Contrasting functions of CD73 and adenosine in CD8+ T-cell exhaustion during antitumor immunity [0.03%]
CD8⁺T细胞在抗肿瘤免疫过程中CD73和腺苷的功能作用对比研究
Juan Saavedra-Almarza,Solange Gouët,Felipe Malgue et al.
Juan Saavedra-Almarza et al.
T-cell exhaustion is a state of functional decline in T cells, driven by chronic antigen exposure and inhibitory signals within the tumor microenvironment. Exhausted CD8+ T cells (Tex) derive from precursor exhausted T cells (Tpex), a self-...
Polarization of tumor-infiltrating macrophages predicts complete response to neoadjuvant treatment in patients with rectal cancer [0.03%]
肿瘤浸润巨噬细胞的极化可预测直肠癌新辅助治疗完全反应患者的预后
Aylin Alkan,Fabian Byvald,Rode Grönkvist et al.
Aylin Alkan et al.
Characterizing the composition of immune cells in the tumor microenvironment (TME) has shown promise in understanding variable responses to neoadjuvant treatment in rectal cancer. Despite this, no method has been established that can confid...
Prednisolone modulates CD8⁺ and regulatory T-cell activity to dampen response to immune checkpoint inhibitor therapy in melanoma [0.03%]
prednisolone通过调节CD8⁺和调节性T细胞活性来抑制免疫检查点抑制剂治疗黑色素瘤的应答
Jesse R Brown,Bernadette Pedersen,Georgina V Long et al.
Jesse R Brown et al.
Immune checkpoint inhibitors (ICIs) have transformed the treatment of advanced melanoma, yet their efficacy is limited by high-grade immune-related adverse events that often require treatment with systemic corticosteroids. Although corticos...
KRAS-elicited PDIA6 blocks PERK-dependent immunogenic cell death in pancreatic carcinoma [0.03%]
KRAS激活的PDIA6通过抑制胰腺癌中的PERK依赖性免疫原性细胞死亡来促进肿瘤生长
Liwei Zhao,Peng Liu,Guido Kroemer et al.
Liwei Zhao et al.
KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) remains largely refractory to immune checkpoint blockade. Wang et al. identified PDIA6 as a KRAS-driven suppressor of PERK-dependent immunogenic cell death, fostering immune exclusion. PDI...
B cells and humoral immunity in melanoma: regulatory and autoimmune-like features and implications for immunotherapy [0.03%]
黑色素瘤中的B细胞和体液免疫：调控及自身免疫样特征及其对免疫治疗的意义
Lucy Booth,Madeena Mahmood,Xinyi Chen et al.
Lucy Booth et al.
B cells and the humoral immune response are increasingly recognized as critical modulators of melanoma progression and immunotherapy outcomes. While checkpoint inhibitor (CPI) therapy was developed to target T cell exhaustion mechanisms, em...
PD-1 genetic fate mapping uncovers immune cell diversity mediating the efficacy of combined PD-1 blockade and chemotherapy [0.03%]
PD-1基因谱系示踪发现免疫细胞多样性可介导联合化疗和PD-1阻断的疗效
Ayuko Yamaguchi,Haruka Suzuki,Shunsuke Takasuga et al.
Ayuko Yamaguchi et al.
Combined cytotoxic chemotherapy and immune checkpoint inhibition (ICI) improves outcomes in PD-L1-low lung cancer, but transient and broad PD-1 expression across immune cells complicates the understanding of the underlying mechanisms. We ge...
Steroid receptor coactivator 3-deficient regulatory T cells eradicate multiple solid tumors in syngeneic mouse models [0.03%]
雄性小鼠模型中缺乏类固醇受体协同激活因子3的调节T细胞能够根除多种实体肿瘤
Nuri Sung,Eunsu Kim,Yosef Gilad et al.
Nuri Sung et al.
Steroid receptor coactivator 3 (SRC-3) is highly expressed in regulatory T cells (Tregs) and is important for their immunosuppressive activity. Recently, we demonstrated that disrupting SRC-3 expression in Tregs eliminates triple-negative b...
Multidimensional immune profiling uncovers biphasic peripheral T-cell dynamics after chemoradiation in patients with locally advanced head and neck cancer [0.03%]
多维度免疫谱分析揭示局部晚期头颈部癌症患者放化疗后的外周T细胞双相动力学特征
Benoît Lecoester,Yaoyao Xie,Xushan Sun et al.
Benoît Lecoester et al.
Cisplatin-based concurrent chemoradiation (CRT) remains the standard treatment for locally advanced head and neck squamous cell carcinoma (LA-HNSCC), yet recurrence rates remain high. Attempts to combine immune checkpoint inhibitors with CR...
TNF-α deficiency underlies NK cell dysfunction in colorectal cancer [0.03%]
肿瘤坏死因子TNF-α缺乏导致结直肠癌中NK细胞功能障碍
Silvia Ruggeri,Beatrice Pizzitola,Mattia Laffranchi et al.
Silvia Ruggeri et al.
Natural killer (NK) cells are central to innate antitumor immunity, yet their function is systemically compromised in colorectal cancer (CRC). We show that CRC patients exhibit early and pronounced alterations in peripheral blood NK cells, ...
A mixed inflammatory peripheral signature defines clinical outcomes in a phase II trial combining pembrolizumab with paclitaxel and carboplatin in melanoma [0.03%]
帕博利珠单抗联合紫杉醇和卡铂治疗黑色素瘤II期试验中混杂的炎性外围特征决定临床结局
Caroline Lambert,Rahima Jamal,Paméla Thébault et al.
Caroline Lambert et al.
Checkpoint blockade of PD-1 with pembrolizumab provides long-term survival to a significant proportion of patients with metastatic melanoma. Pembrolizumab has been successfully used in combination with chemotherapy in non-small-cell lung ca...
Clinical Trial
Oncoimmunology. 2026 Dec 31;15(1):2631244. DOI:10.1080/2162402X.2026.2631244 2026