Dysbiosis significantly elevates the probability of altered affective function in Alzheimer disease (AD) [0.03%]
菌群失调可显著提高阿尔茨海默病患者情绪改变的概率
Harsh Kumar,Daljeet Singh Dhanjal,Rajni Dhalaria et al.
Harsh Kumar et al.
Changes in the makeup of gut microbiota are linked to many neuropsychiatric diseases. Although the exact connection between gut dysbiosis and brain dysfunction is not yet fully understood, but recent data suggests that gut dysbiosis may con...
Regional and interregional functional and structural brain abnormalities in neuropathic pain [0.03%]
神经病理性疼痛的脑功能和结构异常：区域性与跨区域性分析
Rima El-Sayed,Karen Deborah Davis
Rima El-Sayed
Neuropathic pain is a severe form of chronic pain due to a lesion or disease of the somatosensory nervous system. Here we provide an overview of the neuroimaging approaches that can be used to assess brain abnormalities in a chronic pain co...
Sam Hughes,Jan Vollert,Roy Freeman et al.
Sam Hughes et al.
The methodology of Quantitative Sensory Testing (QST) comprises standardized testing procedures, which provide information of the integrity of the somatosensory nervous system. Over the years, different protocols have been established, whic...
Pedro Henrique Martins da Cunha,Jorge Dornellys da Silva Lapa,Koichi Hosomi et al.
Pedro Henrique Martins da Cunha et al.
The treatment of neuropathic pain (NeP) often leads to partial or incomplete pain relief, with up to 40 % of patients being pharmaco-resistant. In this chapter the efficacy of neuromodulation techniques in treating NeP is reviewed. It prese...
Psychological, physical and complementary therapies for the management of neuropathic pain [0.03%]
神经性疼痛的管理：心理、物理和补充疗法
Nell Norman-Nott,Aidan G Cashin,Sylvia M Gustin
Nell Norman-Nott
This chapter aims to explain and evaluate the evidence for psychological, physical and complementary therapies as part of a holistic plan for managing neuropathic pain. Psychological therapies refer to interventions targeting mental health,...
Jan Rosner,Prasad Shirvalkar,Daniel Ciampi de Andrade
Jan Rosner
Neuropathic pain is used both as a mechanistic descriptor and a classification category of pain caused by a lesion or disease of the somatosensory nervous system and encompasses a vast array of possible diagnoses. The identification of neur...
Jan Rosner,Nadine Attal,Nanna B Finnerup
Jan Rosner
This chapter aims to review the current pharmacological options for neuropathic pain treatment, their mechanisms of action, and future directions for clinical practice. Achieving pain relief in neuropathic pain conditions remains a challeng...
Angela M Casaril,Caitlyn M Gaffney,Andrew J Shepherd
Angela M Casaril
Animal models continue to be crucial to developing our understanding of the molecular, cellular, and neurophysiological mechanisms that lead to neuropathic pain. The overwhelming majority of animal studies use rodent models, ranging from su...
Exploring neuroinflammation: A key driver in neuropathic pain disorders [0.03%]
探究神经炎症：神经病理性疼痛障碍的关键驱动因素
Paulina S Scheuren,Margarita Calvo
Paulina S Scheuren
Inflammation is a fundamental part of the body's natural defense mechanism, involving immune cells and inflammatory mediators to promote healing and protect against harm. In the event of a lesion or disease of the somatosensory nervous syst...
Paola Pacifico,Daniela M Menichella
Paola Pacifico
Peripheral neuropathic pain, which occurs after a lesion or disease affecting the peripheral somatosensory nervous system, is a complex and challenging condition to treat. This chapter will cover molecular mechanisms underlying the pathophy...