (RA) is closely related to the disorder of amino acids metabolism. This study aimed to clarify the changes in the categories, quantities and metabolic pathways of amino acids associated with d...
Recent Evidence and Possible Therapy against COVID-19-Mediated Hepatic Dysfunction [0.03%]
关于COVID-19介导的肝功能不全的最新证据和可能疗法
Nemat Ali
Nemat Ali
Over the years, a novel RNA coronavirus has emerged with mutational episodes. This virus was confirmed to cause severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus infectious disease-2019 (COVID-19). This particular...
HDAC3-Mediated Repression of LncRNA-LET Regulates Gastric Cancer Cell Growth Proliferation, Invasion, Migration, and Apoptosis via MiR-548k [0.03%]
HDAC3介导的长链非编码RNA-LET抑制调节MiR-548k胃癌细胞生长增殖，侵袭，迁移和凋亡
Jie Zhang,Xiaoyu Liu,Jun Chen et al.
Jie Zhang et al.
Emerging studies have indicated the aberrant expression of histone deacetylases (HDACs) is closely associated with the development of tumors. However, the regulatory roles of HDACs-regulated long noncoding RNAs (lncRNA) in gastric cancer (G...
Troxerutin Abrogates Ischemic/Reperfusion-Induced Brain Injury through Ameliorating Oxidative Stress and Neuronal Inflammation by Inhibiting the Expression of NLRP3 in Sprague Dawley Rats [0.03%]
芦丁通过抑制NLRP3表达缓解氧化应激和神经炎症从而对抗SD大鼠脑缺血再灌注损伤的作用及机制研究
Chao Gao,Yunfei Song,Taotao Dou et al.
Chao Gao et al.
Cerebral ischemic reperfusion (I/R) infarction is mostly associated with serious brain injury, cognitive damage, and neurological deficits. The oxidative stress mechanisms in the neurological region lead to higher reactive oxygen species pr...
T3 Promotes Glioma Cell Senescence and Apoptosis via THRA and THRB [0.03%]
T3通过THRA和THRB促进胶质瘤细胞衰老和凋亡
Xingkui Zhang,Wei Ma,Junjun Li et al.
Xingkui Zhang et al.
Glioma is one of the most common types of primary intracranial tumors. The relationship between triiodothyronine (T3) and glioma is not clear. This study aimed to investigate the effect of T3 on the proliferation of glioma cells and its mec...