Bioinformatics Unveils Key Genes in the MAPK Pathway in Colorectal Cancer and Predicts Prognosis, Immune Characteristics, and Potential Drugs [0.03%]
生物信息学揭示结直肠癌MAPK途径的关键基因及其预后、免疫特征和潜在药物预测
Huixuan Hou,Long Zhang,Hualing Duan
Huixuan Hou
Background: The Mitogen-Activated Protein Kinase (MAPK) signaling pathway is significant in clinical practice for its potential to impede tumor proliferation and migration and to enhance patient prognosis. Yet, the specif...
Recent Advances in Medicinal Plant Research for Mitigating Aluminium Toxicity [0.03%]
近期关于药用植物研究的进展：缓解铝毒性的方法
Sanjib Bhattacharya
Sanjib Bhattacharya
Aluminium is the third common metal of the earth, yet, it is physiologically non-essential and its higher levels on regular exposure can be harmful to the human body, affecting many vital organ systems. Environmental aluminium contamination...
DACT1 as a Potential Therapeutic Target in Gastric Cancer: Insights from Integrative Bioinformatics and Experimental Analysis [0.03%]
DACT1作为胃癌治疗靶点的潜力：综合生物信息学和实验分析的启示
Rui-Sheng Ke,Bing Bai,Yan-Ling Tu et al.
Rui-Sheng Ke et al.
Gastric cancer (GC) remains a significant worldwide health issue, Dapper Antagonist of β-Catenin-1 (DACT1) is a gene implicated in various cancers. Bioinformatics analysis across multiple databases were utilized to investigate DACT1 expres...
Antitumor Effect of 5-Aminolevulinic Acid Methyl Ester-Mediated Photodynamic Therapy on Local Skin Melanoma and Its Metastasized Tumor, in Relation with Antitumor Immunity [0.03%]
叶酸介导的光动力疗法抗肿瘤效应及其与抗肿瘤免疫的关系研究
Mima Danzeng,Li Anxin,Gongsang Duoji et al.
Mima Danzeng et al.
Objective of the present study is to investigate the effect of photodynamic therapy (PDT) mediated by 5-aminolevulinic acid methyl ester hydrochloride (ALA-Me) on inhibiting the primary tumor growth and metastasis of melanoma, in relation w...
Prediction of Prognosis, Tumor Microenvironment, and Drug Treatment of Colorectal Cancer Based on Retinoic Acid-Related Genes [0.03%]
基于视黄酸相关基因的结直肠癌预后、肿瘤微环境及药物治疗预测研究
Yuecheng Wang,Rui Feng,Rui Shang
Yuecheng Wang
Colorectal cancer (CRC) is a serious malignancy. Retinoic acid (RA) can inhibit cancer cell growth, promote cancer cell apoptosis, and hold significant importance for tumor prognosis. We utilized TCGA public data to screen RA-related genes ...
LncRNA GHET1 Overexpression Facilitates Cancer Progression and Is an Unfavorable Prognosis Factor in Esophageal Cancer [0.03%]
长链非编码RNA GHET1过表达促进食管癌进展并是一个不良预后因素
Jin Zhang,Yaohua Chen
Jin Zhang
Aim: This research sought to estimate the prognostic performance and cellular behaviors of lncRNA GHET1 (gastric carcinoma highly expressed transcript 1) in sufferers of esophageal cancer. ...
lncRNA FENDRR as a Prognostic Biomarker and Regulator of Bladder Cancer Progression via the miR-18a-5p/ESR1 Axis [0.03%]
长链非编码RNA FENDRR通过miR-18a-5p/ESR1轴作为预后生物标志物和调节因子促进膀胱癌进展
Chao Gao,Xiliang Cao,Long Miao et al.
Chao Gao et al.
Recent research highlights the pivotal function of long non-coding RNAs (lncRNAs) in bladder cancer (BCa) progression, emphasizing the need to understand their functions. The clinical significance and molecular mechanisms of lncRNA FENDRR i...
Kanishka Alagar Raja,Kunnathur Murugesan Sakthivel,Venugopal Vinod Prabhu et al.
Kanishka Alagar Raja et al.
Neuro-oncology is the study of brain and spinal cord neoplasms. Molecular targets and signaling pathways are pivotal in advancing modern healthcare, particularly in personalized medicine. Signaling pathways, which regulate cellular processe...
Radiotherapy-Related Autophagy Genes Predict Prognosis and Reveal Immunoscape Features and Immunotherapeutic Agents in Colorectal Cancer Patients [0.03%]
放疗相关自噬基因预测结直肠癌患者预后及揭示免疫特征和免疫治疗药物响应
Mao Mao,Yichao Zhuang,Yan Chen
Mao Mao
Numerous genes have been associated with colorectal cancer (CRC) treatment in prior studies, but the impact of radiotherapy-related autophagy genes (RRAGs) on CRC remains largely unexplored. The Cancer Genome Atlas (TCGA) and Gene Expressio...
Identification of Lung Adenocarcinoma Subtypes Based on Nicotinamide Metabolism-Related Genes to Assess Prognosis and Immunotherapy [0.03%]
基于烟酰胺代谢相关基因鉴定肺癌亚型以评估预后和免疫治疗
Meijun Peng,Qiuli Ding
Meijun Peng
Background: Lung adenocarcinoma (LUAD) is one of the most malignant tumors with significant implications for population health and life. Nicotinamide metabolism may play a pivotal part in influencing the prognosis of LUAD...