AEG-1 on cancer drug resistance: From molecular insights to therapeutic challenges [0.03%]
癌细胞药物抗性中的AEG-1：从分子机理到治疗挑战
Wali Ullah,Hail Kim,Sanghee Han et al.
Wali Ullah et al.
Astrocyte elevated gene-1 (AEG-1), also known as metadherin (MTDH), has emerged as a multifunctional oncogene implicated in cancer progression, metastasis, immune evasion, and notably, drug resistance across diverse malignancies. AEG-1 exer...
Enzymes of the outer mitochondrial membrane regulating cholesterol and fatty acid metabolism in cancer [0.03%]
调节胆固醇和脂肪酸代谢的癌外线粒体膜酶
Leilei Zhang,Milagros Junco,Danyelle M Townsend et al.
Leilei Zhang et al.
Mitochondria are major sites of ATP production, also serving as metabolic and biosynthetic hubs. The structure of mitochondria comprises a matrix enclosed by an inner membrane which is separated from the outer mitochondrial membrane (OMM) b...
Epigenetic mechanisms and therapeutic advances in breast cancer: From molecular insights to clinical applications [0.03%]
乳腺癌的表观遗传机制和治疗进展：从分子见解至临床应用
Shahid Maqbool Mir,Joseph W Landry,Swadesh K Das et al.
Shahid Maqbool Mir et al.
Breast cancer remains the most frequently diagnosed cancer and a leading cause of cancer-related mortality in women globally. While genetic mutations are well-established contributors to breast cancer pathogenesis, accumulating evidence und...
PROTACS- targeted protein degradation as a path to precision cancer therapeutics [0.03%]
利用靶向蛋白降解的精准癌症治疗(PROTACs)
Hannah R Gatley,Paul B Fisher,Swadesh K Das
Hannah R Gatley
New strategies and mechanisms for managing and treating cancer are essential; a novel therapeutic approach has now emerged in the scope of targeted protein degradation called Proteolysis-Targeting Chimeras (PROTACs). This technology specifi...
Meghna Mehta,Dinesh Babu Somasundaram,Anupama Munshi et al.
Meghna Mehta et al.
Medulloblastoma (MB) stands out as the most prevalent, invasive, and biologically heterogeneous pediatric brain tumor. MB accounts for almost 1/4th of all intracranial neoplasms. The prime age of diagnosis is 5-9 years of age; however, the ...
Kenneth D Tew,Danyelle M Townsend,Leilei Zhang et al.
Kenneth D Tew et al.
Some of the earliest anticancer drugs were alkylating agents, capable of covalently modifying critical cellular nucleophiles in proteins and nucleic acids. For many years, adapting another type of covalent reaction, Michael addition reactio...
Gurnit Kaur,Negar Ghaffari,Nagesh Kalakonda et al.
Gurnit Kaur et al.
Acute myeloid leukemia is a poor prognostic blood cancer with dismal survival rates. Major challenges in improving AML survivorship include its heterogeneity and ability to evade immunosurveillance. To facilitate subtyping and therapeutic d...
AI-driven parametric FDG brain PET and brain tumor segmentation for multi-modal convolution neural network to differentiate tumor progression from treatment effect in GBM [0.03%]
基于人工智能的参数FDG脑PET和脑肿瘤分割以区分多模态卷积神经网络中的胶质母细胞瘤进展与治疗作用
Bijoy Kundu,Zoraiz Qureshi,Rugved Chavan et al.
Bijoy Kundu et al.
Glioblastoma (GBM) accounts for 52 % of all malignant primary brain tumors. The main treatment regimens include surgical resection followed by chemoradiotherapy. Despite these, the median survival of patients with GBM is only 15 months. To ...
Arka Saha,Avri Ben-Ze&#x;ev
Arka Saha
Cell adhesion molecules (CAMs) mediate cellular adhesions to neighboring cells and the extracellular matrix (ECM) to regulate tissue homeostasis and morphogenesis. Dysfunctional CAM-mediated signaling is required for a neoplastic cell to ga...
Mohamed S Abdelbaki,Paul B Fisher,David D Limbrick Jr
Mohamed S Abdelbaki