Jacqueline Carmona,Deon Nguyen,Masmudur M Rahman
Jacqueline Carmona
Viruses have been developed as oncolytic immunotherapy agents due to their ability to target and kill cancer cells while sparing normal cells. Additionally, engineered oncolytic viruses (OVs) can alter the immunosuppressive tumor microenvir...
Cancer terminator viruses: Unique conditionally replication competent oncolytic viruses producing therapeutic anti-cancer immunomodulating agents [0.03%]
抗癌肿瘤终止病毒：可条件复制的抗肿瘤溶瘤病毒，能够产生治疗性抗癌免疫调节剂
Pritam Kumar Roy,Shahid Maqbool Mir,Narsimha Mamidi et al.
Pritam Kumar Roy et al.
Cancer terminator viruses (CTVs) are next‑generation conditionally replicating oncolytic adenoviruses that integrate precise tumor targeting, direct oncolysis, and potent cytokine‑mediated immunotherapy into a single platform. In CTVs, vi...
Margarita Romanenko,Julia Davydova
Margarita Romanenko
Viruses are extraordinary products of evolution that can be harnessed as versatile platforms for cancer therapy. They replicate in tumor cells, induce lysis, and stimulate antitumor immunity. Among viral platforms, oncolytic adenoviruses (O...
Kenny Voon,Zhen Yun Siew
Kenny Voon
Reoviruses have emerged as promising oncolytic agents, exploiting their natural tropism for transformed cells with aberrant Ras signaling to enable selective replication and tumor cell lysis. The most clinically advanced candidate, Mammalia...
Myungeun Lee,Jinhyun Park,Ji Hoon Park et al.
Myungeun Lee et al.
Current cancer therapies, including cytotoxic agents, molecularly targeted drugs, and immune-based treatments, are often constrained by therapeutic resistance, systemic toxicity, and inconsistent clinical efficacy. The adeno-associated viru...
Vesicular stomatitis virus (VSV) as an oncolytic therapeutic agent for cancer [0.03%]
作为癌症溶瘤治疗剂的囊斑口炎病毒(VSV)
Jennifer Altomonte
Jennifer Altomonte
Vesicular stomatitis virus (VSV), an enveloped RNA virus that naturally infects livestock, has emerged as a highly versatile and potent platform for research purposes and, especially, for oncolytic virotherapy. The unique advantages of VSV ...
Ana Laura Vieira Alves,Bianca Naomi Niitsuma,Fernanda Antunes et al.
Ana Laura Vieira Alves et al.
While there are many choices among gene transfer vectors for basic or applied research, non-replicating adenoviruses are among the most studied. The virus is well suited for in vivo gene therapy since the vector can be produced with relativ...
Eric Hawley,Milan G Chheda
Eric Hawley
Glioblastoma (GBM) is a common, aggressive, primary brain tumor. New therapies are needed to improve outcomes in patients with this disease. One such approach which has shown preclinical promise is the use of genetically engineered Zika vir...
Oncolytic viruses in cutaneous oncology: Mechanisms, clinical applications, and future directions [0.03%]
溶瘤病毒在皮肤病学中的应用：机制、临床应用及未来方向
Goranit Sakunchotpanit,Mihir K Patil,Ruhi Kanwar et al.
Goranit Sakunchotpanit et al.
Oncolytic viruses (OVs) are a rapidly expanding class of anti-neoplastic management options that utilize the innate infectivity of either native or modified viruses to preferentially lyse malignant cells while sparing healthy ones. Some OVs...
Piyal Mukherjee,Manoj Kumar Jana,Arthita Dutta et al.
Piyal Mukherjee et al.
Over the past few years, targeted therapy has become the backbone of precision oncology, with personalized treatment plans shaped by the individual tumor's molecular and genetic profile. Underpinning this treatment approach, biomarkers enab...