Follistatin like-1 (Fstl1) regulates adipose tissue development in zebrafish [0.03%]
类成纤维细胞生长因子蛋白Fstl1调控斑马鱼脂肪组织发育
Lucía Guggeri,Ileana Sosa-Redaelli,Magdalena Cárdenas-Rodríguez et al.
Lucía Guggeri et al.
Obesity is a highly prevalent disorder with complex aetiology. Therefore, studying its associated cellular and molecular pathways may be aided by analysing genetic tractable diseases. In this context, the study of ciliopathies such as Barde...
Defining the role of 2,2',4,4'-tetrabromodiphenyl ether in 3T3-L1 cellular differentiation by transcriptome sequencing analysis [0.03%]
利用转录组测序分析定义2,2',4,4'-四溴对二苯醚在3T3-L1细胞分化中的作用
Zao-Ling Liu,Aerna Qiayimaerdan,Yong Fan et al.
Zao-Ling Liu et al.
This study aims to investigates the effect of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) on the differentiation of 3T3-L1 cells and its mechanism of action. These 3T3-L1 cells were induced to differentiate in vitro using methylisobutylxant...
The early transition to cold-induced browning in mouse subcutaneous white adipose tissue (scWAT) involves proteins related to nerve remodeling, cytoskeleton, mitochondria, and immune cells [0.03%]
小鼠皮下白色脂肪组织冷诱导棕色化早期过渡涉及神经重塑、细胞骨架、线粒体和免疫细胞相关蛋白
Magdalena Blaszkiewicz,Cory P Johnson,Jake W Willows et al.
Magdalena Blaszkiewicz et al.
White adipose tissue (WAT) is a dynamic organ capable of remodelling in response to metabolic state. For example, in response to stimuli such as cold exposure, WAT can develop inducible brown adipocytes ('browning') capable of non-shivering...
Identification of hub genes in the crosstalk between type 2 diabetic nephropathy and obesity according to bioinformatics analysis [0.03%]
生物信息学分析确定2型糖尿病肾病与肥胖互作的枢纽基因
Shaomin Shi,Ke Ding,Feng Chen et al.
Shaomin Shi et al.
Diabetic nephropathy (DN) and obesity bring a huge burden to society. Obesity plays a crucial role in the progression of type 2 DN, but the pathophysiology remains unclear. Thus, we aimed the explore the association between type 2 DN and ob...
A key role for P2RX5 in brown adipocyte differentiation and energy homeostasis [0.03%]
P2RX5在棕色脂肪细胞分化和能量稳态中发挥关键作用
Maria Razzoli,Seth McGonigle,Bhavani Shankar Sahu et al.
Maria Razzoli et al.
Brown adipocytes are defined based on a distinct morphology and genetic signature that includes, amongst others, the expression of the Purinergic 2 Receptor X5 (P2RX5). However, the role of P2RX5 in brown adipocyte and brown adipose tissue ...
Lipid accumulation in adipose tissue-resident iNKT cells contributes to an inflammatory phenotype [0.03%]
脂肪组织驻留的iNKT细胞中的脂质积累促成了其炎性表型
Imogen Morris,Frank Vrieling,Annemieke Bouwman et al.
Imogen Morris et al.
Reciprocal communication between adipocytes and immune cells is essential to maintain optimal adipose tissue (AT) functionality. Amongst others, adipocytes directly interact with invariant NKT cells (iNKT cells), which in turn secrete vario...
An improved in vitro 3T3-L1 adipocyte model of inflammation and insulin resistance [0.03%]
一种改善了的体外3T3-L1脂肪细胞炎症和胰岛素抵抗模型
Ifeoluwa A Odeniyi,Bulbul Ahmed,Benjamin Anbiah et al.
Ifeoluwa A Odeniyi et al.
Tumor necrosis factor alpha (TNF-α)/hypoxia-treated 3T3-L1 adipocytes have been used to model inflamed and insulin-resistant adipose tissue: this study examines gaps in the model. We tested whether modulating TNF-α/hypoxia treatment time ...
10-Gingerol reduces cytoplasmic lipid droplets and induces lipolysis in 3T3-L1 adipocytes [0.03%]
姜辣素通过促进脂解减少3T3-L1细胞胞浆脂滴聚集
María Elizabeth Preciado-Ortiz,Erika Martínez-López,Trinidad García-Iglesias et al.
María Elizabeth Preciado-Ortiz et al.
Obesity is a globally prevalent metabolic disorder characterized by an increased number of adipose cells and excessive fat in adipocytes. Herbal medicines, such as ginger, have shown potential in treating obesity by inhibiting adipogenesis ...
Involvement of a battery of investigated genes in lipid droplet pathophysiology and associated comorbidities [0.03%]
一组候选基因通过脂滴介导与代谢性疾病发生发展密切相关
Sami N Al Harake,Yasamin Abedin,Fatema Hatoum et al.
Sami N Al Harake et al.
Lipid droplets (LDs) are highly specialized energy storage organelles involved in the maintenance of lipid homoeostasis by regulating lipid flux within white adipose tissue (WAT). The physiological function of adipocytes and LDs can be comp...
The change of epicardial adipose tissue characteristics and vulnerability for atrial fibrillation upon drastic weight loss [0.03%]
快速减重对心脏外膜脂肪组织特性及房颤易感性的影响
Eva R Meulendijks,Carolina Janssen-Telders,Elise L Hulsman et al.
Eva R Meulendijks et al.
Background: Obesity increases the risk of atrial fibrillation (AF). We hypothesize that 'obese' epicardial adipose tissue (EAT) is, regardless of comorbidities, associated with markers of AF vulnerability. ...