Immunogenic cell death and bystander killing: expanding the therapeutic potential of modern antibody-drug conjugates [0.03%]
抗体药物偶联物治疗潜力的扩展：免疫性细胞死亡与旁观者杀伤的作用
Oliver Kepp,Guido Kroemer
Oliver Kepp
HER3-DXd and T-DXd are antibody-drug conjugates (ADCs) that induce immunogenic cell death and bystander killing, enhancing antitumor immunity beyond target-specific cytotoxicity. These findings highlight novel mechanisms that can overcome a...
ProS1-MerTK signaling in CD4 T cells: implications for TIL expansion and functionality [0.03%]
CD4 T 细胞中的 ProS1-MerTK 信号传导：对TIL扩增和功能的影响
Annina Kurzay,Sara Fresnillo Saló,Anne Rahbech et al.
Annina Kurzay et al.
Cancer immunotherapy predominantly targets CD8 T cells, but recent evidence highlights the importance of CD4 T cells in adoptive cell therapy (ACT). The TAM receptor MerTK regulates immune responses and has been shown to provide costimulato...
TIGIT blockade in the context of BCMA-CART cell therapy does not augment efficacy in a multiple myeloma mouse model [0.03%]
在多发性骨髓瘤小鼠模型中，TIGIT阻断不会增强BCMA-CART细胞治疗的效果
Aina Oliver-Caldes,Joan Mañe Pujol,Anthony M Battram et al.
Aina Oliver-Caldes et al.
BCMA-directed CAR-T therapies have shown promising results in multiple myeloma (MM). However, patients continue to relapse. T cell exhaustion with increased TIGIT expression is a resistance mechanism which was confirmed in CAR-T cells from ...
Liwei Zhao,Peng Liu,Oliver Kepp et al.
Liwei Zhao et al.
Recent findings reveal that macrophages actively control clearance by desialylating target cells via NEU1 and releasing cathepsin-cleaved calreticulin (CALR) to mark them for phagocytosis. This uncovers a dual role for CALR as immune activa...
Disruption of cholesterol homeostasis by antidepressants induces immunogenic cell death [0.03%]
抗抑郁药干扰胆固醇稳态诱导免疫原性细胞死亡
Karla Alvarez-Valadez,Jonathan G Pol,Guido Kroemer et al.
Karla Alvarez-Valadez et al.
Sertraline and indatraline are two antidepressants that function as serotonin reuptake inhibitors and have demonstrated promising anticancer potential, although their precise mechanisms of action remain unclear. Both compounds trigger chole...
An SNP-dependent cancer-testis antigenic epitope serves as a promising immunotherapeutic target for cancer [0.03%]
一个依赖于SNP的癌症-睾丸抗原表位作为癌症免疫治疗靶点的潜力研究
Kenji Murata,Tomoyuki Minowa,Tomohide Tsukahara et al.
Kenji Murata et al.
T cells recognize peptides presented by human leukocyte antigen molecules on the cell surface, enabling the immune surveillance of pathological conditions such as cancer. Cancer-testis (CT) antigens are promising targets for cancer immunoth...
Chemoimmunomodulation in triple negative breast cancer: a key to maximizing anti-PD-1 chemoimmunotherapeutic efficacy [0.03%]
三阴性乳腺癌的化疗免疫调控：增强抗PD-1化疗免疫疗效的关键因素
Mohammed O Gbadamosi,Elizabeth Molchan,Mariana S Makarem et al.
Mohammed O Gbadamosi et al.
Triple-negative breast cancer (TNBC) is among the aggressive subtype of breast cancer with a distinct lack of viable treatment strategies and poor clinical outcomes. Anti-PD-1 chemoimmunotherapy (CIT), which leverages the vast array of immu...
Mature tertiary lymphoid structures linked to HPV status and anti-PD-1 based chemoimmunotherapy response in head and neck squamous cell carcinoma [0.03%]
与HPV状态及抗PD-1为基础的化疗免疫治疗反应相关的成熟的三级淋巴组织在头颈鳞状细胞癌中的作用
Lizao Zhang,Siqi Ren,Tianjun Lan et al.
Lizao Zhang et al.
Mature tertiary lymphoid structures (TLSs) are immune aggregates associated with immune checkpoint blockade (ICB) responses in various cancers, yet their role in chemoimmunotherapy response in head and neck squamous cell carcinoma (HNSCC) r...
Benzodiazepines interfere with the efficacy of pembrolizumab-based cancer immunotherapy. Results of a nationwide cohort study including over 50,000 participants with advanced lung cancer [0.03%]
苯二氮卓类药物干扰派姆单抗为基础的癌症免疫治疗的效果。一项包含五万多例晚期肺癌患者的全国队列研究结果
Léa Montégut,Adrien Rousseau,Cinzia Ungolo et al.
Léa Montégut et al.
We previously reported that elevated levels of diazepam binding inhibitor (DBI), also called 'endozepine' because it acts as an endogenous benzodiazepine equivalent on the gamma-aminobutyric acid type A receptor, constitutes a potential ris...
Uncovering common transcriptional features shared by mature peripheral blood PMN-MDSCs and tumor-infiltrating neutrophils in humans [0.03%]
揭示人外周血成熟PMN-MDSC和肿瘤浸润中性粒细胞共有的转录特征
Chiara Lattanzi,Francisco Bianchetto-Aguilera,Marta Donini et al.
Chiara Lattanzi et al.
Human polymorphonuclear-myeloid-derived suppressor cells (PMN-MDSCs) consist of circulating low-density neutrophils (LDNs) characterized by the ability to inhibit T-cell responses. In previous studies, we demonstrated that the mature fracti...