Animal models for studying therapeutic targets and treatments for alcohol use disorder [0.03%]
酒精使用障碍治疗靶点和疗法研究的动物模型
Cristiane Aparecida Favoretto,Thamires Righi,Gustavo Juliate Damaceno Fernandes et al.
Cristiane Aparecida Favoretto et al.
Over the decades, preclinical models have been developed and refined to investigate the rewarding effects of addictive substances and the neurobiological underpinnings of alcohol and other drug use disorders. This chapter delves into the me...
Environmental enrichment and complementary clinical interventions as therapeutic approaches for alcohol use disorder in animal models and humans [0.03%]
动物模型和人类中的酒精使用障碍治疗途径的环境丰富度和临床补充干预措施
Rosana Camarini,Priscila Marianno,Beatriz Yamada Costa et al.
Rosana Camarini et al.
Alcohol use disorder (AUD) is a multifactorial disorder arising from a complex interplay of various genetic, environmental, psychological, and social factors. Environmental factors influence alcohol misuse and can lead to AUD. While stress ...
Júlia Dalfovo Marquez,Talissa Dezanetti,Roger Walz et al.
Júlia Dalfovo Marquez et al.
Several pieces of evidence have implicated the endocannabinoid system on dopaminergic mesolimbic brain reward, as well as the potential role of cannabinoid receptors CB1 and CB2 on modulation of reinforced properties of drug abuse and conse...
Eduardo A V Marinho,Yasmim A Serra,Alexandre J Oliveira-Lima et al.
Eduardo A V Marinho et al.
For decades, psychedelics have been investigated for the treatment of psychiatric disorders. Specifically, evidence suggests that psychedelics may have therapeutic potential for the treatment of alcohol use disorder. Several studies with cl...
Sutton M Scarboro,Marcelo F López,Howard C Becker
Sutton M Scarboro
Published works highlight the role of neuropeptides in both the development and treatment of AUD. Closely related hypothalamic neuropeptides, oxytocin (OT) and vasopressin (VP), initially recognized for their physiological hormone effects, ...
Sodium oxybate: A comprehensive review of efficacy and safety in the treatment of alcohol withdrawal syndrome and alcohol dependence [0.03%]
钠氧bate治疗酒精戒断综合征和酒精依赖的疗效和安全性的全面回顾
Julien Guiraud,Wim van den Brink
Julien Guiraud
Alcohol dependence (AD) significantly impacts public health, affecting 3.4% of people aged 18-64 and contributing to around 12% of overall mortality. Individuals with AD have a markedly reduced life expectancy, dying up to 28 years earlier ...
Mesenchymal stem cells as a promising therapy for alcohol use disorder [0.03%]
间充质干细胞有望成为酒精使用障碍的治疗手段
Javiera Gallardo,Pablo Berríos-Cárcamo,Fernando Ezquer
Javiera Gallardo
Alcohol Use Disorder (AUD) is a highly prevalent medical condition characterized by impaired control over alcohol consumption, despite negative consequences on the individual's daily life and health. There is increasing evidence suggesting ...
Pharmacological activators of ALDH2: A new strategy for the treatment of alcohol use disorders [0.03%]
ALDH2的药理激活剂：治疗酒精使用障碍的新策略
Sofía Adasme-Reyes,Juan Fuentes,Ignacio Gutiérrez-Vega et al.
Sofía Adasme-Reyes et al.
In mammals, ethanol is metabolized to acetaldehyde mainly by the liver alcohol dehydrogenase (ADH), and acetaldehyde is subsequently oxidized to acetate by mitochondrial aldehyde dehydrogenase (ALDH2). The presence of an inactive variant of...
Introduction: Approved treatments for alcohol use disorder by regulatory agencies [0.03%]
前言：监管机构批准的酒精使用障碍治疗措施
Rosana Camarini,Fábio Cardoso Cruz
Rosana Camarini
Alcohol, the most widely consumed substance globally, can lead to severe adverse effects for both users and those around them. Chronic ethanol consumption may lead to alcohol use disorder (AUD), a chronic relapsing condition characterized b...
Rúbia Maria Weffort de Oliveira,Nathalia Akemi Kohara,Humberto Milani
Rúbia Maria Weffort de Oliveira
The absence of blood flow in cerebral ischemic conditions triggers a multitude of intricate pathophysiological mechanisms, including excitotoxicity, oxidative stress, neuroinflammation, disruption of the blood-brain barrier and white matter...