Therapeutic targeting of brain bioenergetics in Alzheimer's disease addressing insulin resistance, glucose hypometabolism, and mitochondrial dysfunction [0.03%]
针对阿尔茨海默病的脑生物能治疗靶点：解决胰岛素抵抗、葡萄糖低代谢和线粒体功能障碍
Jatin Jangra,Isha Mahindru,Rajnish Kumar
Jatin Jangra
Alzheimer's disease (AD) is a progressive, age-associated multifactorial neurodegenerative disorder characterised by cognitive decline, synaptic dysfunction, and neuronal loss. Despite over a century of research, effective disease-modifying...
Insulin resistance and obesity: Drivers of energy crisis for Alzheimer's disease [0.03%]
胰岛素抵抗和肥胖：阿尔茨海默病能量危机的驱动因素
Pooja Singh,Bhupesh Vaidya,Pallavi Upadhayay et al.
Pooja Singh et al.
Alzheimer's disease (AD) is increasingly recognized as a disorder driven not only by classical neuropathological hallmarks but also by profound disturbances in brain energy metabolism. Growing evidence points to insulin resistance and obesi...
Glial molecular signatures as a liquid biopsy marker in Alzheimer's disease diagnosis [0.03%]
阿尔茨海默病诊断中以胶质细胞分子特征作为液体活检标志物的研究
Kunal Yadav,Sachin Suresh Tiwari
Kunal Yadav
Alzheimer's disease (AD) is a neurodegenerative condition that is characterized by the misfolding of Amyloid Precursor Protein, hyperphosphorylation of tau protein, and neuroinflammation. This leads to the formation of extracellular senile ...
Metabolic drivers of Alzheimer's disease pathogenesis: Impairments in glucose utilization, lipid homeostasis, and alternative substrate metabolism [0.03%]
阿尔茨海默病发病机制的代谢驱动因素：葡萄糖利用、脂质稳态及替代底物代谢异常
Shiva Chaudhary,Shreya Verma,Vidisha Kumari et al.
Shiva Chaudhary et al.
Alzheimer's disease (AD) is one of the widespread neurodegenerative disorders, marked by the accumulation of amyloid-β plaques, neurofibrillary tangles of hyperphosphorylated Tau protein, and the gradual loss of neurons. While genetic and ...
Activation of Nrf2 neuroprotective pathways for treatment of Parkinson's disease: A state of art review [0.03%]
激活Nrf2神经保护途径治疗帕金森病：现状分析
Anastasia Bougea
Anastasia Bougea
The regulation of Nuclear Factor-Erythroid 2 Like 2 (NRF2) signaling has been shown to be a promising strategy to modulate the progression of the neurodegeneration associated to Parkinson's Disease (PD). Aim of this review is to update the ...
Metabolic reprogramming in Alzheimer's disease: Interaction between receptor tyrosine kinase signaling, noncoding RNAs, and Neuron-Glia energy networks [0.03%]
阿尔茨海默病中的代谢重组：受体酪氨酸激酶信号、非编码RNA和神经胶质能量网络之间的相互作用
Ankita Karmakar,Puja Roycowdhury,Priyanka Sengupta et al.
Ankita Karmakar et al.
Alzheimer's disease (AD) is increasingly understood as a disorder involving impaired brain energy metabolism rather than being solely caused by amyloid and tau pathology. This chapter offers a comprehensive overview of how glucose hypometab...
Sangita Rajkhowa,Timir Tripathi
Sangita Rajkhowa
Tau is a microtubule-associated protein that plays a central role in neuronal stability and axonal transport. However, under pathological conditions, it undergoes structural and functional changes that lead to Alzheimer's disease (AD) and r...
Marcos V de S Pereira,Jemmyson R de Jesus
Marcos V de S Pereira
This chapter critically explores the role of metallospecies homeostasis in the pathophysiology of Alzheimer's disease (AD), going beyond the traditional amyloid protein-centered approach. The discussion integrates biochemical, molecular, an...
Bioenergetic impairment-induced Tau acetylation: Converging pathways in Alzheimer's disease [0.03%]
线粒体功能损伤诱导的Tau乙酰化：阿尔茨海默病中的趋同通路
Basavaraju K C,Poornima Priyadarshini
Basavaraju K C
Alzheimer's disease (AD) is increasingly recognized as a metabolic disorder in which disruptions in cellular energy metabolism play a central role in its progression. The dysregulated metabolism of carbohydrates, proteins, fatty acids, and ...
Genetic and epigenetic complexity of Parkinson's disease: From dopamine pathways to estrogen interplay [0.03%]
帕金森病的遗传与表观遗传复杂性：从多巴胺通路到雌激素交互作用
Krishnan Deena,Lakshman Nathish,Er Antony Fenwick et al.
Krishnan Deena et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by selective loss of nigrostriatal dopaminergic neurons and extensive circuit disruption, clinically presenting with motor deficits and many non-motor sympto...