Dectin-1 signaling promotes Galectin-3 shedding and expansion of immunosuppressive CD71+ erythroid cells in breast cancer [0.03%]
Dectin-1信号转导促进半乳糖凝集素-3脱落和免疫抑制性CD71+红系细胞在乳腺癌中的增殖
Ako Azimi,Amirhossein Rahmati,Shima Shahbaz et al.
Ako Azimi et al.
Immunotherapy with immune checkpoint inhibitors (ICIs) has transformed cancer treatment, yet many patients fail to respond, underscoring the need to better understand mechanisms of resistance. One emerging mechanism involves the recruitment...
Umbilical cord blood natural killer cells improve anti-GD2 antibody efficacy in neuroblastoma: from mouse to human [0.03%]
脐带血自然杀伤细胞能提高抗GD2单克隆抗体在神经母细胞瘤中疗效：从小鼠到人类
Mengjia Song,Yingxia Lan,Xiya Tan et al.
Mengjia Song et al.
Despite advances in anti-disialoganglioside (GD2) immunotherapy, high-risk neuroblastoma (NB) remains a clinical challenge. Natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity is a potent mechanism of action of anti-G...
An orthotopic organoid-based model to study early CD8⁺ T cell dysfunction and immunotherapy response in colorectal cancer [0.03%]
一种正确定位的类器官模型：研究结直肠癌早期CD8⁺T细胞功能障碍和免疫治疗反应
Lorenzo Lucantonio,Ludovica Schiano,Francesca Sozio et al.
Lorenzo Lucantonio et al.
Colorectal cancer (CRC) treatment represents a major clinical challenge, with immunotherapy providing durable responses only in a minority of patients. A deeper understanding of CD8⁺ T cell exhaustion and its contribution to immune checkpo...
Reshaping immunotherapy sequencing strategy: equivalent survival with induction plus consolidation vs. consolidation-only strategy in unresectable stage III NSCLC [0.03%]
重塑免疫治疗顺序策略：诱导联合巩固与单纯巩固方案在不可切除III期NSCLC中生存结局相当
Wenlu Chen,Anqi Zhao,Yu Liang et al.
Wenlu Chen et al.
Objective: To compare the efficacy and safety of a sequential combination of chemoradiotherapy (CRT) with immune checkpoint inhibitors (ICIs) administered as induction plus consolidation versus consolidation-only in patie...
Multicenter Study
Oncoimmunology. 2026 Dec 31;15(1):2670221. DOI:10.1080/2162402X.2026.2670221 2026
Novel multiplex immunofluorescence-based tumor inflammation score provides apparent predictive biomarker in a phase I/II study of pembrolizumab with gemcitabine in patients with previously-treated advanced non-small cell lung cancer (NSCLC) [0.03%]
新型多重免疫荧光基肿瘤炎症评分在帕博利珠单抗联合吉西他滨治疗经治晚期非小细胞肺癌（NSCLC）患者I/II期研究中提供显著的预测生物标志物作用
Rachel E Sanborn,Shawn M Jensen,Christopher Paustian et al.
Rachel E Sanborn et al.
Retrospective characterization of cell‒cell relationships in the tumor microenvironment provides significantly better predictive power than PD-L1 expression, tumor mutational burden (TMB), or gene expression profiles. In this small study a...
Clinical Trial
Oncoimmunology. 2026 Dec 31;15(1):2661444. DOI:10.1080/2162402X.2026.2661444 2026
Deep learning based on CD3 histological slides for prediction of colon cancer outcome: analysis of three international stage III colon cancer cohorts [0.03%]
基于CD3组织切片的深度学习预测结肠癌预后：国际三期结肠癌队列分析
Julie Lécuelle,Caroline Truntzer,Debora Basile et al.
Julie Lécuelle et al.
Prognostic stratification in stage III colon cancer remains poor, despite treatment advances. Tumor-infiltrating lymphocytes, particularly CD3+ T cells, are potential prognostic markers, but manual assessment is labor-intensive and not robu...
Sex-based considerations in the choice for a TLR9 or TLR7/8 agonist to arm the sentinel lymph node in early-stage melanoma [0.03%]
早期黑色素瘤中基于性别选择TLR9或TLR7/8激动剂以武装滤泡淋巴结的考虑因素
Jessica C L Notohardjo,Elisa C Toffoli,Tara Muijlwijk et al.
Jessica C L Notohardjo et al.
Intradermal delivery of the Toll-like receptor (TLR)-9 agonist agatolimod/CPG7909, prior to sentinel lymph node (SLN) biopsy was previously shown to induce locoregional and systemic immunity, reduce tumor-involved SLN rates, and improve rec...
Flora Doffe,Xiaolian Deng,Zhe Shen et al.
Flora Doffe et al.
Antibody-drug conjugates (ADCs) combine the target specificity of monoclonal antibodies with the cytotoxic potency of small-molecule payloads. In recent years ADCs have emerged as a clinically validated component of modern precision oncolog...
Pleiotropic effects of BET inhibition broadly boost tumor immunogenicity to CD8+ T cells [0.03%]
BET抑制的多效性可广泛增强肿瘤的免疫原性以促进CD8+t细胞作用
Jeroen Melief,Lucas Baldran-Groves,Marc-Antoine Gerault et al.
Jeroen Melief et al.
BET inhibitors (BETi) have shown potential to augment tumor immunogenicity in melanoma. However, conflicting evidence exists regarding their precise mechanism of action, and their overall impact on melanoma immunogenicity and antitumoral T ...
Transglutaminase 2 regulates innate immunity: mechanisms and therapeutic implications [0.03%]
转谷氨酰胺酶2调节先天性免疫：机制及治疗意义
Manuela D&#x;Eletto,Luca Occhigrossi,Fiorella Colasuonno et al.
Manuela D&#x;Eletto et al.
Innate immunity constitutes the primary barrier against invading pathogens and plays a crucial role in coordinating the initiation and modulation of adaptive immune responses. Transglutaminase 2 (TG2), a ubiquitously expressed multifunction...