NK92 cells stably transfected with CD16 are efficient against multiple myeloma cells ex vivo and in vivo, especially if combined with daratumumab [0.03%]
稳定的CD16基因转染的NK92细胞能够有效治疗多发性骨髓瘤，特别是与达雷木单抗联合使用时更是如此
David Giraldos,Evelyn Galano-Frutos,Laura Cambronero-Arregui et al.
David Giraldos et al.
Adoptive cell therapy and the use of monoclonal antibodies are two therapeutic modalities implemented in the treatment of multiple myeloma (MM). In this study, we combined the anti-CD38 therapeutic mAb daratumumab with different types of NK...
A versatile silica nanoparticle platform for induction of T cell responses - applied for therapeutic vaccination against HPV16 E6/E7-positive tumors in MHC-humanized mice [0.03%]
一种灵活的硅纳米粒子平台可诱发T细胞反应并用于MHC人源化小鼠中针对HPV16E6 / E7阳性肿瘤的治疗性疫苗接种应用于
Sebastian Kruse,Lia T Fricke,Samantha Zottnick et al.
Sebastian Kruse et al.
Therapeutic vaccines represent a promising treatment option for (pre)cancerous lesions, such as human papillomavirus-induced malignancies. They act via administration of tumor-specific antigens, leading to induction of antigen-specific cyto...
Anti-FAP CAR-NK cells as a novel targeted therapy against cervical cancer and cancer-associated fibroblasts [0.03%]
针对宫颈癌和癌症相关成纤维细胞的抗FAP CAR-NK细胞作为新型靶向治疗方案
Robert Polten,Ivana Kutle,Jan Lennart Stalp et al.
Robert Polten et al.
The tumor microenvironment (TME) has a central role in many cancers, particularly by fostering an immunosuppressive milieu. Chimeric antigen receptor (CAR)-based immunotherapy displays a promising strategy to re-direct immune cells toward s...
Divergent on-target off-tumor effects by CAR T and CAR NK cells suggest different efficacy and safety of cell therapies [0.03%]
脱靶效应的不同表明CAR-T细胞和CAR-NK细胞疗法的安全性和有效性不同
Katharina Schindler-Wnek,Anika Stahringer,Nadine Heimer et al.
Katharina Schindler-Wnek et al.
CAR-based cell therapies have shown clinical success in treating various cancers, with CAR T cell therapies entering the clinical route and CAR NK cell therapies being evaluated in early-stage clinical trials. A key challenge is the presenc...
Chronic antigen stimulation in melanoma induces T cell exhaustion and limits efficacy of T cell bispecific therapies [0.03%]
慢性抗原刺激会诱导黑色素瘤中的T细胞耗竭并限制双特异性T细胞治疗的疗效
Idil Hutter-Karakoc,Eleni Maria Varypataki,Aparna Neelakandhan et al.
Idil Hutter-Karakoc et al.
T cell bispecific antibodies (TCBs) have demonstrated promising results in patients with solid tumors, yet the immunological mechanisms influencing their efficacy require further investigation. T cell exhaustion, induced by prolonged antige...
A dual compartment peripheral blood signature of soluble and membrane-bound immune checkpoints predicts outcome in lymphoma patients [0.03%]
溶血免疫检查点的双重周边血液标志物可预测淋巴瘤患者的治疗结果
Joao Gorgulho,Timo Trenkner,Eva Kinkel et al.
Joao Gorgulho et al.
Lymphomas, particularly aggressive non-Hodgkin lymphomas (NHL), remain challenging due to poor outcomes in a subset of patients who fail initial therapy. Current minimally invasive biomarkers for risk stratification need further improvement...
Differential distribution of immune checkpoints across molecular subtypes of colorectal cancer [0.03%]
免疫检查点在不同分子分型的结直肠癌中差异分布
Sofia Edin,Björn Gylling,Xingru Li et al.
Sofia Edin et al.
The recent introduction of immune checkpoint inhibitor therapy has significantly improved outcomes for patients with colorectal cancer (CRC). The most pronounced clinical benefits were observed in patients with immunogenic microsatellite in...
CAR-T cell engineered with TCR-like antibody specific for HBV surface antigen epitope E183-91/HLA-A *0201 exhibit potent activity against HBV-HCC [0.03%]
特异性识别乙肝病毒表面抗原表位E183-91/HLA-A*0201的TCR样抗体工程CAR-T细胞对HBV相关肝癌具有良好的杀伤作用
Fengling Wang,Jiaqian Li,Yong Huang et al.
Fengling Wang et al.
CAR-T cell therapy demonstrates significant efficacy in hematologic malignancies, with target selection critically determining therapeutic outcomes. However, the available tumor surface antigens are limited, especially in the treatment of s...
CyTOF profiling of bone marrow immune dynamics across myeloma stages [0.03%]
用于多发性骨髓瘤各阶段骨髓免疫细胞动态分析的CyTOF技术
Dana Cholujova,Gabor Beke,Lubos Klucar et al.
Dana Cholujova et al.
Multiple myeloma (MM) orchestrates a profound disruption of immune balance within the bone marrow (BM) microenvironment, driving disease progression and therapeutic resistance. To better understand these complex immune dynamics, we used hig...
Low triglyceride levels are associated with increased risk of immune-related adverse events in patients receiving immune checkpoint inhibitors [0.03%]
低甘油三酯水平与接受免疫检查点抑制剂治疗患者的免疫相关不良事件风险增加有关
Nora Möhn,Emily Narten,Laura Duzzi et al.
Nora Möhn et al.
Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy by enhancing anti-tumor immune responses, yet their use can lead to immune-related adverse events (irAE), including neurological complications. Despite their clinical rel...