Modular formation of in vitro tumor models for oncological research/therapeutic drug screening [0.03%]
用于肿瘤学研究/治疗药物筛选的体外肿瘤模型的模块化构建
Weiwei Wang,Hongjun Wang
Weiwei Wang
In recognition of the lethal nature of cancer, extensive efforts have been made to understand the mechanistic causation while identifying the effective therapy modality in hope to eradicate cancerous cells with minimal damage to healthy cel...
Crosstalk between tumor and microenvironment: Insights from spatial transcriptomics [0.03%]
肿瘤与微环境的相互作用：空间转录组学带来的启示
Malvika Sudhakar,Harie Vignesh,Kedar Nath Natarajan
Malvika Sudhakar
Cancer is a dynamic disease, and clonal heterogeneity plays a fundamental role in tumor development, progression, and resistance to therapies. Single-cell and spatial multimodal technologies can provide a high-resolution molecular map of un...
Advancing cancer therapeutics: Integrating scalable 3D cancer models, extracellular vesicles, and omics for enhanced therapy efficacy [0.03%]
肿瘤治疗新进展：整合可扩展的三维癌症模型、细胞外囊泡和组学以增强治疗效果
Pedro P Gonçalves,Cláudia L da Silva,Nuno Bernardes
Pedro P Gonçalves
Cancer remains as one of the highest challenges to human health. However, anticancer drugs exhibit one of the highest attrition rates compared to other therapeutic interventions. In part, this can be attributed to a prevalent use of in vitr...
Applications of spatial transcriptomics and artificial intelligence to develop integrated management of pancreatic cancer [0.03%]
空间转录组学和人工智能在胰腺癌综合管理中的应用
Rishabh Maurya,Isha Chug,Vignesh Vudatha et al.
Rishabh Maurya et al.
Cancer is a complex disease intrinsically associated with cellular processes and gene expression. With the development of techniques such as single-cell sequencing and sequential fluorescence in situ hybridization (seqFISH), it was possible...
Deep learning-based multimodal spatial transcriptomics analysis for cancer [0.03%]
基于深度学习的癌症多模态空间转录组学分析
Pankaj Rajdeo,Bruce Aronow,V B Surya Prasath
Pankaj Rajdeo
The advent of deep learning (DL) and multimodal spatial transcriptomics (ST) has revolutionized cancer research, offering unprecedented insights into tumor biology. This book chapter explores the integration of DL with ST to advance cancer ...
Nathaniel Oberholtzer,Stephanie Mills,Shubham Mehta et al.
Nathaniel Oberholtzer et al.
It has been well established that in addition to oxygen's vital in cellular respiration, a disruption of oxygen balance can lead to increased stress and oxidative injury. Similarly, reduced oxygen during tumor proliferation and invasion gen...
Gunjan Purohit,Polash Ghosh,Oleh Khalimonchuk
Gunjan Purohit
Our understanding of the roles that mitochondria play in cellular physiology has evolved drastically-from a mere cellular energy supplier to a crucial regulator of metabolic and signaling processes, particularly in the context of developmen...
Colin L Welsh,Lalima K Madan
Colin L Welsh
Protein Tyrosine Phosphatases (PTPs) help to maintain the balance of protein phosphorylation signals that drive cell division, proliferation, and differentiation. These enzymes are also well-suited to redox-dependent signaling and oxidative...
Therese Featherston,Martina Paumann-Page,Mark B Hampton
Therese Featherston
Melanoma is the deadliest form of skin cancer, with the loss of approximately 60,000 lives world-wide each year. Despite the development of targeted therapeutics, including compounds that have selectivity for mutant oncoproteins expressed o...
Jie Zhang,Zhi-Wei Ye,Danyelle M Townsend et al.
Jie Zhang et al.
Cases of melanoma are doubling every 12 years, and in stages III and IV, the disease is associated with high mortality rates concomitant with unresectable metastases and therapeutic drug resistance. Despite some advances in treatment succes...