Sabrina Forveille,Liwei Zhao,Allan Sauvat et al.
Sabrina Forveille et al.
Antibody-drug conjugates (ADCs) enable targeted delivery of cytotoxic payload to cancer cells. Here, we characterized the mode of action of the ADC patritumab deruxtecan, which is a monoclonal antibody specific for Erb-B2 Receptor Tyrosine ...
The combination of body mass index and serum creatinine levels predicts survival in patients with Hodgkin lymphoma treated with nivolumab in the CheckMate 205 study [0.03%]
体重指数和血清肌酐水平的联合预测CheckMate 205研究中纳武利尤单抗治疗霍奇金淋巴瘤患者生存情况
Rosaria De Filippi,Fortunato Morabito,Giovanni Tripepi et al.
Rosaria De Filippi et al.
Patients with solid tumors and a higher body mass index (BMI) experience improved survival after receiving anti-PD1 antibodies. The predictive role of BMI in Hodgkin Lymphoma (HL), the most sensitive malignancy to PD1-blockade, remains uncl...
Cross-disease integration of single-cell RNA sequencing data from lung myeloid cells reveals TAM signature in in vitro model [0.03%]
来自肺髓样细胞的单细胞RNA测序数据的跨疾病整合揭示了体外模型中的TAM信号
Catarina Pinto,Jakub Widawski,Sophie Zahalka et al.
Catarina Pinto et al.
Advancements in single-cell RNA sequencing (scRNA-seq) have revealed the phenotypic and functional diversity of tumor-associated macrophages (TAMs), identifying specific populations that directly impact the antitumor response. However, desp...
Co-targeting of VEGFR2 and PD-L1 promotes survival and vasculature normalization in pleural mesothelioma [0.03%]
vegfr2和pd-l1协同靶向促进胸膜间皮瘤的存活和血管正常化
Sophie Rovers,Jonas Van Audenaerde,Ruben Verloy et al.
Sophie Rovers et al.
Pleural mesothelioma (PM) is an aggressive cancer caused by asbestos exposure, with limited treatment options and poor prognosis, highlighting the need for more effective therapies. Combining immune checkpoint blockade with anti-angiogenic ...
Mitochondrial DNA transfer between malignant cells and T lymphocytes shapes the cancer-immunity dialogue [0.03%]
线粒体DNA在恶性细胞和T淋巴细胞之间的转移塑造了癌免疫互作对话
Liwei Zhao,Peng Liu,Oliver Kepp et al.
Liwei Zhao et al.
Nonmutated mitochondrial DNA (mtDNA) from T lymphocytes can be incorporated into cancer cells bearing mutated mtDNA to repair their bioenergetic deficiency. However, a recent paper by Ikeda et al. indicates that mutated mtDNA from malignant...
Increasing the odds: antibody-mediated delivery of two distinct immunogenic T-cell epitopes with one antibody [0.03%]
抗体介导的两种不同的T细胞表位免疫原性的增加
Willemijn van der Wulp,Dennis F G Remst,Carli S Koster et al.
Willemijn van der Wulp et al.
Antibody-epitope conjugates (AECs) proved to be a promising new therapeutic strategy to redirect virus-specific CD8+ T cells toward cancer cells by delivering T-cell epitopes. To be able to redirect a larger fraction of the virus-specific T...
Routing immunomodulatory cytokine-encoded mRNAs to the omentum: turning an enemy into an ally in peritoneal metastasis [0.03%]
将编码免疫调节细胞因子的mRNA递送至大网膜：在腹膜转移中化敌为友
Leire Arrizabalaga,Ignacio Melero,Pedro Berraondo et al.
Leire Arrizabalaga et al.
Peritoneal metastases remain a significant clinical challenge owing to the immunosuppressive nature of the omentum, which serves as a protective niche for disseminated tumor cells. Our recent study explored the targeted delivery of immunomo...
Updates on radiotherapy-immunotherapy combinations: Proceedings of 8th Annual ImmunoRad Conference [0.03%]
放射治疗与免疫治疗联合的最新进展——第八届ImmunoRad大会报告
Fereshteh Talebi,Fabiana Gregucci,Jalal Ahmed et al.
Fereshteh Talebi et al.
The annual ImmunoRad Conference has established itself as a recurrent occasion to explore the possibility of combining radiation therapy (RT) and immunotherapy (IT) for clinical cancer management. Bringing together a number of preclinical a...
Loss of the extracellular protease ADAMTS1 reveals an antitumorigenic program involving the action of NIDOGEN-1 on macrophage polarization [0.03%]
基质蛋白酶ADAMTS1缺失通过分泌因子NIDogens调控巨噬细胞极化来抑制肿瘤生长
Rita Caracuel-Peramos,Francisco Javier Rodríguez-Baena,Silvia Redondo-García et al.
Rita Caracuel-Peramos et al.
Recent research highlighted the contribution of extracellular matrix, and particularly of ADAMTS proteases, in immune regulation. Now, our work with melanoma and mammary tumor models revealed that tumor blockade induced by the lack of Adamt...
Partial mitochondrial involvement in the antiproliferative and immunostimulatory effects of PT-112 [0.03%]
PT-112的抗增殖和免疫刺激作用部分通过线粒体途径实现
Ruth Soler-Agesta,Manuel Beltrán-Visiedo,Ai Sato et al.
Ruth Soler-Agesta et al.
PT-112 is a novel small molecule exhibiting promising clinical activity in patients with solid tumors. PT-112 kills malignant cells by inhibiting ribosome biogenesis while promoting the emission of immunostimulatory signals. Accordingly, PT...