Combined tumor-associated microbiome and immune gene expression profiling predict response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer [0.03%]
肿瘤相关微生物组和免疫基因表达联合分析可预测局部晚期直肠癌对新辅助化放疗的疗效
Raffaello Roesel,Francesco Strati,Camilla Basso et al.
Raffaello Roesel et al.
Locally advanced rectal cancer (LARC) is treated with neoadjuvant chemo-radiotherapy (nCRT) followed by surgery. A minority of patients show complete response (CR) to nCRT and may avoid surgery and its functional consequences. Instead, most...
Molecular and immunological features associated with long-term benefits in metastatic NSCLC patients undergoing immune checkpoint blockade [0.03%]
接受免疫检查点封锁治疗的转移性非小细胞肺癌患者长期获益相关的分子和免疫学特征
Pedro Rocha,Rafael Bach,Laura Masfarré et al.
Pedro Rocha et al.
Introduction: Immunotherapy is firmly established as a treatment regimen in various solid tumors, driven by its exceptional benefits in a selected group of patients. Despite widespread adoption of immune checkpoint blocka...
Evaluating the effect of immune checkpoint inhibitor treatment on chronic obstructive pulmonary disease in lung cancer patients [0.03%]
评估免疫检查点抑制剂治疗对肺癌患者慢性阻塞性肺疾病的影响
Anet Greib,Songzhu Zhao,Michelle Ploch et al.
Anet Greib et al.
Immune checkpoint inhibitors (ICIs) are first line treatment for advanced lung cancer. Tobacco use is a shared risk factor for lung cancer and chronic obstructive pulmonary disease (COPD). Although many patients with COPD and lung cancer re...
Patient-specific HLA-I subtypes predict response to immune checkpoint blockade [0.03%]
特定患者的HLA-I亚型可预测其对免疫检查点阻断的反应
Kyrillus S Shohdy,Jack Atherton,Jessica Longland et al.
Kyrillus S Shohdy et al.
Specific shared HLA-I alleles were linked to the response to immune checkpoint blockade (ICB). We aimed to identify the HLA-A subtypes associated with maximum benefit from ICB. We compiled a clinical dataset of patients who underwent a CLIA...
Dual nanobody-redirected and Bi-specific CD13/TIM3 CAR T cells eliminate AML xenografts without toxicity to human HSCs [0.03%]
双重纳米抗体重定向和双特异性CD13/TIM3 CAR T细胞消除AML异种移植物而不对人体HSC产生毒性
Xuyao Zhang,Zijie Feng,Annapurna Pranatharthi Haran et al.
Xuyao Zhang et al.
Adoptive cell therapy including chimeric antigen receptor (CAR) T cells targeting CD19 has been approved by FDA to treat B cell-derived malignancies with remarkable success. The success has not yet been expanded to treating Acute Myeloid Le...
Spatial characterization of tertiary lymphoid structures as predictive biomarkers for immune checkpoint blockade in head and neck squamous cell carcinoma [0.03%]
三级淋巴样结构的空间特征作为头颈部鳞状细胞癌免疫检查点阻断的预测生物标志物
Daniel A Ruiz-Torres,Michael E Bryan,Shun Hirayama et al.
Daniel A Ruiz-Torres et al.
Immune checkpoint blockade (ICB) is the standard of care for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC), yet efficacy remains low. The combined positive score (CPS) for PD-L1 is the only biomarker approved to predict...
Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses [0.03%]
患者衍生的肿瘤移植物模型揭示了肿瘤免疫微环境中不同的可重复免疫治疗反应
Rita Turpin,Karita Peltonen,Jenna H Rannikko et al.
Rita Turpin et al.
Tumor-resident immune cells play a crucial role in eliciting anti-tumor immunity and immunomodulatory drug responses, yet these functions have been difficult to study without tractable models of the tumor immune microenvironment (TIME). Pat...
IL-15 transpresentation by ovarian cancer cells improves CD34+ progenitor-derived NK cell's anti-tumor functionality [0.03%]
卵巢癌细胞的IL-15转呈现可改善CD34+祖细胞衍生的NK细胞的抗肿瘤功能
M Vidal-Manrique,T Nieuwenstein,L Hooijmaijers et al.
M Vidal-Manrique et al.
Ovarian cancer (OC) is the most lethal gynecological malignancy. As high numbers of Natural Killer (NK) cells in ascites associate with improved survival, the adoptive transfer of allogeneic NK cells is an attractive therapeutic strategy. A...
The pancreatic tumor microenvironment of treatment-naïve patients causes a functional shift in γδ T cells, impairing their anti-tumoral defense [0.03%]
胰腺肿瘤微环境导致初治患者的γδT细胞功能转变，削弱其抗肿瘤防御能力
Elena Lo Presti,Francesca Cupaioli,Daniela Scimeca et al.
Elena Lo Presti et al.
Pancreatic ductal adenocarcinoma (PDAC) presents a unique challenge for researchers due to its late diagnosis caused by vague symptoms and lack of early detection markers. Additionally, PDAC is characterized by an immunosuppressive microenv...
Metabolic heterogeneity in tumor cells impacts immunology in lung squamous cell carcinoma [0.03%]
肿瘤细胞的代谢异质性影响肺鳞状细胞癌的免疫学特性
Qian Wang,Na Sun,Chaoyang Zhang et al.
Qian Wang et al.
Metabolic processes are crucial in immune regulation, yet the impact of metabolic heterogeneity on immunological functions remains unclear. Integrating metabolomics into immunology allows the exploration of the interactions of multilayered ...