Irene Zebochin,Franziska Denk,Zahra Nochi
Irene Zebochin
The study of pain mechanisms has advanced significantly with the development of innovative in vitro models. This chapter explores those already used in or potentially useful for neuropathic pain research, emphasizing the complementary roles...
Small fiber neuropathy [0.03%]
小纤维神经病
Dennis Kool,Janneke Gj Hoeijmakers,Stephen G Waxman et al.
Dennis Kool et al.
Small fiber neuropathy (SFN) is a condition involving the small nerve fibers of the peripheral nervous system, specifically the thinly myelinated Aδ and unmyelinated C fibers. It is an increasingly acknowledged condition within the spectru...
Simple Futarmal Kothari,Christina Emborg,Lene Vase
Simple Futarmal Kothari
Management of neuropathic pain is exceptionally challenging and development of new drugs and ways to optimize treatment effects in clinical practice are needed. Over the last decade, some of the mechanisms underlying placebo effects have be...
Michèle Hubli,Caterina Leone
Michèle Hubli
Timely and accurate diagnosis of neuropathic pain is critical for optimizing therapeutic outcomes and minimizing treatment delays. According to current standards, the diagnosis of definite neuropathic pain requires objective confirmation of...
Neuroanatomy of the nociceptive system: From nociceptors to brain networks [0.03%]
伤害性系统的神经解剖学：从伤害感受器到脑网络
Julian C Motzkin,Allan I Basbaum,Andrew J Crowther
Julian C Motzkin
This chapter reviews the neuroanatomy of the nociceptive system and its functional organization. We describe three main compartments of the nervous system that underlie normal nociception and the resulting pain percept: Peripheral, Spinal C...
Rosana Camarini,Fábio C Cruz
Rosana Camarini
The CRF/Urocortin systems as therapeutic targets for alcohol use disorders [0.03%]
CRF/乌黑皮素系统作为酒精使用障碍的治疗靶点
Cristiane Aparecida Favoretto,Natalia Bonetti Bertagna,Tarciso Tadeu Miguel et al.
Cristiane Aparecida Favoretto et al.
Development and maintenance of alcohol use disorders have been proposed to recruit critical mechanisms involving Corticotropin Releasing Factor and Urocortins (CRF/Ucns). The CRF/Ucns system is comprised of a family of peptides (CRF, Ucn 1,...
Emerging evidence for pregnane steroid therapeutics for alcohol use disorders [0.03%]
孕烷类固醇治疗酒精使用障碍的新证据
A Leslie Morrow,Minna H McFarland,Todd K O&#x;Buckley et al.
A Leslie Morrow et al.
Many lines of research have suggested that the neuroactive pregnane steroids, including pregnenolone, progesterone, and allopregnanolone ([3α,5α]-3-hydroxypregnan-20-one, 3α,5α-THP), have therapeutic potential for treatment of alcohol u...
Ghrelin system and GLP-1 as potential treatment targets for alcohol use disorder [0.03%]
胃促生长素系统和GLP-1作为酒精使用障碍的潜在治疗靶点
Elisabet Jerlhag
Elisabet Jerlhag
Peptides of the gut-brain axis have gained recent attention as potential treatment targets for addiction. While the number of gut-brain peptides is vast, ghrelin and glucagon-like peptide-1 (GLP-1) have been suggested as important players. ...
Laís F Berro,James K Rowlett,Donna M Platt
Laís F Berro
Decades of research have implicated the gamma-aminobutyric acid (GABA)ergic system as one of the main mediators of the behavioral effects of alcohol. Of importance, the addiction-related effects of alcohol also have been shown to be mediate...